The Exquisite Machine

How science is opening up the mysteries of the heart, revealing the poetry in motion within the machine. Your heart is a miracle in motion, a marvel of construction unsurpassed by any human-made creation. It beats 100,000 times every day—if you were to live to 100, that would be more than 3 billion beats across your lifespan. Despite decades of effort in labs all over the world, we have not yet been able to replicate the heart’s perfect engineering. But, as Sian Harding shows us in The Exquisite Machine, new scientific developments are opening up the mysteries of the heart. And this explosion of new science—ultrafast imaging, gene editing, stem cells, artificial intelligence, and advanced sub-light microscopy—has crucial, real-world consequences for health and well-being. Harding—a world leader in cardiac research—explores the relation between the emotions and heart function, reporting that the heart not only responds to our emotions, it creates them as well. The condition known as Broken Heart Syndrome, for example, is a real disorder than can follow bereavement or stress. The Exquisite Machine describes the evolutionary forces that have shaped the heart’s response to damage, the astonishing rejuvenating power of stem cells, how we can avoid heart disease, and why it can be so hard to repair a damaged heart. It tells the stories of patients who have had the devastating experiences of a heart attack, chaotic heart rhythms, or stress-induced acute heart failure. And it describes how cutting-edge technologies are enabling experiments and clinical trials that will lead us to new solutions to the worldwide scourge of heart disease.

Originally published in 1997 by City Lights Books.

Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.

The bestselling author of Intern and Doctored tells the story of the thing that makes us tick For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was somehow the driver of emotion and the seat of the soul. As the cardiologist and bestselling author Sandeep Jauhar shows in Heart: A History, it was only recently that we demolished age-old taboos and devised the transformative procedures that have changed the way we live. Deftly alternating between key historical episodes and his own work, Jauhar tells the colorful and little-known story of the doctors who risked their careers and the patients who risked their lives to know and heal our most vital organ. He introduces us to Daniel Hale Williams, the African American doctor who performed the world’s first open heart surgery in Gilded Age Chicago. We meet C. Walton Lillehei, who connected a patient’s circulatory system to a healthy donor’s, paving the way for the heart-lung machine. And we encounter Wilson Greatbatch, who saved millions by inventing the pacemaker—by accident. Jauhar deftly braids these tales of discovery, hubris, and sorrow with moving accounts of his family’s history of heart ailments and the patients he’s treated over many years. He also confronts the limits of medical technology, arguing that future progress will depend more on how we choose to live than on the devices we invent. Affecting, engaging, and beautifully written, Heart: A History takes the full measure of the only organ that can move itself.

The best paper-flower artist working today, Livia Cetti, presents a comprehensive how-to manual for creating jaw-droppingly beautiful and unbelievably realistic blooms.

An orphan and thief, Hugo lives in the walls of a busy train station. He desperately believes a broken automaton will make his dreams come true. But when his world collides with an eccentric girl and a bitter old man, Hugo's undercover life are put in jeopardy. Turn the pages, follow the illustrations and enter an unforgettable new world!

The heart has consistently captured the human imagination. It has been singled out as a cultural icon, the repository of our deepest religious and artistic impulses, the organ whose steady functioning is understood, both literally and symbolically, as the very life force itself. The Sublime Engine will explore the profound sense of awe every person feels when they ponder the miracle encased within their ribs. In this lyrical history of our most essential organ, a critically-acclaimed novelist and a leading cardiologist--who happen to be brothers--draw upon history, science, religion, popular culture, and literature to illuminate all of the heart's physical and figurative chambers. Each of the four sections-- The Ancient Heart, The Renaissance Heart, The Modern Heart, and The Future Heart--will focus on a major epoch in our understanding of the heart and the hidden history of cardiology. Erudite, witty, and enthralling, The Sublime Engine makes the heart come alive for readers.

Andra wakes up from a cryogenic sleep 1,000 years later than she was supposed to, forcing her to team up with an exiled prince to navigate an unfamiliar planet in this smart, thrilling sci-fi adventure, perfect for fans of Renegades and Aurora Rising. When Andra wakes up, she's drowning. Not only that, but she's in a hot, dirty cave, it's the year 3102, and everyone keeps calling her Goddess. When Andra went into a cryonic sleep for a trip across the galaxy, she expected to wake up in a hundred years, not a thousand. Worst of all, the rest of the colonists--including her family and friends--are dead. They died centuries ago, and for some reason, their descendants think Andra's a deity. She knows she's nothing special, but she'll play along if it means she can figure out why she was left in stasis and how to get back to Earth. Zhade, the exiled bastard prince of Eerensed, has other plans. Four years ago, the sleeping Goddess's glass coffin disappeared from the palace, and Zhade devoted himself to finding it. Now he's hoping the Goddess will be the key to taking his rightful place on the throne--if he can get her to play her part, that is. Because if his people realize she doesn't actually have the power to save their dying planet, they'll kill her. With a vicious monarch on the throne and a city tearing apart at the seams, Zhade and Andra might never be able to unlock the mystery of her fate, let alone find a way to unseat the king, especially since Zhade hasn't exactly been forthcoming with Andra. And a thousand years from home, is there any way of knowing that Earth is better than the planet she's woken to?

Inspired by a brother's high school science project--a perpetual motion machine that could save the world-- The Perpetual Motion Machine is a memoir in essays that attempts to save a sibling by depicting the visceral pain that accompanies longing for some past impossibility. The collection has been a science project in its study of memory, in the calculation and plotting of the moments that make up a childhood. The preparation has been "in the field" in that it is built upon the gathering of lived experience; the evidence is photo albums, family interviews, and anecdotes from friends. The project has been one giant experiment--to see if they can all make it out alive.