Synthesis And Characterization Bioactive Conjugated Magnetic Iron Oxide Nanoparticles For Cancer Diagnostics And Therapy

Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine

Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

This handbook examines the recent advances in the nanotechnology of polymers and ceramics, which possess outstanding mechanical properties and compatibility given their unique physical and chemical properties caused by the unusually large surface area to volume ratios and high interfacial reactivity. This handbook highlights the various compositions and morphologies of polymer and ceramic nanomaterials that can serve as powerful tools for the diverse applications in areas such as electronics, photonics, shape-memory alloys, biomaterials and biomedical nanomaterials, graphene-based technologies, and textiles and packaging. The handbook addresses safety, economics, green production and sustainability. The book contains a section on functionalization of these molecules, which only increases the possibility of developing even more versatile materials that can be fine-tuned for specific applications. Filling a gap in the literature, this handbook provides comprehensive coverage of properties, fabrication, characterization, functionalization methods and applications at both experimental and theoretical models scales. Economic, toxicological, regulatory, and environmental concerns regarding applications are also discussed in detail. Special attention is paid to sustainable approaches that reduce costs in terms of chemicals and time consumption. The book covers research trends, challenges, and prospective topics as well.

Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, ­biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer ­therapeutics—featuring discussion of current problems, ­proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

The past two decades have seen a surge in the development and application of nanoparticles for biomedical uses, with a focused effort on engineering particles for ‘theranostic’ applications where diagnosis and disease treatment are possible using a single platform. Magnetic nanoparticles, in particular, are ideal candidates for this kind of multimodal action, given their potential use spans magnetic resonance (MR) imaging, magnetic hyperthermia and targeted drug delivery. This is due to unique properties their size bestows on them. Here, we examine these properties of magnetic nanoparticles and how they govern the particle efficacy for a desired application. Given the intimate link between synthetic approach chosen and subsequent properties, we will also discuss typical and emerging routes to magnetic nanoparticle preparation. We will, in detail, describe the uses of magnetic nanoparticles as diagnostic and therapeutic tools, with particular emphasis on their use as MR contrast agents and the most recent developments in targeted drug delivery. Finally, we will present an outlook for the future of these important materials.

The syntheses and characterizations of biocompatible luminescent magnetic iron oxide nanoparticles has drawn particular attention as diagnostic and drug delivery tools for treatment of cancer and many other diseases. This chapter focuses on the chemical synthetic methods, magnetic and luminescent properties, including the biomedical applications of iron oxide nanomaterials and luminescent magnetic iron oxide-based nanocomposite materials. The influences of functionalizing with short ligands such as dopamine and L-cysteine on the magnetic properties of synthesized nanoparticles are described. The chapter contains some data on necessary reagents and protocols for bioconjugation aimed at cell culture and step by step the MTT assays used to evaluate cytotoxicity are also presented. In the final section of the chapter, we focus on the biomedical applications specifically for diagnosis and treatment of breast cancer treatment. This chapter also investigates the application of various characterization techniques for analysis of the structural, optical and magnetic properties of the iron oxide nanoparticles and as their nanocomposites.

Magnetic nanoparticles (MNPs) have many applications in the biomedical field because of their non-toxicity, high chemical stability, and biocompatibility. They are used in DNA or protein separation, hyperthermia, tissue engineering, magnetic resonance imaging, cancer therapy, drug delivery, bone and dental repair, biosensors, etc. The book focuses on magnetic nanoparticles and coated nanoparticles (ferrites nanoparticles, bimetallic-magnetic nanoparticles, magnetic fluid); their synthesis, characterization, and in vivo or in vitro biomedical applications. Keywords: Iron Oxide Magnetic Nanomaterials, Magnetic Spinel Ferrite Nanoparticles, Magnetic Oxide Nanoparticles, Ferromagnetic Nickel Nanostructures, Cobalt Ferrite with Niobium Pentoxide, Hyperthermia, Oncologic Magnetic Thermotherapy, Cancer Therapy, Cancer Diagnosis, Drug Delivery. Immune System Related Diseases.

In this book, cancer theranostics applications of magnetic iron oxide nanoparticles are overviewed in detail. Moreover, their synthesis, characterization, multifunctionality, disease targeting, biodistribution, pharmacokinetics and toxicity have been briefly highlighted. Finally, we have mentioned the current examples of clinical trials of magnetic nanoparticles in cancer theranostics, along with their future scopes and challenges. Part of IOP Series in Photomedicine and Biophotonics

This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.