Magnetic Resonance Microscopy 1 Four Dimensional Spectral Spatial Imaging 2 Diffusional Effects In Magnetic Resonance Microscopy

This handbook and ready reference covers materials science applications as well as microfluidic, biomedical and dental applications and the monitoring of physicochemical processes. It includes the latest in hardware, methodology and applications of spatially resolved magnetic resonance, such as portable imaging and single-sided spectroscopy. For materials scientists, spectroscopists, chemists, physicists, and medicinal chemists.

In the past two decades, significant advances in magnetic resonance microscopy (MRM) have been made possible by a combination of higher magnetic fields and more robust data acquisition technologies. This technical progress has enabled a shift in MRM applications from basic anatomical investigations to dynamic and functional studies, boosting the use of MRM in biological and life sciences. This book provides a simple introduction to MRM emphasizing practical aspects relevant to high magnetic fields. It focuses on biological applications and presents a number of selected examples of neuroscience applications. The text is mainly intended for those who are beginning research in the field of MRM or are planning to incorporate high-resolution MRI in their neuroscience studies.

Magnetic Resonance Microscopy Explore the interdisciplinary applications of magnetic resonance microscopy in this one-of-a-kind resource In Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science and Energy Research, a team of distinguished researchers delivers a comprehensive exploration of the use of magnetic resonance microscopy (MRM) and similar techniques in an interdisciplinary milieux. Opening with a section on hardware and methodology, the book moves on to consider developments in the field of mobile nuclear magnetic resonance. Essential processes, including filtration, multi-phase flow and transport, and a wide range of systems – from biomarkers via single cells to plants and biofilms – are discussed next. After a fulsome treatment of MRM in the field of energy research, the editors conclude the book with a chapter extoling the virtues of a holistic treatment of theory and application in MRM. Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science and Energy Research also includes: A thorough introduction to recent developments in magnetic resonance microscopy hardware and methods, including ceramic coils for MR microscopy Comprehensive explorations of applications in chemical engineering, including ultra-fast MR techniques to image multi-phase flow in pipes and reactors Practical discussions of applications in the life sciences, including MRI of single cells labelled with super paramagnetic iron oxide nanoparticles In-depth examinations of new applications in energy research, including spectroscopic imaging of devices for electrochemical storage Perfect for practicing scientists from all fields, Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science and Energy Research is an ideal resource for anyone seeking a one-stop guide to magnetic resonance microscopy for engineers, life scientists, and energy researchers.

Improvements in the information content of nuclear magnetic resonance (NMR) images have recently been sought through the development of new contrast mechanisms for magnetic resonance imaging (MRI) and NMR microscopy. This thesis addresses the role of molecular diffusion in NMR and develops new methods to obtain image contrast and to infer diffusional action. NMR microscopy of liquid samples provides a means of imaging the spatial distribution of the magnetization arising from nuclei in the liquid, at a resolution of several microns. Usually, the effect of molecular diffusion in NMR microscopy is to degrade resolution and sensitivity due to destructive interference of signals from the moving spins. In this thesis it is demonstrated, both theoretically and experimentally, that diffusional barriers, such as exist in biological tissues, can be made to appear extraordinarily bright in NMR micrographs. These effects are described by the line shape function of the magnetization signal, and by numerical evaluation of the diffusive phase dispersion of the signal. This "edge enhancement" provides a means of visualizing structures as thin and permeable as cell membranes which would otherwise be invisible in NMR microscopy. In the realm of clinical MRI, a description of nuclear spin relaxation mediated by MRI contrast agents and transport processes in compartmentalized systems is given. The relaxation-enhancing action of contrast agents can be most generally explained by exchange and diffusional dephasing, and simple analytic expressions are derived for typical situations. More complex solutions are obtained by efficient numerical methods, including the so-called generalized moment expansion. For appropriate models, it is demonstrated that while the extended influence of contrast agents through diffusion of water can contribute to blurring, such a loss of contrast may be avoided if the multiexponential character of the signal decay is exploited.

This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.

The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

This is the final report for Office of Naval Research Contract N0001495-C- 0124. Work under this recently completed contract has focused on improving the basic technology of magnetic resonance force microscopy (MRFM) and working towards the dual goals of dopant detection ill silicon and single electron spin detection. In addition, a number of important advances were achieved, including ultrasensitive force detection, magnetic resonance characterization of dangling bond defects in SiO2, and two and three-dimensional imaging of both paramagnetic and ferromagnetic resonance on the micronscale. Magnetic resonance force microscopy1, 2, 3 (MRPM) is a new scanning probe microscope technique that combines aspects of magnetic resonance imaging (MRI) and atomic force microscopy (APM). IBM's interest in MRFM is driven by the possibility of achieving non-invasive, three-dimensional imaging with atomic-resolution and elemental selectivity. If this goal can be realized, the technique would have a revolutionary impact on the field of microscopy and have many important applications. Potential applications include: 1) determining the sub-surface, three-dimensional structure of solid state materials, 2) imaging three-dimensional distributions of dopants in semiconductors with angstrom spatial resolution, 3) imaging defects and trapping sites in semiconductors, 4) imaging interactions between polymer molecules, 5) determining the three-dimensional atomic structure of macromolecules, such as proteins.