Macrophages Cancer
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Author | : Maurie Markman |
Publisher | : Springer Science & Business Media |
Total Pages | : 363 |
Release | : 2000-01-02 |
Genre | : Medical |
ISBN | : 1592592198 |
Download Regional Chemotherapy Book in PDF, Epub and Kindle
Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.
Author | : Alberto Mantovani |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 43 |
Release | : 2013-06-04 |
Genre | : Medical |
ISBN | : 0128059230 |
Download Cancer Immunotherapy Book in PDF, Epub and Kindle
Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.
Author | : Toby Lawrence |
Publisher | : Springer Science & Business Media |
Total Pages | : 189 |
Release | : 2011-10-06 |
Genre | : Medical |
ISBN | : 1461406625 |
Download Tumour-Associated Macrophages Book in PDF, Epub and Kindle
The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development.
Author | : Gloria H. Heppner |
Publisher | : CRC Press |
Total Pages | : 229 |
Release | : 2019-06-04 |
Genre | : Medical |
ISBN | : 1000006158 |
Download Macrophages & Cancer Book in PDF, Epub and Kindle
First Published in 1988, this book offers a full, comprehensive guide into the relationship between macrophages and Cancer. Carefully compiled and filled with a vast repertoire of notes and references this book serves as a useful reference for Students of Medicine, Oncology and other practitioners in their respective fields.
Author | : G. Mathe |
Publisher | : Springer Science & Business Media |
Total Pages | : 266 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642810497 |
Download Lymphocytes, Macrophages, and Cancer Book in PDF, Epub and Kindle
Fresh living Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them highly cytotoxic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irrespective of the dose of BCG injected. The inhibitory effect was shown to be mediated by suppressor cells which had characteristics of macrophages since they could be removed by carbonyl iron and magnet treatment and were adherent to plastic. In contrast to it was observed after injec tion of 1 mg of BCG, these suppressor cells alone did not account for the depression of T-cell re.sponses induced by higher doses of BCG. Nylon-nonadherent cell populations obtained from spleen cells treated with 3 or 5 mg BCG partially retained the inhibitory activity suggesting that suppressor T cells were also induced after injection of high doses of BCG. In contrast, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen cells were not affected or significantly enhanced depending on the dose of BCG injected.
Author | : Barrett Rollins |
Publisher | : Springer Science & Business Media |
Total Pages | : 346 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Download Chemokines and Cancer Book in PDF, Epub and Kindle
Since the introduction of microscopy, pathologists have noted tumor infiltration by inflammatory cells and presumed that this represents the host's attempt to reject its tumor. Recent advances in the molecular biology of inflammation have revealed the signals involved in attracting inflammatory cells to tumors and, for the most part, these signals are mediated by chemokines and their receptors. Chemokines are low molecular weight proteins that attract and activate specific subsets of leukocytes to the exclusion of others.
Author | : Bernd Kaina |
Publisher | : Frontiers Media SA |
Total Pages | : 129 |
Release | : 2023-06-01 |
Genre | : Medical |
ISBN | : 2832524680 |
Download The role of tumor-associated macrophages in tumor progression Book in PDF, Epub and Kindle
Author | : Mariano Bizzarri |
Publisher | : Springer Nature |
Total Pages | : 493 |
Release | : 2020-04-17 |
Genre | : Medical |
ISBN | : 3030328570 |
Download Approaching Complex Diseases Book in PDF, Epub and Kindle
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Author | : Mary Fink |
Publisher | : Elsevier |
Total Pages | : 276 |
Release | : 2012-12-02 |
Genre | : Medical |
ISBN | : 0323158153 |
Download The Macrophage In Neoplasia Book in PDF, Epub and Kindle
The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.
Author | : |
Publisher | : |
Total Pages | : 200 |
Release | : 2011-10-06 |
Genre | : |
ISBN | : 9781461406631 |
Download Tumour-Associated Macrophages Book in PDF, Epub and Kindle