Exploiting Biotechnology

Supplies basic knowledge of biotechnology; how products are chosen, manufactured and marketed as well as how new avenues for development are identified and managed. The authors discuss in simple, non-technical language the most relevant aspects of biology and chemistry, and go on to survey significant developments in biotechnology in recent years together with those likely to bear fruit in the years to come. Combined with technology, chapters on management, manufacturing, patents, regulation and public attitudes complete the picture.

Both macro- and microeconomic aspects of biotechnology are discussed in this book for biologists studying microbiology, biochemistry and genetics. It explains economics and accounting procedures from first principles and assumes no prior knowledge of these areas. The author works on developing new biotechnological projects. He draws extensively on his own experience and brings together the factors which determine commercial reasoning towards biotechnology in areas such as markets, project selection, costing and capital investment. His subjects include market analysis, fermentation, enzyme technology, genetic engineering and many others; they are all tied together by a common framework of industrial and technological development.

Focuses on: Australia, Canada, China, India, Japan, the United States, Europe, France, Germany, Italy, the Netherlands, and the United Kingdom.

From self-help books and nootropics, to self-tracking and home health tests, to the tinkering with technology and biological particles - biohacking brings biology, medicine, and the material foundation of life into the sphere of »do-it-yourself«. This trend has the potential to fundamentally change people's relationship with their bodies and biology but it also creates new cultural narratives of responsibility, authority, and differentiation. Covering a broad range of examples, this book explores practices and representations of biohacking in popular culture, discussing their ambiguous position between empowerment and requirement, promise and prescription.

This book embodies 21 review articles contributed by subject experts of various areas of industrial microbiology. The articles are devoted to pharma industries, food and enzyme industries, textile industry, agro-industry and cottage industry. Yeast is one of the important microorganisms which have been used to produce beverages, alcohols and fermented food commodities for a very long time. In recent years, it has been the first choice among eukaryotes to use in recombinant technology. Yeast and Spirulina are being used and marketed as Single Cell Protein (SCP). Mushrooms have been used by humans down the ages. In addition to a rich source of mycoprotein, they have medicinal values also against many ailments. Number of bioactive novel compounds is increasing with the discovery of microbial species and newer groups of microorganisms. Some chapters are devoted to microbial bioinoculants used as biofertilizers because they are rich source of nitrogen and phosphorus for both legumes and non-legumes. They are being manufactured and sold in market with different trade names. In addition, several microbial enzymes have been produced and commercialized by various industries, but highly active and potential enzymes produced through recombinant DNA technology hold much importance. For example, microbial proteases find application in detergent leather, food and pharma industries and provide eco-friendly technology for bioremediation. Laccase has been worked out to be a good tool for bioremediation of non-degradable wastes and xenobiotic chemicals. Besides, laccase-based biosensors have also been constructed which can be used for phenol determination, monitoring of lignin and plant flavonoids. Various microbial phytases as feed supplemented have been used in freshwater and marine aquaculture for improving the growth performance of fishes. Nowadays aquaculture is growing rapidly to meet increasing food demand throughout the world for high quality fish. More than 16,000 bioactive compounds have been isolated from actinomycetes alone including antibiotics, enzymes, vitamins, amino acids, siderophores and nanoparticles. Biosynthesis of nanoparticles by bacteria, actinomycetes and algae has been reported and work is being done nationally and internationally.

Microbiology may be described as one of the younger sciences with its history, as a precise subject, only dating as far back as Pasteur in the mid 1800s and his revelation both of the role of microorganisms in nature and their importance to human welfare. Medical scientists rapidly took up the challenge, with their area of microbiology flourishing and expanding almost in complete isolation from the rest of biology. We now know, of course, that microorganisms have always played an important, if not essential role, in the biosphere with fermented foods and beverages, plant and animal diseases and nutrient cycling foremost in their sphere of activities. Within the last twenty years, microbiology has received two enormous boosts with the developments in microbial genetics and genetic engineering probably being the most influential, and the greater awareness of pollution and environmental sustainability following a close second. In 1990, your editor had the privilege and pleasure of being elected as President of The Association of Applied Biologists in the United King dom and, as the topic for his three-day Presidential Conference, chose 'The exploitation of microorganisms in applied biology'. This meeting stimu lated great interest in a wide range of subject areas, from weed control to nematology, from plant breeding to plant pathology, from mushrooms to mycorrhiza. The proceedings of this meeting were published in Aspects of Applied Biology, No. 24, 1990.

Fungi playa major role in the sustainability of the biosphere, and mycorrhizal fungi are essential for the growth of many of our woods and forests. The applications of fungi in agriculture, industry and biotechnology remain of paramount importance, as does their use as a source of drugs and to help clean up our environment. This volume contains key papers from the conference 'From Ethnomycology to Fungal Biotechnology: Exploiting Fungi from Natural Resources for Novel Products'. This was the first international scientific conference covering the transfer of traditional remedies and processes in ethnomycology to modern fungal biotechnology. The conference was held at Simla, Himachal Pradesh, India from 15 to 16 December 1997. The key subject areas addressed in the conference were the issues of exploring and exploiting fungal diversity for novel leads to new antibiotics, enzymes, medicines and a range of other leads for wood preservation, biological control, agricultural biotechnology and the uses of fungi in the food industry. The conference programme included key-note presentations followed by poster sessions and general discussion. The book is broadly based, covering five main areas: Ethnomycology, Fungal Biotechnology, Biological Control, Mycorrhizal Fungi and Fungal Pests. There is no doubt that in the past fungi have played a key role in ethnomycological remedies and that in the future they will continue to attract the interest of a wide range of disciplines ranging from environmental conservation, agriculture and the food industry to wood preservation and aerobiological studies.

The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.