Cellular And Biomolecular Recognition
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Author | : Raz Jelinek |
Publisher | : John Wiley & Sons |
Total Pages | : 368 |
Release | : 2009-07-10 |
Genre | : Science |
ISBN | : 3527627022 |
Download Cellular and Biomolecular Recognition Book in PDF, Epub and Kindle
With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.
Author | : Anna Rita Bizzarri |
Publisher | : CRC Press |
Total Pages | : 288 |
Release | : 2012-01-25 |
Genre | : Science |
ISBN | : 1439862370 |
Download Dynamic Force Spectroscopy and Biomolecular Recognition Book in PDF, Epub and Kindle
Molecular recognition, also known as biorecognition, is the heart of all biological interactions. Originating from protein stretching experiments, dynamic force spectroscopy (DFS) allows for the extraction of detailed information on the unbinding process of biomolecular complexes. It is becoming progressively more important in biochemical studies and is finding wider applications in areas such as biophysics and polymer science. In six chapters, Dynamic Force Spectroscopy and Biomolecular Recognition covers the most recent ideas and advances in the field of DFS applied to biorecognition: Chapter 1: Reviews the basic and novel aspects of biorecognition and discusses the emerging capabilities of single-molecule techniques to disclose kinetic properties and molecular mechanisms usually hidden in bulk measurements Chapter 2: Describes the basic principle of atomic force microsocopy (AFM) and DFS, with particular attention to instrumental and theoretical aspects more strictly related to the study of biomolecules Chapter 3: Overviews the theoretical background in which experimental data taken in nonequilibrum measurements of biomolecular unbinding forces are extrapolated to equilibrium conditions Chapter 4: Reviews the most common and efficient strategies adopted in DFS experiments to immobilize the interacting biomolecules to the AFM tip and to the substrate Chapter 5: Presents and discusses the most representative aspects related to the analysis of DFS data and the challenges of integrating well-defined criteria to calibrate data in automatic routinary procedures Chapter 6: Overviews the most relevant DFS applications to study biorecognition processes, including the biotin/avidin pair, and selected results on various biological complexes, including antigen/antibody, proteins/DNA, and complexes involved in adhesion processes Chapter 7: Summarizes the main results obtained by DFS applied to study biorecognition processes with forthcoming theoretical and experimental advances Although DFS is a widespread, worldwide technique, no books focused on this subject have been available until now. Dynamic Force Spectroscopy and Biomolecular Recognition provides the state of the art of experimental data analysis and theoretical procedures, making it a useful tool for researchers applying DFS to study biorecognition processes.
Author | : JASON A. MCEVOY |
Publisher | : Lulu.com |
Total Pages | : 322 |
Release | : 2011 |
Genre | : Chemistry |
ISBN | : 0359602312 |
Download MOLECULAR RECOGNITION: BIOTECHNOLOGY, CHEMICAL ENGINEERING AND MATERIALS APPLICATIONS Book in PDF, Epub and Kindle
Author | : Dipankar Chatterji |
Publisher | : CRC Press |
Total Pages | : 139 |
Release | : 2016-04-05 |
Genre | : Medical |
ISBN | : 1482219697 |
Download Basics of Molecular Recognition Book in PDF, Epub and Kindle
Basics of Molecular Recognition explores fundamental recognition principles between monomers or macromolecules that lead to diverse biological functions. Based on the author's longtime courses, the book helps readers understand the structural aspects of macromolecular recognition and stimulates further research on whether molecules similar to DNA o
Author | : Yoo-Jin Ghang |
Publisher | : |
Total Pages | : 174 |
Release | : 2015 |
Genre | : Cellular recognition |
ISBN | : 9781339183039 |
Download Molecular Recognition by Synthetic Receptors in Biomimetic and Cellular Systems Book in PDF, Epub and Kindle
To study the scope of guests that can be recognized, several proteins were functionalized with R-NMe3+ binding handles and the recognition event between the functionalized proteins and cavitand:SLB system was monitored by Surface Plasmon Resonance (SPR) Spectroscopy. The binding was monovalent, and displayed a binding affinity of>105 M-1, showing that the cavitand is capable of recognizing suitably labeled large proteins via cavity-based recognition.
Author | : Gregory R. Bock |
Publisher | : John Wiley & Sons |
Total Pages | : 304 |
Release | : 2008-04-30 |
Genre | : Science |
ISBN | : 0470513837 |
Download Carbohydrate Recognition in Cellular Function Book in PDF, Epub and Kindle
Contributors to this volume explore the role of carbohydrates in communication between cells of multicellular organisms. Topics covered include the thermodynamics and spatial restrictions of oligosaccharide-protein interactions, the role of carbohydrates in recognition and as components of cell adhesion molecules, and abnormal glycosylation in several disease states.
Author | : Mohammed Zourob |
Publisher | : Springer Science & Business Media |
Total Pages | : 864 |
Release | : 2010-01-08 |
Genre | : Technology & Engineering |
ISBN | : 1441909192 |
Download Recognition Receptors in Biosensors Book in PDF, Epub and Kindle
Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.
Author | : Richard James Gamblin |
Publisher | : |
Total Pages | : 300 |
Release | : 2006 |
Genre | : |
ISBN | : |
Download Molecular Recognition Mechanisms in DNA Binding Protein Families, Using Molecular Modelling Techniques Book in PDF, Epub and Kindle
Author | : Vincent Rotello |
Publisher | : John Wiley & Sons |
Total Pages | : 492 |
Release | : 2008-09-15 |
Genre | : Science |
ISBN | : 0470384042 |
Download Molecular Recognition and Polymers Book in PDF, Epub and Kindle
State-of-the-art techniques for tapping the vast potential of polymers The use of specific non-covalent interactions to control polymer structure and properties is a rapidly emerging field with applications in diverse disciplines. Molecular Recognition and Polymers covers the fundamental aspects and applications of molecular recognition—in the creation of novel polymeric materials for use in drug delivery, sensors, tissue engineering, molecular imprinting, and other areas. This reference begins by explaining the fundamentals of supramolecular polymers; it progresses to cover polymer formation and self-assembly with a wide variety of examples, and then includes discussions of biomolecular recognition using polymers. With chapters contributed by the foremost experts in their fields, this resource: Provides an integrated resource for supramolecular chemistry, polymer science, and interfacial science Covers advanced, state-of-the-art techniques used in the design and characterization of non-covalent interactions in polymers Illustrates how to tailor the properties of polymeric materials for various applications Stand-alone chapters address specific applications independently for easy reference. This is a premier resource for graduate students and researchers in polymer chemistry, supramolecular chemistry, materials science, and physical organic chemistry.
Author | : Paolo Ugo |
Publisher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 414 |
Release | : 2021-02-08 |
Genre | : Technology & Engineering |
ISBN | : 311058929X |
Download Bioanalytical Chemistry Book in PDF, Epub and Kindle
Bioanalytical chemistry plays today a central role in various fields, from healthcare to food and environmental control. This book presents the main methodologies for analyzing biomacromolecules, with a focus on methods based on molecular recognition. The six chapters move from fundamentals to the most recent advances, achieved by a synergetic combination of bio and nanotechnologies. The need for rapid and reliable analytical tools able to perform a large number of quantitative analyses, not only in centralized laboratories and core facilities but also for point-of-care testing, has been dramatically stressed by the recent crisis caused by the COVID-19 pandemic. The aim of the authors is to provide graduate students and young researchers with the elements of interdisciplinary knowledge necessary not only to use the wide arsenal of bioanalytical tools available today but also to contribute to the development of even more effective devices and methods.