Binding of gold(I) compounds to human serum albumin
Author | : Susanne Møller Pedersen |
Publisher | : |
Total Pages | : 38 |
Release | : 1988 |
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Author | : Susanne Møller Pedersen |
Publisher | : |
Total Pages | : 38 |
Release | : 1988 |
Genre | : |
ISBN | : |
Author | : Susanne Møller Pedersen |
Publisher | : |
Total Pages | : 46 |
Release | : 1988 |
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Although preliminary data on some novel gold compounds indicate good antiviral activity, further information is required for them to be considered promising lead candidates. As part of our interest in the elucidation of the mode of action of gold based compounds, this work aims to investigate the binding properties of novel gold complexes to human serum albumin (HSA) using saturation transfer difference (STD) NMR technique.
Author | : |
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Total Pages | : 4 |
Release | : 1758 |
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Publisher | : Academic Press |
Total Pages | : 489 |
Release | : 1994-03-10 |
Genre | : Science |
ISBN | : 0080582184 |
This volume contains eight chapters that present both new and reviewed information fundamental to a clear understanding of lipid catabolism and transport at the molecular level. Three-dimensional structures of important serum lipoproteins, apolipoproteins, and lipases, utilizing X-ray data when available, are emphasized, and an attempt is made to relate structures to function. Amphipathic helix Apolipoprotein E Lipophorin Structure of serum albumin Lipid binding proteins Apolipoprotein B Low-density lipoprotein
Author | : Li Di |
Publisher | : Elsevier |
Total Pages | : 549 |
Release | : 2010-07-26 |
Genre | : Science |
ISBN | : 0080557619 |
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Author | : Vidya A. Sagar |
Publisher | : |
Total Pages | : 88 |
Release | : 1977 |
Genre | : Binding sites (Biochemistry) |
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Author | : Alain Steiner |
Publisher | : |
Total Pages | : 178 |
Release | : 1990 |
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Author | : Theodore Peters Jr. |
Publisher | : Academic Press |
Total Pages | : 455 |
Release | : 1995-12-21 |
Genre | : Science |
ISBN | : 0080527043 |
The first of its kind, All About Albumin summarizes the chemistry, genetics, metabolism, clinical implications, and commercial aspects of albumin. It provides the most up-to-date sequences, structures, and compositions of many species, and includes more than 2000 references. Includes up-to-date sequences, structures, and compositions of many species Reviews the protein chemistry, genetic control, and metabolism of albumin Covers medical and cell culture applications in vivo and in vitro, with a section on handling albumin in the laboratory Presents the relationship of albumin to its superfamily with an updated scheme for their evolution First complete coverage of all aspects of serum albumin in one volume, with more than 2000 references
Author | : David Ismet Daikh |
Publisher | : |
Total Pages | : 166 |
Release | : 1982 |
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