Applied Uses of Ancient DNA
Author | : Nic Rawlence |
Publisher | : Frontiers Media SA |
Total Pages | : 183 |
Release | : 2021-06-17 |
Genre | : Science |
ISBN | : 2889669335 |
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Author | : Nic Rawlence |
Publisher | : Frontiers Media SA |
Total Pages | : 183 |
Release | : 2021-06-17 |
Genre | : Science |
ISBN | : 2889669335 |
Author | : Susanne Hummel |
Publisher | : Springer Science & Business Media |
Total Pages | : 320 |
Release | : 2013-03-09 |
Genre | : Social Science |
ISBN | : 3662050501 |
This is the definitive source of information on techniques for the identification and sequencing of old DNA (pieces) and their use in biological and medical research and application. Application of aDNA techniques are useful tools for investigations reaching from evolutionary studies to law enforcement approaches. What brings them together is the interest in specific methods of handling aDNA, i.e. elaborated PCR and sequencing techniques and the interpretation of the results. This books serves as an ideal guideline for it demonstrates how problem-solving strategies can be applied in various areas.
Author | : Bernd Herrmann |
Publisher | : Springer Science & Business Media |
Total Pages | : 275 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461243181 |
Ancient DNA refers to DNA which can be recovered and analyzed from clinical, museum, archaeological and paleontological specimens. Ancient DNA ranges in age from less than 100 years to tens of millions of years. The study of ancient DNA is a young field, but it has been revolutionized by the application of polymerase chain reaction technology, and interest is growing very rapidly. Fields as diverse as evolution, anthropology, medicine, agriculture, and even law enforcement have quickly found applications in the recovery of ancient DNA. This book contains contributions from many of the "first generation" researchers who pioneered the development and application of ancient DNA methods. Their chapters present the protocols and precautions which have resulted in the remarkable results obtained in recent years. The range of subjects reflects the wide diversity of applications that are emerging in research on ancient DNA, including the study of DNA to analyze kinship, recovery of DNA from organisms trapped in amber, ancient DNA from human remains preserved in a variety of locations and conditions, DNA recovered from herbarium and museum specimens, and DNA isolated from ancient plant seeds or compression fossils. Ancient DNA will serve as a valuable source of information, ideas, and protocols for anyone interested in this extraordinary field.
Author | : Erika Hagelberg |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : DNA, Fossil |
ISBN | : 9781782521099 |
Author | : Beth Alison Shapiro |
Publisher | : |
Total Pages | : 247 |
Release | : 2012-01-01 |
Genre | : Nature |
ISBN | : 9781617795169 |
Ancient DNA presents an overview of the many of the protocols commonly used to study ancient DNA. These include laboratory instructions, extraction protocols, laboratory techniques, and suggestions for appropriate analytical approaches to make sense of the sequences obtained.
Author | : Alexander Immel |
Publisher | : |
Total Pages | : 0 |
Release | : 2020* |
Genre | : |
ISBN | : |
Ancient DNA has become an indispensable resource of fundamental research. Especially the combination of DNA capture methods and Next Generation Sequencing (NGS) has allowed to exploit the full potential of ancient DNA. In this dissertation I present three studies which involve capture of ancient DNA to answer different scientific questions. In my first study I bioinformatically reconstruct the mitochondrial genome of the extinct giant deer Megaloceros giganteus after applying mitochondrial DNA capture and sequencing. Using the giant deer's reconstructed mitochondrial genome I then apply phylogenetic analyses that allow to resolve the giant deer's placement within the cervid family tree and reaffirm the fallow deer being its closest extant relative. Mitochondrial DNA capture also provides the basis for the next study, in which I investigate the effects of X-rays on ancient DNA. Different radiation settings are explored including those commonly used in computed tomography (CT) of anthropological and palaeontological specimens. The results allow to define 200 Gray (Gy) as the maximum absorbed X-ray dose which can still be regarded harmless to ancient DNA molecules. No X-radiation induced effects can be observed below this threshold. In my third study I develop and apply capture of 488 human immunity genes in order to compare the immunogenetic makeup of Late Medieval plague (Yersinia pestis) victims and their modern day successors from Ellwangen, Southern Germany. Applying bioinformatic tools allows me to investigate kinship within both populations, determine genetic continuity between past and present, and reconstruct the Human Leukocyte Antigen (HLA) allelic profiles of both populations. While the majority of HLA alleles do not differ in their frequencies, HLA-B51:01 and HLA-DRB113 show significant frequency differences between both populations, potentially indicative of selective pressure through Yersinia pestis.
Author | : D. R. Lees |
Publisher | : Academic Press |
Total Pages | : 346 |
Release | : 1993 |
Genre | : Science |
ISBN | : |
Evolution is the central theme of all biology. Researcarcch in the many branches of evolutionary study continues to flourish. This book, based on a symposium of the Linnean Society, discusses the diversity in currentevolutionary research. It approaches the subject ambitiously and from several angles, bringing ttogether eminent authors from a variety of disciplines paleontologists traditionally with a macroevolutionary bias, neontologists concentrating on microevolutionary processes, and those studying the very essence ofsses and those studying the very essence of evolution the process of speciation in living organisms. Evolutionary Patterns and Processes will appeal to a broad spectrum of professional biologistsworking in such fields as paleontology, population biology, and evolutionary genetics. Biologists will enjoy chapters by Stephen J. Gould, discovering in the much earlier work of Hugo de Vries parallels with his ideas on punctuational evolution; Guy Bush,considering why there are so many small animals; Peter Sheldon, examining detailed fossil trilobite sequences for evidence of microevolutionary processes and considering models of speciation; as well as others dealing with cytological, ecological, and behavioral processes leading to the evolution of new species. None
Author | : Jennifer Ann Leonard |
Publisher | : |
Total Pages | : 392 |
Release | : 2002 |
Genre | : |
ISBN | : |
Author | : David Reich |
Publisher | : Oxford University Press |
Total Pages | : 320 |
Release | : 2018-03-29 |
Genre | : Science |
ISBN | : 0192554387 |
The past few years have witnessed a revolution in our ability to obtain DNA from ancient humans. This important new data has added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations living today are mixes of ancient ones, and often carry a genetic component from archaic humans. David Reich, whose team has been at the forefront of these discoveries, explains what genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial âpurity.' Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?
Author | : Elizabeth D. Jones |
Publisher | : Yale University Press |
Total Pages | : 279 |
Release | : 2022-03-29 |
Genre | : SCIENCE |
ISBN | : 0300240120 |
"The story of the search for DNA and protein molecules from fossils, along with the controversy and celebrity that have followed it, helping to define the formation of a new scientific field now widely known as "ancient DNA research.""--