Wound Healing Fibrosis And The Myofibroblast

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). This book aims to draw a concise yet complete description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to present time, as well as commenting on the role of the myofibroblast and the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history). By viewing this complex and century-long history from different perspectives, the book's authors aim to draw an exhaustive overview, with the hope of inspiring new and fruitful basic and clinical research. Interdisciplinary collaboration: complementary views from medical historian, a physician and a researcher A concise but detailed history of fibrosis, readers can discover the major scientific breakthroughs along this history Includes the pathophysiology of various fibrotic diseases Explores the role of myofibroblast in fibrosis development

Wound Healing, Fibrosis and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). A book aims to draw a concise, yet complete, description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to current time, as well as of the role of the myofibroblast, the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history). By viewing this complex and centuries-long history from different perspectives, the Authors aim to draw an exhaustive overview, with the hope of inspiring new fruitful basic and clinical research. Interdisciplinary collaboration: Complementary views from a medical historian, a researcher and a clinician A concise but detailed history of fibrosis, readers can discover the major scientific breakthroughs along this history Includes the pathophysiology of various Fibrotic Diseases Explore the role of Myofibroblast in Fibrosis Development

With contributions by numerous experts

Tissue Repair, Contraction and the Myofibroblast summarizes the latest findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. Coverage shows that the myofibroblast is responsible for the development of hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma. Reviews the cell biology and pathology of the myofibroblast as well as mechanisms of fibrosis evolution in many organs and tissues.

A comprehensive resource on the recent developments of stem cell use in wound healing With contributions from experts in the field, Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds. Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource: Provides a comprehensive overview of stem cell use in wound healing, including both the basic and translational aspects of the field Covers recent developments and emerging subtopics within the field Offers an invaluable resource to clinical and basic researchers who are interested in wound healing, stem cells, and regenerative medicine Contains contributions from leading experts in the field of wound healing and care Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.

This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners

Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

'Provides comprehensive detail on the various aspects of particular molecules involved in the phases of injury and repair and the cellular movements and processes....This is an excellent reference book for libraries serving biology and health science clientele and for workers in this field of research.' -American Scientist, from a review of the First Edition All chapters of this second edition have been completely revised and expanded-especially the chapters on growth factors and extracellular matrix molecules. New chapters discuss provisional matrix proteins, extracellular matrix receptors, and scarring versus nonscarring wound healing.

Myofibroblasts play a major role in connective tissue remodeling by synthesizing the extracellular matrix (ECM) and by exerting contraction, both of which depend on complex and specific cell-matrix and cell-cell communications. Integrins are a major family of transmembrane receptors that directly link the intracellular cytoskeleton dynamics to extracellular structures via adhesions in all metazoans. In this book, Chapter One discusses major integrins that have an established role in the formation, function, and turnover of myofibroblasts associated with tissue remodeling. Chapter Two reviews the role of myofibroblasts in normal skin wound healing. Chapter Three summarizes the evidence for the presence and role of myofibroblasts in cancer progression and discusses the similarities of myofibroblasts in cancer and fibrosis. Chapter Four focuses on the role of bone marrow stem cells and bone marrow stem cell derived myofibroblasts in carcinogenesis and cancer development, and ways to inhibit the process of malignization.