The Unbound

Each body has a story to tell, a life seen in pictures only Librarians can read. The dead are called Histories, and the vast realm in which they rest is the Archive.Last summer, Mackenzie Bishop, a Keeper tasked with stopping violent Histories from escaping the Archive, almost lost her life to one. Now, as she starts her junior year at Hyde School, she's struggling to get her life back. But moving on isn't easy, not when her dreams are haunted by what happened. She knows the past is past, knows it cannot hurt her, but it feels so real. When her nightmares begin to creep into her waking hours, she starts to wonder if she's truly safe.Meanwhile, people are vanishing without a trace, and the only thing they seem to have in common is Mackenzie. She's sure the Archive knows more than they are letting on, but before she can prove it, she becomes the prime suspect. Unless Mac can track down the real culprit, she'll lose everything: not only her role as Keeper, but her memories – and even her life. Can Mackenzie untangle the mystery before she herself unravels?

For those who struggle with the same sins time and again, a strategy to overcome Satan's influence in your life.

A political scion and her magically bound fire warlock must face their greatest fears to save the Empire from a ruthless enemy in the explosive conclusion of a spellbinding fantasy trilogy from David Gemmell Award-nominated author Melissa Caruso. While winter snows keep the Witch Lord Ruven's invading armies at bay, Lady Amalia Cornaro and the fire warlock Zaira attempt to change the fate of mages in the Raverran Empire forever, earning the enmity of those in power who will do anything to keep all magic under tight imperial control. But in the season of the Serene City's great masquerade, Ruven executes a devastating surprise strike at the heart of the Empire -- and at everything Amalia holds most dear. To stand a chance of defeating Ruven, Amalia and Zaira must face their worst nightmares, expose their deepest secrets, and unleash Zaira's most devastating fire. Praise for Swords and Fire: "Charming, intelligent, fast-moving, beautifully atmospheric, with a heroine and other characters whom I really liked as people. I couldn't put it down."―Genevieve Cogman, author of The Invisible Library "Breathtaking... Worth every moment and every page, and should make anyone paying attention excited about what Caruso will write next."―BookPage "A riveting read, with delicious intrigue, captivating characters, and a brilliant magic system. I loved it from start to finish!"―Sarah Beth Durst, author of The Queen of Blood Swords and Fire The Tethered Mage The Defiant Heir The Unbound Empire For more from Melissa Caruso, check out: Rooks and Ruin The Obsidian Tower

This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.

The word revolution has a number of definitions (The American Heritage Dictionary, 2006). The one most pertinent to this series and volume is 'a sudden or momentous change in a situation'. Recent years have seen an unprecedented explosion of interest in unfolded proteins in all of their various forms. Coupled with this increase in interest we have seen momentous changes in the way unfolded proteins are viewed. Two particular paradigms have come under close scrutiny: unfolded proteins are disordered random coils devoid of persistent structure, and protein function first requires protein structure. The first of these is currently a hotly debated subject. The second paradigm we can safely claim has been overturned. There is a second definition of revolution that is quite relevant to a significant portion of the work reviewed herein, in particular those chapters dealing with local and persistent structure in unfolded proteins. That definition is 'a turning or rotational motion about an axis' (The American Heritage Dictionary, 2006). About four decades ago, Charles Tanford (1968) demonstrated that highly denatured proteins possess hydrodynamic properties consistent with Paul Flory's random coil (Flory, 1969). Given that the Flory random coil definition included the stipulation that conformers making up the denatured state ensemble would differ in energy by just a few kT, there has been the assumption that denatured states must therefore be completely random in nature with no persistent structure or biases towards particular conformers. Notably however, Tanford did note the random coil-like hydrodynamic data he obtained did not necessarily rule out the presence of structure in denatured proteins (Tanford, 1968). Around the same time, Sam Krimm and M. Lois Tiffany noted that the CD spectra they obtained for proteins in the presence of high concentration of chemical denaturants had similarities to spectra obtained for homopolymers of proline, lysine, and glutamic acid in water (Tiffany and Krimm, 1968a, 1968b, 1973, 1974). Homopolymers of these residues were known to adopt the left-handed polyproline II conformation, leading Tiffany and Krimm to hypothesise that highly denatured proteins possess significant polyproline II helix content. Of these two views, that espousing the lack of structure in denatured proteins became more widely adopted and was, over time, adopted as a central paradigm in protein folding. As several of the chapters in this volume note, a Tiffany and Krimm-like view appears to be, to some extent, the more correct one. The level to which it is correct is still unknown, although it is clear that the polyproline II helical conformation is not the only, perhaps not even the most common, persistent conformation present in unfolded proteins. Thus we have come through a full circle or revolution. (from the preface)

A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.

Our ambition in the organization of this book was to explore the current stus of knowledge about nucleic acids in plants. We wanted the reader to be able to learn how this research is being undertaken. Therefore, we asked the contributing authors to include details of approaches and methods. Where feasible, the have provided protocols that can be followed by those who wish to repeat results, extend data, make improvements, or use them in new applications.

For almost a century the concept of guilt, as embedded in drive theory, has dominated psychoanalytic thought. Increasingly, however, investigators are focusing on shame as a key aspect of human behavior. This volume captures a range of compelling viewpoints on the role of shame in psychological development, psychopathology, and the therapeutic process. Donald Nathanson has assembled internationally prominent authorities, engaging them in extensive dialogue about their areas of expertise. Concise introductions to each chapter place the authors both historically and theoretically, and outline their emphases and contributions to our understanding of shame. Including many illustrative clinical examples, the book covers such topics as the relationship between shame and narcissism, shame's central place in affect theory, psychosis and shame, and shame in the literature of French psychoanalysis and philosophy.

Religion and empire were inseparable forces in the early modern Atlantic world. Religious passions and conflicts drove much of the expansionist energy of post-Reformation Europe, providing both a rationale and a practical mode of organizing the dispersal and resettlement of hundreds of thousands of people from the Old World to the New World. Exhortations to conquer new peoples were the lingua franca of Western imperialism, and men like the mystically inclined Christopher Columbus were genuinely inspired to risk their lives and their fortunes to bring the gospel to the Americas. And in the thousands of religious refugees seeking asylum from the vicious wars of religion that tore the continent apart in the sixteenth and seventeenth centuries, these visionary explorers found a ready pool of migrants—English Puritans and Quakers, French Huguenots, German Moravians, Scots-Irish Presbyterians—equally willing to risk life and limb for a chance to worship God in their own way. Focusing on the formative period of European exploration, settlement, and conquest in the Americas, from roughly 1500 to 1760, Empires of God brings together historians and literary scholars of the English, French, and Spanish Americas around a common set of questions: How did religious communities and beliefs create empires, and how did imperial structures transform New World religions? How did Europeans and Native Americans make sense of each other's spiritual systems, and what acts of linguistic and cultural transition did this entail? What was the role of violence in New World religious encounters? Together, the essays collected here demonstrate the power of religious ideas and narratives to create kingdoms both imagined and real.