The Professional Guinea Pig

The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.

The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.

"Endless forms most beautiful and most wonderful have been, and are being, evolved," Darwin famously concluded The Origin of Species, and for confirmation we look to...the guinea pig? How this curious creature and others as humble (and as fast-breeding) have helped unlock the mystery of inheritance is the unlikely story Jim Endersby tells in this book. Biology today promises everything from better foods or cures for common diseases to the alarming prospect of redesigning life itself. Looking at the organisms that have made all this possible gives us a new way of understanding how we got here--and perhaps of thinking about where we're going. Instead of a history of which great scientists had which great ideas, this story of passionflowers and hawkweeds, of zebra fish and viruses, offers a bird's (or rodent's) eye view of the work that makes science possible. Mixing the celebrities of genetics, like the fruit fly, with forgotten players such as the evening primrose, the book follows the unfolding history of biological inheritance from Aristotle's search for the "universal, absolute truth of fishiness" to the apparently absurd speculations of eighteenth-century natural philosophers to the spectacular findings of our day--which may prove to be the absurdities of tomorrow. The result is a quirky, enlightening, and thoroughly engaging perspective on the history of heredity and genetics, tracing the slow, uncertain path--complete with entertaining diversions and dead ends--that led us from the ancient world's understanding of inheritance to modern genetics.

This book provides a comprehensive text covering all aspects of guinea pig medicine. This updated edition will be of value to veterinary surgeons and students, veterinary nurses, breeders and all those working in the animal care industry. Written in note form the book assists in the formulation of a diagnostic plan when the practitioner is faced with a sick animal. Sections on clinical signs, diagnoses and treatments, allow rapid reference in successive chapters on the reproductive, digestive, respiratory, musculoskeletal and urinary systems, the skin, head and neck, nervous system and husbandry. All the latest drug information has been included and full details of dose rates, contraindications and components of the proprietary preparations are listed in chapter 11. A new chapter has been written providing information on herbal and homeopathic remedies.

Guinea pigs have been reared and eaten by indigenous people in the Andes since ancient times, and it seemed rational to development planners to ‘modernize' their production. When these development projects ran into trouble, a team of anthropologists was invited to study the reasons for this lack of success. This intriguing book is the product of that study.What the author shows is that guinea pigs have a meaning in the social and ritual life of Ecuadorian peasants which is far from mundane. Rejecting the attempts of some anthropologists to reduce the production of guinea pigs and the festive life of the Andean community to a quest for protein, he explores the full complex of social and cultural practices which centre on this animal, and uses his study of its role within Andean culture to provide telling insights into how that culture itself is constituted -- its values, beliefs and attitudes. By working in a variety of communities with different ecological and ethnographic characteristics, the author has made a major contribution to ethnographic accounts of Ecuador and to the more general study of ritual, consumption and indigenous knowledge. He points us, in particular, towards the importance of the knowledge of women, who are those principally responsible for the care of an animal which is prized for its role in healing and central to Andean sociality. The book not only presents us with a colourful description of the range of cultural practices surrounding the guinea pig, ranging from the way the animals are reared, through a rich and complex cuisine, to their role in ritual life, but also highlights the way the gender dimension is central to understanding resistances to ‘modernization' and the power of ‘experts'.

"Compact, easy-to-care-for, and a bundle of fun" is how author Virginia Parker Guidry describes the irresistible guinea pig. Ideal pets for families with children, cavies (as they're often called) are clean, odorless, gentle, loving, and entertaining. This Complete Care Made Easy Guinea Pigs encapsulates all the virtues of these perfect small mammals and gives new owners practical advice about how to care for them. In chapter one, "A Guinea What?" the author talks about the guinea pig's natural history;they're neither pigs nor from Guinea, but rather a rodent from Peru;and how scientists classify this very unique mammal. To decide whether the guinea pig is right for you, chapter two discusses who makes the ideal owner and presents thirteen popular breeds of longhaired and shorthaired guinea pigs and the colors available to pet owners today.The chapter "Finding a Healthy Guinea Pig" offers solid advice about selecting the right guinea pig, where to purchase or adopt, and the preferred sex. A complete chapter on preparing for the guinea pig offers the reader excellent advice about acclimating the new pet to the home, selecting the best cage and hutch, and pig-proofing the home. The subject of understanding guinea pig behavior is discussed in the chapter "Living with a Guinea Pig," which also covers daily-care topics such as feeding, grooming, handling, exercise, and litter box training. Keeping the guinea pig healthy is discussed in "Staying Healthy," a chapter that covers preventing illness, choosing a veterinarian, and common ailments. The final chapter "Just for the Fun of It!" explores games, toys, activities, and showing guinea pigs. The appendix includes lists of pig-specific clubs, organizations, and websites. Glossary of terms and index included.

Sasspants, PI(G), the world's fluffiest detective, is back on the case?or she will be, if her sidekick Hamisher can convince her there's really a mystery afoot. Hamisher has made up so many stories, Sasspants doesn't believe him. But one by one the mice in Mr. Venezi's pet shop are going missing, and all the spooky clues point to...a ghost! Once our shaggy Sherlocks start digging for answers, they will stop at nothing to ferret out the truth!

Laboratory animals play an important role in biomedical research and advances. Expanded, updated, and now published in full color to provide greater clarity to the techniques and concepts discussed, this guide presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. It includes additional information on the research uses of the guinea pig along with updated medical care information.