The Non Thrombotic Role Of Platelets In Health And Disease

Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Platelet is a component of blood which is responsible for the initiation of a blood clot in reaction to bleeding occurring from a blood vessel injury. These are also known as thrombocytes because of their role in thrombosis. They also play a role in non-thrombotic disorders. These include non-thrombotic manifestations such as inflammation and cancer. Platelets are continuously recruited at the sites of injury and they regulate inflammatory processes by secreting cytokines and chemokines. They also affect the inflammatory response in cancer by deploying leukocytes at the tumor sites and by influencing the activation status of the endothelium. Platelets take part in the production of neutrophil extracellular traps which can promote metastasis and can contribute to organ failure. This book covers in detail some existent theories and concepts revolving around the role of platelets in non-thrombotic disorders. It will also provide interesting topics for research which interested readers can take up. This book will prove to be immensely beneficial to students and researchers in this field.

Mammalian platelets are small (2–4 um), discoid, short-lived fragments derived from megakaryocyte precursors. They play a crucial role not only in the formation of a normal hemostatic plug but they also play a key role in a much wider repertoire of physiological processes such as inflammation, innate immunity, cancer, infection, neurobiology, and tissue repair/regeneration. Over three sections, the individual chapters in this book identify one particular aspect of platelet function, dysfunction, or application. As significant advances continue to develop our thinking of the functional role of platelets in health and disease, this book elevates awareness and enthusiasm in further investigating these functions.

The present book, which includes eleven articles five reviews and six original studies published in the Special Issue “Molecular Research On Platelet Activity in Health and Disease”, gives an international picture of the up-to-date understanding of (i) platelet signaling under physiological and pathological conditions; (ii) novel technologies for monitoring platelet functions; and (iii) clinical applications of platelet-based-therapy for management of pathological conditions, not directly related to hemostasis and thrombosis. The book reveals novel aspects of platelet biology, and will be helpful for offering new insights and a research impetus for those who are interested in developing new therapeutic tools for the management of pathological conditions depending on platelet dysfunctions.

Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. First edition won Best Book in Medical Science Award from the Association of American Publishers Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.