The Nitro Group In Organic Synthesis

The most useful reactions of organonitro compounds in organic synthesis Compounds containing nitro groups are useful intermediates for the synthesis of natural products and other complex organic molecules. The Nitro Group in Organic Synthesis focuses on reactions that proceed under mild conditions, important functional groups that can be synthesized by conversion of nitro groups, and the stereoselectivity of reactions of nitro compounds. These issues are of great importance to practicing researchers in today's pharmaceutical, agrochemical, and fine chemical industries. The Nitro Group in Organic Synthesis also emphasizes environmentally-friendly methods for nitration, the importance of aliphatic nitro compounds, and modern preparation of nitro compounds. Other topics discussed include: * Henry reaction * Asymmetric Michael addition * Alkylation, acylation, halogenation, and related reactions of RNO2 * Substitution and elimination of NO2 and RNO2 The Nitro Group in Organic Synthesis is a useful resource for researchers and students in organic and medicinal chemistry.

Nitro chemistry plays an important role in organic synthesis to construct new frameworks. This is due to the diverse properties of the nitro group. The strong electron-withdrawing ability of the nitro group reduces the electron density of the scaffold, facilitating reactions with nucleophiles or electron transfer. In addition, the -hydrogen of the nitro group is highly acidic, giving a stable anion, which facilitates reactions with both electrophilic and nucleophilic reagents. In addition, the nitro group also serves as a good leaving group, which facilitates transformation to a wide variety of functional groups. Despite the substantial contributions of many researchers, nitro chemistry is still an exciting and challenging research area. This book brings together recent original research and review articles contributed by an international team of leading experts and pioneers in organic synthesis using nitro groups. It is sure to provide useful information and promising insights for researchers.

This multi-authored work reviews and evaluates the growing importance of the nitro group function. It describes the powerful influence of the nitro group on recent progress in organic synthesis and emphasizes recent developments in the chemistry of this group. The contributors consider the increasingly significant role of organic nitro chemistry in providing a source of new reagents and in offering selective transformations. They provide a detailed review of nitrogen pentoxide chemistry which stresses its usefulness as a nitrating agent for various classes of organic compounds. Researchers, students and teachers will benefit from the combined knowledge and expertise of the authors. The editor has worked and taught in many countries. He has published extensively on organic nitrogen compounds and has discovered new methods. Special feature: Contains the first complete survey of aliphatic fluoronitro chemistry.

Nitro Compounds provides information pertinent to the formation, mechanism, synthesis, and structure of nitro compounds. This book discusses the behavioral uniqueness of the nitro group in electric field. Organized into 50 chapters, this book begins with an overview of the amphoterism of HNO3 and its role in the reactions of HNO3 with organic substances. This text then examines the secondary nitroheptane obtained byvapor-phase nitration of n-heptane with nitrogen dioxide. Other chapters consider the explosion hazard of gaseous mixtures in exothermic reactions of oxidation and nitration. This book discusses as well the method used for the investigation of nitration of phenosulphonic acids. The final chapter deals with the relationship between the structure of nitrofuranoic compounds and the fungicidal, bactericidal, and herbicidal activity. This book is a valuable resource for chemists and organic chemists. Chemical researchers who are interested in the mechanism and synthesis of nitro compounds will also find this book useful.

Discover a comprehensive exploration of recent progress in the preparation of nitroalkanes from two leading voices in the field Nitroalkanes: Synthesis, Reactivity, and Applications delivers a thorough summary of the importance of nitroalkanes in organic synthesis. The book covers their preparation, transformation into other functional groups, like carbonyls and amines, and their use in the formation of single carbon-carbon or double carbon-carbon bonds. The distinguished authors have included chapters on acyclic and cyclic alpha-nitro ketones as well as the synthesis of cyclopropanes and spiro ketals. The book provides treatments of the application of nitroalkanes for the synthesis of important heterocycles, poly-functionalized structures, natural products, and compounds of biological and pharmaceutical interest. A one-stop resource in a topic that hasn???t been fully addressed by any other book in decades, this book covers the most important synthetic routes toward nitroalkanes. Readers will also benefit from the inclusion of: A thorough introduction to the synthesis of nitroalkanes, as well as the transformation of the nitro group into other functionalities An exploration of the formation of C-C single bonds, C=C double bonds, and the breaking of C3C bonds from cyclic alpha-nitro ketones Discussions of acyclic alpha-nitro ketones, nitroalkanes as precursors of cyclopropanes, and the synthesis of spiro ketals An examination of the preparation and synthetic applications of 1,3-Dinitroalkanes Perfect for organic chemists, natural products chemists, and catalytic chemists, Nitroalkanes: Synthesis, Reactivity, and Applications will also earn a place in the libraries of medicinal chemists seeking a one-stop resource for the most recent developments in the preparation of nitroalkanes, their functionalization, and their applications.

Nitroalkenes reveals the great significance to theoretical and synthetic chemistry of this class of compounds. Over recent years the applications of nitroalkenes have expanded rapidly from established areas, such as rocket propulsion and explosives, into biotechnology, perhaps the science of the 1990s. The high reactivity of nitroalkenes makes them particularly suitable for the synthesis of biologically active compounds such as alkaloids, antibiotics, prostaglandins and biocides, etc. Nitroalkenes is a unique and up-to-date analysis written for all chemists working in organic synthesis and chemical technology. The fascinating versatility of these compounds makes this book particularly relevant to researchers in the pharmaceutical, aerospace and explosives industries.