Synthesis And Biosynthesis Of Porphyrins And Iron Porphyrins

The Porphyrin Handbook, Volume 12: The Iron and Cobalt Pigments: Biosynthesis, Structure, and Degradation provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book presents the biochemical and clinical aspects of genetically transmitted or drug-induced diseases associated with errors in heme metabolism. Organized into eight chapters, this volume begins with an overview of the comparison of regulatory principles in animal and plant tetrapyrrole biosynthesis. This text then examines the biology and medical implications of porphyrin systems. Other chapters consider the transformation of hemes into bile pigments, the organic synthesis of bilins, and the pathways of degradation of chlorophyll in senescent plants. This book discusses as well the biosynthesis of porphyrins, vitamin B12, and chlorophylls. The final chapter deals with genome sequencing projects that provide sources of genes encoding the enzymes needed for the synthesis of the intermediates. This book is a valuable resource for research scientists, engineers, and clinicians.

The Porphyrin Handbook, Volume 13: Chlorophylls and Bilins: Biosynthesis, Synthesis, and Degradation provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into eight chapters, this volume begins with an overview of magnesium chelatase as a complex enzyme involved in the biosynthesis of chlorophyll and bacteriochlorophyll. This text then provides an accurate historical review of the two enzymes involved in photosynthetic pigment production. Other chapters consider the processes that take place in darkness in all plants including angiosperms as the early steps of chlorophyll biosynthesis. This book discusses as well the reactivity and structures of the known chlorophyll catabolites from vascular plants, synthetic sources, and microorganisms. The final chapter deals with the methodologies used for the synthesis of bile pigments. This book is a valuable resource for research scientists, engineers, and clinicians.

The Porphyrins, Volume VI: Biochemistry, Part A deals with the biochemistry of porphyrins, their precursors, catabolic derivatives, and related compounds. The book covers the biosynthesis of porphyrins and chlorophylls; the formation and metabolism of bile pigments in animals and plants; as well as the synthesis, characterization, and chemistry of the bile pigments and their derivatives. An account of the historical and clinical aspects of porphyrins and bile pigments is also given. This volume is organized into 12 chapters and begins with an overview of protoporphyrins and their metabolic intermediates, paying particular attention to their synthesis and biosynthesis. The discussion then shifts to the biosynthesis of porphyrins and chlorophylls; the in vivo formation and metabolism of bile pigments such as biliverdin and bilirubin; and yellow, green, and blue bile pigments. The reader is then introduced to bile pigments of plants including phytochrome and phycobiliproteins; the general structures and nomenclature of bile pigment derivatives; and the Stokvis reaction. The book also considers the clinical chemistry of porphyrins, and then concludes with a chapter on milestones in the history of bile pigments. This book will be of value to inorganic, organic, physical, and biochemists interested in the biochemistry of porphyrins.

FUNDAMENTALS OF PORPHYRIN CHEMISTRY An indispensable and concise overview of the chemistry of porphyrins and related molecules In Fundamentals of Porphyrin Chemistry: A 21st Century Approach, a team of distinguished researchers delivers a compact and accessible introduction to the broad field of porphyrin chemistry. It discusses the basics of porphyrin synthesis and structure, as well as that of related molecules, and the current and future roles that porphyrins play in chemical transformations, materials design and synthesis, energy capture and transduction, human health, and the environment. This edited volume is a self-contained tutorial on concepts of critical importance to porphyrin chemistry and serves as the foundation for discussions about the applications of porphyrin-related compounds found in the second volume. This book contains: A thorough introduction to porphyrins, including their structure, nomenclature, naturally occurring porphyrins, synthetic porphyrins, and common families of porphyrin-related compounds Comprehensive explorations of chemical porphyrin synthesis, including how to synthesize porphyrins from simple, symmetric, and advanced ABCD-substituted porphyrins Practical discussions of the physical characteristics of porphyrins, including their structural features, electronic structure, spectroscopy, magnetism, electrochemistry, and electron transfer processes Perfect for experienced academic researchers in the field of porphyrin chemistry seeking a quick reference, Fundamentals of Porphyrin Chemistry: A 21st Century Approach is also an indispensable resource for researchers new to the field who need an overview directing them to literature in more focused areas.

The Porphyrin Handbook, Volume 14: Medical Aspects of Porphyrins provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into 12 chapters, this volume begins with an overview of the underlying diagnostic features, mechanisms, and available treatments of erythropoietic disorders due to defective heme biosynthesis. This text then examines the physiopathology of acute intermittent porphyria, which is transmitted as autosomal dominant disorders with incomplete penetrance. Other chapters consider the main characteristics of congenital erythropoietic porphyria, which includes an increased synthesis, accumulation, ad excretion of porphyrins. This book discusses as well the biochemistry, pathophysiology, and clinical features of variegate porphyria in the light of several essential advances in the understanding, management, and diagnosis of variegate porphyria. The final chapter deals with the legal use of herbal and complementary medicines. This book is a valuable resource for research scientists, engineers, and clinicians.

The Porphyrins, Volume I: Structure and Synthesis, Part Ais the first in a series of seven volumes and covers topics like nomenclature, purification, and structural determination of porphyrins, metalloporphyrins, and other related compounds. This volume serves to be a critical review of the topics covered and presents a complete and comprehensible discussion on the chemistry and biochemistry of porphyrins. The chapters in the text tackle the history and geochemistry of porphyrins and related systems. Also covered and discussed in the chapters is the synthesis of porphyrins from mono-, di-, and tetrapyrrolic intermediates. The isolation and modification of porphyrins from natural sources are also discussed. Other related compounds are also included, such as metallo-, aza-, and N-methylporphyrins, and their synthesis and properties. This book is a good introduction and reference for students studying in the fields of chemistry and biochemistry.

The Porphyrin Handbook, Volume 14: Medical Aspects of Porphyrins provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into 12 chapters, this volume begins with an overview of the underlying diagnostic features, mechanisms, and available treatments of erythropoietic disorders due to defective heme biosynthesis. This text then examines the physiopathology of acute intermittent porphyria, which is transmitted as autosomal dominant disorders with incomplete penetrance. Other chapters consider the main characteristics of congenital erythropoietic porphyria, which includes an increased synthesis, accumulation, ad excretion of porphyrins. This book discusses as well the biochemistry, pathophysiology, and clinical features of variegate porphyria in the light of several essential advances in the understanding, management, and diagnosis of variegate porphyria. The final chapter deals with the legal use of herbal and complementary medicines. This book is a valuable resource for research scientists, engineers, and clinicians.

Scientists in such fields as mathematics, physics, chemistry, biochemistry, biology, and medicine are currently involved in investigations of porphyrins and their numerous analogues and derivatives. Porphyrins are being used as platforms for the study of theoretical principles, as catalysts, as drugs, as electronic devices, and as spectroscopic probes in biology and medicine. The need for an up-to-date and authoritative treatise on the porphyrin system has met with universal acclaim amongst scientists and investigators.