Superfusion

Now in paperback, Zachary Karabell argues that the intertwined economic relationship between China and the U.S. will affect our long-term prosperity more than any other contemporary issue. As the world continues the slow work of repairing the damage of the financial crisis, it is crucial that the U.S. understands that it cannot go it alone. Its mutuality with China is permanent, essential, and defining. Zachary Karabell’s brilliant book lays out this complex and important economic story. “Karabell excels at weaving in glitzy tales of the brave new China against the larger backdrop of the Middle Kingdom’s forceful but cautious economic liberalization and the often tortuous, frequently saber-rattling politics of U.S.-China relations….A provocative argument.” —Los Angeles Times “The question at the heart of Superfusion is a pressing one: What will happen next? Mr. Karabell says that the U.S. must turn its thinking away from the military and security challenges of the twentieth century and focus more on the economic challenges of the twenty-first.” —The Wall Street Journal “A compelling brief on the unlikely convergence of the U.S. and Chinese economies….Essential reading for anyone curious about the increasing economic integration and interdependence between China and America, the public opposition in both nations, and the implication for the U.S. as it faces competition from a nation it cannot coerce.” —Publishers Weekly (starred review)

A major advance in the biological sciences in the past decade has been the biochemical identification of cell membrane receptors. The existence of re ceptor substances on the surface of cells that recognize and bind to extracellular molecules was proposed at the beginning of the century by the pharmacologist and immunologist Paul Ehrlich and the physiologist J. N. Langley. Since then, receptors have been found to play an important role in numerous physiological and pathological processes. Over the years many attempts have been made to physically isolate and chemically characterize receptors, but because of the receptors' extremely low concentration and membrane localization, these ef forts have met with limited success. Yet, despite the failure to characterize receptor substances, the concept of the presence of such molecules has had considerable heuristic value. Using pharmacological, physiological, and im munologic approaches, researchers have identified several specific receptors, e. g. , a-and ~-adrenergic, nicotinic and muscarinic cholinergic, and histami nergic. With the characterization of various types of receptors on cell mem branes, many drugs were developed that proved to be experimentally and ther apeutically useful. It was only in the early 1970s that methods for the specific measurement, chemical characterization, and physical isolation of cell membrane receptors were developed. These advances were made possible by the availability of ligands with high specific radioactivity that retained their biological activity and of experimental procedures that differentiated between specific and non specific binding of ligands.

The proceedings of the 1987 IUPHAR symposium held in Sydney, Australia are fully documented. Over 100 scientists from 16 countries attended the three-day conference, during which time 68 multi-disciplinary presentations concerning dopamine systems and their regulation were made.

Advances in Physiological Sciences, Volume 7: Cardiovascular Physiology: Microcirculation and Capillary Exchange is a collection of papers that tackles the advances in the understanding of microcirculation and capillary exchange. The text first details the coordination of microcirculatory function with oxygen demand in skeletal muscle, and then proceeds to discussing the role of intravascular pressure in the regulation of the microcirculation. Next, the selection covers the circulatory actions of prostacyclin and thromboxane, along with the routes of transcapillary transport. The last two parts of the text deal with the lymphatic system and blood-brain barrier. The book will be of great interest to health professionals, particularly cardiologists and cardiovascular surgeons.

Proceedings of the International Symposium on Integrative and Cellular Aspects of Autonomic Functions Held in Bad Nauheim (Germany) on 29-30 July 1993.

During the period 1981 ? 1990, important areas of research being recognized were visual information processing, monoclonal antibodies, pharmacology, molecular biology and transplantation. The laureates according to the specific year are: (1981) R W SPERRY ? for his discoveries concerning the functional specialization of the cerebral hemispheres; D H HUBEL & T N WIESEL ? for their discoveries concerning information processing in the visual system; (1982) S K BERGSTR™M, B I SAMUELSSON & J R VANE ? for their discoveries concerning prostaglandins and related biologically active substances; (1983) B McCLINTOCK ? for her discovery of mobile genetic elements; (1984) N K JERNE, G J F K™HLER & C MILSTEIN ? for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies; (1985) M S BROWN & J L GOLDSTEIN ? for their discoveries concerning the regulation of cholesterol metabolism; (1986) S COHEN & R LEVI-MONTALCINI ? for their discoveries of growth factors; (1987) S TONEGAWA ? for his discovery of the genetic principle for generation of antibody diversity; (1988) J W BLACK, G B ELION & G H HITCHINGS ? for their discoveries of important principles for drug treatment; (1989) J M BISHOP & H E VARMUS ? for their discovery of the cellular origin of retroviral oncogenes; (1990) J E MURRAY & E D THOMAS ? for their discoveries concerning organ and cell transplantation in the treatment of human disease.

Since its discovery 50 years ago, brain dopamine has been implicated in the control of movement and cognition, and is concerned with diverse brain diseases such as Parkinson's disease, schizophrenia and drug addiction. This book is an illustrated biography of the dopamine molecule, from its synthesis in the brain to its signalling mechanisms and ultimately to its metabolic breakdown. Using colour illustrations of positron emission tomography (PET) scans, each chapter presents a specific stage in the biochemical pathway for dopamine. Writing for researchers and graduate students, Paul Cumming presents a compilation of all that has been learned about dopamine through molecular imaging, a technology which allows the measurement of formerly invisible processes in the living brain. He reviews current technical controversies in the interpretation of dopamine imaging, and presents key results illuminating brain dopamine in illness and health.

This book, which originated in the presentations of a symposium sponsored by the Universidad Nacional Autonoma de Mexico, held in Mexico City on April 14-16, 1980, represents an attempt to analyze some of the most relevant aspects of synaptic transmission. This topic was chosen on the strong belief that the progress of the neurosciences depends to a great extent on the understanding of the basic mechanisms of synaptic function. Rather than selecting only a specific approach or speciality, the book intends to cover this field in a multi disciplinary way. This means that neurochemical, neurophysiological and morphological studies are mingled throughout the book, which hopefully will help the reader to integrate the different faces of the same problem. Across the book the presynaptic component of synaptic transmission and its regulation is stressed much more than the postsynaptic phenomena. Although this might be a limitation, it has the advantage of increasing the focus of the book on a series of events which are gaining importance and interest every day.