Statistical Principles In Experimental Design

A revision of this classic statistics text for first-year graduate students in psychology, education and related social sciences. The two new authors are former students of Winer's. They have updated, rewritten and reorganized the text to fit the course as it is now taught.

This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's excellent Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication.

In all the experimental sciences, good design of experiments is crucial to the success of research. Well-planned experiments can provide a great deal of information efficiently and can be used to test several hypotheses simultaneously. This book is about the statistical principles of good experimental design and is intended for all applied statisticians and practising scientists engaged in the design, implementation and analysis of experiments. Professor Mead has written the book with the emphasis on the logical principles of statistical design and employs a minimum of mathematics. Throughout he assumes that the large-scale analysis of data will be performed by computers and he is thus able to devote more attention to discussions of how all of the available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from medicine, agriculture, industry and other disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design of experiments can make to a scientific project.

"In this Second Edition of Design of Experiments: Statistical Principles of Research Design and Analysis, Bob Kuehl continues to treat research design as a very practical subject. He emphasizes the importance of developing a treatment design based on research hypothesis as an initial step and then developing an experimental or observational study design that facilitates efficient data collection. With the book's wide array of examples from actual studies from many scientific and technological fields, Kuehl constantly reinforces the research design process."--Back cover.

This open access textbook provides the background needed to correctly use, interpret and understand statistics and statistical data in diverse settings. Part I makes key concepts in statistics readily clear. Parts I and II give an overview of the most common tests (t-test, ANOVA, correlations) and work out their statistical principles. Part III provides insight into meta-statistics (statistics of statistics) and demonstrates why experiments often do not replicate. Finally, the textbook shows how complex statistics can be avoided by using clever experimental design. Both non-scientists and students in Biology, Biomedicine and Engineering will benefit from the book by learning the statistical basis of scientific claims and by discovering ways to evaluate the quality of scientific reports in academic journals and news outlets.

This textbook consists of three parts: basic concepts of statistics, advanced statistical methods, and design and analysis for medical research. Each chapter begins with challenging medical problems and related statistical methods and theories; to make the statistical ideas more easily understood, there is a section of “computer experiments” in each chapter where some basic statistical phenomena and related concepts are revealed. The statistical software SAS is used to carry out related statistical calculations.The aim of this book is to make medical students and researchers grasp easily the most useful tools of statistics for their medical research. It is done through various applications to a great number of medical problems, interesting demonstration of well-designed computer experiments and detailed explanation of statistical thinking.

This text provides an overall research design strategy by emphasizing how research hypotheses relate to treatment design. The author provides as realistic a setting as possible for conducting an actual research project. Examples, often based on actual research studies, describe the research venue and establish a specific problem; then the corresponding research hypothesis is identified with a treatment design that addresses it. The examples provide practical pointers relating the treatment design to the experiment design.

Fundamental Statistical Principles for Neurobiologists introduces readers to basic experimental design and statistical thinking in a comprehensive, relevant manner. This book is an introductory statistics book that covers fundamental principles written by a neuroscientist who understands the plight of the neuroscience graduate student and the senior investigator. It summarizes the fundamental concepts associated with statistical analysis that are useful for the neuroscientist, and provides understanding of a particular test in language that is more understandable to this specific audience, with the overall purpose of explaining which statistical technique should be used in which situation. Different types of data are discussed such as how to formulate a research hypothesis, the primary types of statistical errors and statistical power, followed by how to actually graph data and what kinds of mistakes to avoid. Chapters discuss variance, standard deviation, standard error, mean, confidence intervals, correlation, regression, parametric vs. nonparametric statistical tests, ANOVA, and post hoc analyses. Finally, there is a discussion on how to deal with data points that appear to be "outliers" and what to do when there is missing data, an issue that has not sufficiently been covered in literature. An introductory guide to statistics aimed specifically at the neuroscience audience Contains numerous examples with actual data that is used in the analysis Gives the investigators a starting pointing for evaluating data in easy-to-understand language Explains in detail many different statistical tests commonly used by neuroscientists

"Free CD contains several real and artificial data sets used in the book in SPSS, SYSTAT, and ASCII formats"--Cover

Statistical design is one of the fundamentals of our subject, being at the core of the growth of statistics during the previous century. In this book the basic theoretical underpinnings are covered. It describes the principles that drive good designs and good statistics. Design played a key role in agricultural statistics and set down principles of good practice, principles that still apply today. Statistical design is all about understanding where the variance comes from, and making sure that is where the replication is. Indeed, it is probably correct to say that these principles are even more important today.