Renal Biopsy Interpretation

This handbook provides a short, clear, useful and interesting guide to the findings in renal biopsy specimens. Essential information needed for an understanding of renal disorders is given simply and concisely. The focus is on common conditions. The book is intended to be of practical help primarily to pathologists and trainee pathologists who look at renal biopsy specimens, but also to others who have contact with anyone with renal disorders. The handbook includes more than 240 color illustrations. Other features include practical tips on the differentiation between possible diagnoses and information about eponyms.

An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

This book is a practical guide to renal biopsy interpretation for trainees in pathology and nephrology. Beginning with an introduction to biopsy, indications and histopathologic evaluation, the following chapters cover biopsy and subsequent diagnosis of different renal diseases. Presented in bullet point format for ease of learning, each chapter begins with an abstract summarising the key points of the topic, and concludes with detailed references for further reading. The text is further enhanced by pathologic photographs and figures to assist understanding. Key points Practical guide to renal biopsy interpretation for trainees Presented in bullet point format for ease of learning Each chapter includes a summary abstract and references for further reading Features pathologic photographs and figures to assist understanding

Vor die Therapie setzten die Gotter die Diagnose. Otto NiigeJi Renal biopsy has decisively enriched renal diagnostics. Kidney diseases may be monitored during their entire course, and new techniques - such as immunofluorescence and electron microscopy - may be systematically applied, resulting in novel insights into the morphogenesis, pathogenesis, and etiology of kidney lesions. These insights, in turn, have served as new starting points, in the spirit of the quotation above, for the institution of causal therapy by the clinician. This work presents our findings based on 20 years of experience in evaluating renal biopsies. As of the end of 1974, our computer-supported, systematic clinical, morphologic, and follow-up evaluation of case material consisted of over 2000 biopsies, including 679 examined by electron microscopy and 400 by immunofluorescence microscopy. The subsequent 500 biopsies (400 studied by electron microscopy and 300 by immunofluorescence) were con sidered qualitatively only. In order to enhance qualitative findings with quantitative data, it was necessary to devise new methods for quantifying electron-microscopic findings. Additionally, we attempted to correlate cyto logic and immunofluorescent observations to integrate the isolated findings of electron microscopy into a vital cytologic pattern of reactions. We also attempted to evaluate the almost overwhelming flood of publications, especially those appearing within the last 10 years. The idea for this book was conceived a decade ago. At that time, however, our own experience in renal biopsy diagnostics seemed insufficient to sup port such a major undertaking.

The world's leading renal pathologists clearly and systematically identify The full spectrum of morphologic patterns encountered during renal biopsy interpretation. Strongly correlated with the clinical aspects of diagnosis, this hands-on text comprehensively reviews and interstitium, and vessels. It is an authoritative reference for the renal pathology newcomer and an essential reference for the experienced pathologist.

This practical volume in the Biopsy Interpretation Series is your guide to effective diagnostic biopsy of the kidney and adrenal glands. Presented in a reader-friendly format, the text includes abundant photomicrographs of actual biopsy samples as well as correlative photos of surgical specimens and ancillary immunohistochemical studies. Each organ is addressed in a separate section that includes an introduction to biopsy techniques and an overview of normal histology. Positive diagnoses for renal lesions are described by tumor type. Adrenal lesions are grouped by primary and metastatic tumors, reflecting the main diagnostic considerations at the adrenal site. Uniquely detailed focus addresses the specific techniques and interpretive features of renal and adrenal biopsy. Timely content addresses the use of renal biopsy in minimally invasive therapeutic techniques as well as its role in active surveillance of renal masses. The latest ISUP classifications reflect newly described renal tumors discussed at the March 2012 USCAP annual meeting. Clinical implications of each diagnosis are highlighted throughout the text to guide therapeutic decision-making.

1 This book is meant to be a practical guide to interpretation of renal biopsy specimens. Two things follow. First, the book has much less text than most on renal pathology, because only a little is said about pathogenesis and other matters not directly relevant to interpretation, nor are diseases mentioned that are not investigated by biopsy such as many developmental disorders, nor is there much on rare con ditions. Large and comprehensive textbooks can be consulted where necessary. The second thing is that this book has a different approach from standard texts in pathology. These consider each disease separately as identified, known, defined entities. This is excellent if a pathologist knows what to call the disease in a particular specimen and wishes to confirm the diagnosis or find out more about it, but is little use if the pathologist has no idea about the diagnosis. Most pathologists have experience of the search through many descriptions of diseases in textbooks to try to find the name that seems the most appropriate for the abnormalities in a specimen. This book should be seen as a guide into the standard texts that may be used as references for further information once a diagnosis has been made. This book tries to help the pathologist by the use of two rules, common things are common and diseases present in characteristic clinical ways. The book is arranged by clinical presentation rather than by diseases and concentrates on common conditions.

This Handbook serves as a convenient, state-of-the-art and comprehensive resource on the pathogenesis, diagnosis, and treatment of glomerular diseases. Clinical approaches, modalities and challenges are provided, along with new developments since the publication of Kidney Disease Improving Global Outcomes (KDIGO): Glomerulonephritis. Chapters dedicated to glomerular diseases mirror the current classification schemes used by Nephrologists and Pathologists and will include definition and natural history, epidemiology, clinical manifestations, pathology, diagnosis, differential diagnosis, treatment (algorithms when appropriate), prognosis and future prospects and current direction of research. Contributing authors consist of internationally renowned glomerulonephritis experts, renal pathologists and clinical nephrologists who are engaged in the management of glomerular diseases in clinical pediatric and internal medicine practices. Glomerulonephritis fills a considerable knowledge gap for general nephrologists, providers involved with the care of patients with glomerular diseases, and researchers. It should also be of value to medical students, interns, residents and fellows, as well as all clinicians engaged in medical education.

There is no dearth of high-quality books on renal biopsy and pathology in the market. These are either single author or multi-author books, written by world authorities in their respective areas, mostly from the developed world. The vast scholarly potential of authors in the developing countries remains underutilized. Most of the books share the classical monotony of the topics or subjects covered in the book. The current book is a unique adventure in that it bears a truly international outlook and incorporates a variety of topics, which make the book a very interesting project. The authors of the present book hail not only from the developed world, but also many developing countries. The authors belong not only to US but also to Europe as well as to Pakistan and Japan. The scientific content of the book is equally varied, spanning the spectrum of technical issues of biopsy procurement, to pathological examination, to individual disease entities, renal graft pathology, pathophysiology of renal disorders, to practice guidelines.

Diagnostic Atlas of Renal Pathology, by Agnes B. Fogo, MD and Michael Kashgarian, MD, delivers practical, highly visual guidance for effectively and accurately diagnosing a wide range of pathologic entities. More than 700 high-quality illustrations help you to recognize the pathologic features and clinical manifestations of both common and rare renal disorders and to formulate confident and accurate diagnoses. Thoroughly updated throughout, this companion to Brenner & Rector’s The Kidney, 9th Edition provides the newest information regarding categorizing and classification of diseases and describes how this relates to the various morphological lesions illustrated and their clinical significance. See more than 700 high quality representative images of light, immunofluorescence, and electron microscopy for each diagnostic entity with correlations to clinical presentation and pathogenesis. Easily locate in-depth information on any disease's clinical course and treatment by cross-referring companion text, Brenner & Rector’s The Kidney. Grasp key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information through focused, detailed discussions. Make accurate, complete reports by fully understanding clinical correlations. Get an in-depth examination of pathophysiology, clinical presentations, and comprehensive references Keep current with the latest knowledge and evidence-based practices. Comprehensive updates throughout include a brand-new chapter on "Approaches to Chronic Kidney Disease" that includes coverage of Chronic Kidney Disease; Age-Related Sclerosis; Glomerular vs. Tubulointerstitial vs. Vascular Disease; and the differential diagnostic approach to Segmental Glomerulosclerosis lesions. Extensive updates to all previous chapters include new classifications of various diseases such as igA nephropathy, diabetic nephropathy, crescentic GN, and renal transplant rejection. Stay well informed about hot topics including acute phosphate nephropathy; new concepts in the pathogenesis of thrombotic microangiopathies and eclampsia; and new information relative to etiology and pathogenesis of podocytopathies. Quickly access the information you need thanks to a user-friendly format, tables and sidebars with key points and differential diagnoses, and chapters that include concise, templated discussions regarding the etiology and pathogenesis of the disorder.