Regulation Of The Contractile Cycle In Smooth Muscle
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Author | : Takeshi Nakano |
Publisher | : Springer Science & Business Media |
Total Pages | : 240 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 4431658807 |
Download Regulation of the Contractile Cycle in Smooth Muscle Book in PDF, Epub and Kindle
At the Mie International Symposium held in Japan in April 1994, leading scientists reviewed recent advances in the understanding of the contractile mechanism in smooth muscle. The present volume collects the papers presented at the symposium, summarizing the latest advances in smooth muscle function and emphasizing important components of the contraction-relaxation cycle. Topics include a discussion of the smooth muscle cell membrane, with emphasis on its ion channels; the regulation of cytosolic Ca2+ levels and the relationship to force in smooth muscle; aspects of the two key regulatory enzymes involved with myosin phosphorylation-dephosphorylation; the molecular basis for pharmacomechanical coupling in smooth muscle; developments in the basic contractile mechanisms involving the crossbridge cycle of tonic and phasic muscle; the role of myosin light chains; and many others. The approach is broad and presents contemporary opinions in pharmacology, physiology, and biochemistry as they relate to smooth muscle function. The book will appeal not only to those working in these disciplines, but to vascular clinicians, obstetric-gynecological physicians, and gastroenterologists as well.
Author | : Robert S. Moreland |
Publisher | : Springer Science & Business Media |
Total Pages | : 547 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 146846003X |
Download Regulation of Smooth Muscle Contraction Book in PDF, Epub and Kindle
Sixth Annual Graduate Hospital Research Symposium REGULATION OF SMOOTH MUSCLE PROGRESS IN SOLVING THE PUZZLE Every so often a scientific conference comes at a time when everyone has new and exciting information, when old "dogmas" do not seem to be as well established, and when speakers and participants alike are ready to challenge interpretations of old and new experimental data. This was such a conference. What turns on a smooth muscle cell? The precise answer to this question has eluded scientists for much longer than I have been involved in the field. We know that an increase in cytosolic calcium is necessary and we know that phosphorylation of the 20 kDa myosin light chain is an important step in the process. We do not know if other processes are necessary for the initiation and lor maintenance of a smooth muscle contraction nor do we know if other processes modulate the regulation of contraction. The goal of the symposium on which this volume is based was to explore the most current hypotheses for the answers to these questions. I believe that after reading the chapters included in this volume, you will agree that this goal was achieved. The importance of calcium and calmodulin dependent myosin light chain phosphoryla tion in the regulation of smooth muscle contraction was reinforced by many presentations. However, the status of myosin light chain phosphorylation as a simple calcium dependent switch came under serious suspicion.
Author | : Michael Barany |
Publisher | : Elsevier |
Total Pages | : 455 |
Release | : 1996-01-04 |
Genre | : Science |
ISBN | : 0080527892 |
Download Biochemistry of Smooth Muscle Contraction Book in PDF, Epub and Kindle
This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
Author | : Robert Fitridge |
Publisher | : University of Adelaide Press |
Total Pages | : 589 |
Release | : 2011 |
Genre | : Medical |
ISBN | : 1922064009 |
Download Mechanisms of Vascular Disease Book in PDF, Epub and Kindle
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author | : Robert S Moreland |
Publisher | : |
Total Pages | : 576 |
Release | : 1992-01-31 |
Genre | : |
ISBN | : 9781468460049 |
Download Regulation of Smooth Muscle Contraction Book in PDF, Epub and Kindle
Author | : International Union of Physiological Sciences. Satellite Conference on Smooth Muscle Contraction |
Publisher | : New York : Liss |
Total Pages | : 544 |
Release | : 1987 |
Genre | : Nature |
ISBN | : |
Download Regulation and Contraction of Smooth Muscle Book in PDF, Epub and Kindle
Author | : Sushil K. Sarna |
Publisher | : Biota Publishing |
Total Pages | : 159 |
Release | : 2010-11-01 |
Genre | : Medical |
ISBN | : 1615041516 |
Download Colonic Motility Book in PDF, Epub and Kindle
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 1994 |
Genre | : |
ISBN | : |
Download Mie International Symposium Book in PDF, Epub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 406 |
Release | : 2018-01-05 |
Genre | : Medical |
ISBN | : 0128121521 |
Download Vascular Pharmacology: Cytoskeleton and Extracellular Matrix Book in PDF, Epub and Kindle
Vascular Pharmacology: Cytoskeleton and Extracellular Matrix, Volume 81, contains the latest information on the vascular cytoskeleton and extracellular matrix that is presented with helpful illustrations and supporting references by prominent scientists and highly-recognized experts in the vascular field. Topics of interest in this new release include Pharmacology of the Vascular Cytoskeleton and Extracellular Matrix, The Dynamic Actin Cytoskeleton in Smooth Muscle, The Role of the Actin Cytoskeleton in the Regulation of Vascular Inflammation, The Smoothelin Family of Proteins and the Smooth Muscle Cell Contractile Apparatus, Smooth Muscle Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF, and more. Presents a must-read book on the vascular cytoskeleton and extracellular matrix Contains up-to-date information on the structure, function and development of the vascular cell cytoskeleton Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the fields of the vascular cytoskeleton, extracellular matrix, mechanotransduction and vascular remodeling
Author | : Lindsay Biga |
Publisher | : |
Total Pages | : |
Release | : 2019-09-26 |
Genre | : |
ISBN | : 9781955101158 |
Download Anatomy & Physiology Book in PDF, Epub and Kindle
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