Regional Workshop To Operationalize The Global Guidance Framework For The Responsible Use Of The Life Sciences In The Who African Region

This report summarizes the discussions of a two-day technical workshop on the operationalization of the global guidance framework in the WHO African Region and the discussions of the partners’ meeting, held in Nairobi, Kenya, on 24-25 January 2023. The workshop, which was organized by the WHO Science Division, in collaboration with the WHO Regional Office for Africa and the Africa Centres for Disease Control and Prevention (Africa CDC), was aimed at discussing the framework and other related existing regional initiatives; facilitating the sharing of knowledge and experience of countries on the challenges and needs in mitigating biorisks and governing dual-use research; strengthening collaboration among multiple and multidisciplinary stakeholders within the WHO African Region; identifying the needs for additional toolkits or regional guidance; and recommending concrete actions for the roll-out of a national implementation of the framework.

The framework aims to provide global perspectives on principles, tools and mechanisms to support Member States and relevant stakeholders to mitigate and prevent biorisks and govern dual-use research. The framework adopts the One health approach and focuses on the role that responsible life sciences research can play in preventing and mitigating risks caused by accidents, inadvertent or deliberate misuse with the intention to cause harm to humans, nonhuman animals, plants and agriculture, and the environment. The framework is primarily intended for those who have responsibilities in the governance of biorisks, such as policy makers and regulators in charge of developing national policies to harness the potential benefits of the life sciences while constraining their risks. The framework is also directed towards scientists and research institutions, educators, trainers, project management staff, funding bodies, publishers, editors, the private sector and all relevant stakeholders that are part of the research life cycle. The governance of biorisks is an issue that should engage all countries, although countries will have different contexts, needs and starting points. Mitigating these risks will require individual and collective actions among different stakeholders and disciplines. Mitigating biorisks and governing dual-use research is a shared responsibility.

The Technical Advisory Group on the Responsible Use of the Life Sciences and Dual-Use Research (TAG-RULS DUR) was established in November 2023 to provide independent advice to WHO including on technical and strategic advice relevant to the monitoring and mitigation of biorisks, advances in the life sciences and related technologies, the governance of dual-use research and the responsible use of the life sciences. On 24 January 2024, eighteen members of the TAG-RULS DUR virtually met to introduce TAG-RULS DUR members; to discuss current and future activities related to the responsible use of the life sciences and dual-use research; and to share the members’ perspectives and visions on the work ahead.

The WHO Science Division organized a Consultative Meeting on a Global Guidance Framework to Harness the Responsible Use of the Life Sciences, on 11 March 2021, bringing a broad range of stakeholders that included academia, scientists and researchers, publishers and editors, security actors, public health officers, policy makers, research donors, and representatives from regional and UN entities. The objectives of the meeting were to consult on the scope of the Global Guidance Framework and on the critical elements this framework should address. The outcomes of this consultation will contribute to inform the development of the Global Guidance Framework. The meeting consisted of presentations and plenary discussions guided by a series of key questions. Overall, participants recommended to set up, at international level, a common terminology covering safe, secure and responsible research. Two major themes emerged during the discussions: the need for an overall risk management and a unified approach as well as the importance of awareness, education and training across the different stakeholder groups.

The purpose of this guidance is to inform Member States about the risks posed by accidents or the potential deliberate misuse of life sciences research and to propose measures to minimize these risks within the context of promoting and harnessing the power of the life sciences to improve health for all people. Although the issues addressed in this document can potentially interest a quite large audience, the proposed measures and the self-assessment questionnaire are of a public health nature. Health researchers, laboratory managers and research institutions are therefore the primary audience of this guidance.

Continuing advances in science and technology offer the promise of providing tools to meet global challenges in health, agriculture, the environment, and economic development; some of the benefits are already being realized. However, such advances have the potential to challenge the oversight systems for responsible conduct of life sciences research with dual use potential â€" research that may have beneficial applications but that also could be misused to cause harm. Between June 10 and 13, 2018, more than 70 participants from 30 different countries and 5 international organizations took part in an international workshop, The Governance of Dual Use Research in the Life Sciences: Advancing Global Consensus on Research Oversight, to promote global dialogue and increased common understandings of the essential elements of governance for such research. Hosted by the Croatian Academy of Sciences and Arts in Zagreb, Croatia, the workshop was a collaboration among the InterAcademy Partnership, the Croatian Academy, the Croatian Society for Biosafety and Biosecurity, and the U.S. National Academies of Sciences, Engineering, and Medicine. This publication summarizes the presentations and discussions from the workshop.

This publication is the first to focus on the health of the 738 million people living in the 46 countries of the WHO African Region. Drawing on a comprehensive range of the latest regional health statistics, the report discusses the key public health and development challenges facing the continent, as well looking in more detail at the issues of maternal and child health; infectious diseases including HIV/AIDS, tuberculosis and malaria; health problems that are usually associated with developed countries, such as diabetes and hypertension, and other noncommunicable conditions such as mental illness and injuries; and the environmental causes of ill-health including pollution and armed conflict. The report explores the treatment, diagnostic and preventive methods that work in Africa and highlights the public health success stories that can serve as models for others in the continent. It finds that stronger health systems are the key to solving Africa's health problems and these can only achieved by strengthening governments' stewardship role in health, building on the lessons learnt from successful health-care interventions, and through closer collaboration between all partners.

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