Quantitative Physiology

Quantitative Human Physiology: An Introduction, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects. Winner of a 2018 Textbook Excellence Award (College) (Texty) from the Textbook and Academic Authors Association Features a quantitative approach that includes physical and chemical principles Provides a more integrated approach from first principles, integrating anatomy, molecular biology, biochemistry and physiology Includes clinical applications relevant to the biomedical engineering student (TENS, cochlear implants, blood substitutes, etc.) Integrates labs and problem sets to provide opportunities for practice and assessment throughout the course NEW FOR THE SECOND EDITION Expansion of many sections to include relevant information Addition of many new figures and re-drawing of other figures to update understanding and clarify difficult areas Substantial updating of the text to reflect newer research results Addition of several new appendices including statistics, nomenclature of transport carriers, and structural biology of important items such as the neuromuscular junction and calcium release unit Addition of new problems within the problem sets Addition of commentary to power point presentations

Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics

NOTE: NO FURTHER DISCOUNT FOR THIS PRINT PRODUCT- OVERSTOCK SALE -- Significantly reduced list price Few human activities demand or deserve as much attention of the citizens of a nation as the array of man-made and natural "environmental" threats faced by the soldiers and other warriors defending the nation - those that pose the risk of disease, injury, combat wounds, and even death. This book is the Army's first detailing research in computational physiology models and highlighting pivotal research. It outlines the extent to which basic and applied biomedical scientists, clinicians, modelers, and others stribe to understand the extent of these threats, and provide intellectual and materiel options to mitigate these risks. This book summarizes major Army research efforts to quantify and model military relevant physiology. These chapters highlight the translation of this research into useful predictive tools. The tools are of importance to medical planners, materiel developers, commanders, and in many cases, every soldier. These chapters detail the experimental basis for many of the predictive tools that are currently in use. This book is written for military clinicians, and medical researchers who may be reasonably expected to explain some of the background, as well as those who will extend the research. Many people will find this book interesting because it details research on topics that affect everyone in everyday life, including how we sleep, eat, and exercise, as well as more specific topics such as the effects of caffeine on performance, risks associated with laser pointers, and even Army blast models that have influenced safety thresholds for car airbag deployments.

Thinking quantitatively about physiology is something many students find difficult. However, it is fundamentally important to a proper understanding of many of the concepts involved. In this enlarged second edition of his popular textbook, Richard Burton gives the reader the opportunity to develop a feel for values such as ion concentrations, lung and fluid volumes, blood pressures etc. through the use of calculations which require little more than simple arithmetic for their solution. Much guidance is given on how to avoid errors and the usefulness of approximation and 'back-of-envelope sums'. Energy metabolism, nerve and muscle, blood and the cardiovascular system, respiration, renal function, body fluids and acid-base balance are all covered, making this book essential reading for students (and teachers) of physiology everywhere, both those who shy away from numbers and those who revel in them.

Whether you are a bioengineer designing prosthetics, an aerospace scientist involved in life support, a kinesiologist training athletes, or an occupational physician prescribing an exercise regimen, you need the latest edition of Biomechanics and Exercise Physiology: Quantitative Modeling. Using numerous worked examples to demonstrate what and when

A STUDY OF PLANTS-CLIMATE AND THE IMPACTS OF CHANGE UPON VEGETATION.

This book provides an introduction to qualitative and quantitative aspects of human physiology. It examines biological and physiological processes and phenomena, including a selection of mathematical models, showing how physiological problems can be mathematically formulated and studied. It also illustrates how a wide range of engineering and physics topics, such as electronics, fluid dynamics, solid mechanics and control theory can be used to describe and understand physiological processes and systems. Throughout the text, there are introductions to measuring and quantifying physiological processes using both signaling and imaging technologies. This new edition includes updated material on pathophysiology, metabolism and the TCA cycle, as well as more advanced worked examples. This book describes the basic structure and models of cellular systems, the structure and function of the cardiovascular system, and the electrical and mechanical activity of the heart, and provides an overview of the structure and function of the respiratory and nervous systems. It also includes an introduction to the basic concepts and applications of reaction kinetics, pharmacokinetic modelling and tracer kinetics. It appeals to final year biomedical engineering undergraduates and graduates alike, as well as to practising engineers new to the fields of bioengineering or medical physics.

This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.