Photochemical Crosslinking Of Nucleic Acids With Psoralens As A Probe For The Genome Structure Of Prokaryotes And Eukaryotes

In one form or another psoralens have been in use dating back to biblical times for the treatment of depigmented patches of skin. However, it has only been in the past 40 years that the structure and function of psoralens have been elucidated. Although several volumes have been published on photobiology and photomedicine, no one volume has ever been devoted to the psoralen photobiology. In these two volumes we focus on the properties and uses of photoactivated psoralens.In these volumes the various aspects of psoralens are presented in a review of the field as it stands in mid 1986. In retrospect, we may find that this particular time was crucial in the development of new therapeutic modalities as many of the applications of modem molecular biology are beginning to impact on the practice of medicine.This book was written with two purposes in mind. First, to serve as an update (the last collective review of the field was in 1982). Second, it is hoped that newcomers to the fields of photobiology andphotomedicine both scientists and clinicians would find it a useful introduction.

In one form or another psoralens have been in use dating back to biblical times for the treatment of depigmented patches of skin. However, it has only been in the past 40 years that the structure and function of psoralens have been elucidated. Although several volumes have been published on photobiology and photomedicine, no one volume has ever been devoted to the psoralen photobiology. In these two volumes we focus on the properties and uses of photoactivated psoralens.In these volumes the various aspects of psoralens are presented in a review of the field as it stands in mid 1986. In retrospect, we may find that this particular time was crucial in the development of new therapeutic modalities as many of the applications of modem molecular biology are beginning to impact on the practice of medicine.This book was written with two purposes in mind. First, to serve as an update (the last collective review of the field was in 1982). Second, it is hoped that newcomers to the fields of photobiology andphotomedicine both scientists and clinicians would find it a useful introduction.

Includes entries for maps and atlases.

DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics. Explains basic DNA Structure and function clearly and simply Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure Highlights key experiments and ideas within boxed sections Illustrated with 150 diagrams and figures that convey structural and experimental concepts