Pharmacology In Space Medicine

“Space Pharmacology” is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights. It is a comprehensive review of the literature, addressing each area of pharmacokinetics and each major physiological system in turn. Every section begins with a topic overview, and is followed by a discussion of published data from spaceflight, and from ground experiments meant to model the spaceflight situation. Includes a discussion looking forward to the new medical challenges we are likely to face on longer duration exploration missions. This book is a snapshot of our current knowledge that also highlights areas of unknown.

The study of the specific effect of medications under laboratory experimental conditions (G loads, weightlessness, prolonged isolation, etc.) and possible emergency situations (change in environmental gases, radiation effects, upset in meal schedule, etc.) is a necessary stage in the preparation for long space missions. Two basic aspects of the general problems of space pharmacology are: (1) enhance body tolerance to extreme flight factors and (2) natural response to medications during the simulation of some space-flight stresses.

This handbook, directed at medical professionals and students who are involved in developing the space industry or are academicians doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation. As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players.

2009 life science book award from IAA.

Nicogossian, Arnauld E., Investigator, NASA Center: HQS; Huntoon, Carolyn Leach, Investigator, NASA Center: JSC; Pool, Sam L., Investigator, NASA Center: JSC.

Investigations in space have led to fundamental discoveries of the human body to the space environment. Gilles Clément has conducted extensive research in this field. This readable text presents the findings from the life science experiments conducted during and after space missions. About 1200 human space flights have been completed to date, including more than 500 astronauts from various countries, for a combined total presence in space of about 90 years. The first edition of this title was published in 2005 (written in 2003 – 2004), and new data is now available from crewmembers participating in long-duration flights on board the International Space Station (ISS). The number of astronauts who have spent six months in orbit has doubled since 2004. On board the ISS, the astronauts use newly developed pharmaceutical countermeasure for bone loss (such as biophosphonates) and state-of-the-art exercise resistive devices against muscle atrophy and cardiovascular deterioration. The ISS life support systems now use advanced closed-loop systems for meeting the needs of a 6-person crew, including recycling urine to water. Some of these new technologies have potential spin-offs for medical (i.e., sedentary life style, obesity) and environmental issues here on Earth. And finally, there are new space research opportunities with the Orion space vehicle that will soon replace the Space Shuttle, the Moon, and Mars space exploration program that is slowly but surely taking shape, and the space tourism sector that has become a reality. The focus on this edition is the ISS, Orion and planetary exploration, and space tourism. This edition also includes more than 20% new material, along with photographs, data, and video clips for Springer Extras!

Encompassing all occupants of aircraft and spacecraft—passengers and crew, military and civilian—Fundamentals of Aerospace Medicine, 5th Edition, addresses all medical and public health issues involved in this unique medical specialty. Comprehensive coverage includes everything from human physiology under flight conditions to the impact of the aviation industry on public health, from an increasingly mobile global populace to numerous clinical specialty considerations, including a variety of common diseases and risks emanating from the aerospace environment. This text is an invaluable reference for all students and practitioners who engage in aeromedical clinical practice, engineering, education, research, mission planning, population health, and operational support.

This supplemental issue of Aerospace Medicine and Biology, A Continuing Bibliography with Indexes (NASA/SP-1999-7011) lists reports, articles, and other documents recently announced in the NASA STI Database. In its subject coverage, Aerospace Medicine and Biology concentrates on the biological, physiological, psychological, and environmental effects to which humans are subjected during and following simulated or actual flight in the Earth's atmosphere or in interplanetary space. References describing similar effects on biological organisms of lower order are also included. Such related topics as sanitary problems, pharmacology, toxicology, safety and survival, life support systems, exobiology, and personnel factors receive appropriate attention. Applied research receives the most emphasis, but references to fundamental studies and theoretical principles related to experimental development also qualify for inclusion. Each entry in the publication consists of a standard bibliographic citation accompanied, in most cases, by an abstract.Langley Research CenterBIBLIOGRAPHIES; AEROSPACE MEDICINE; EXOBIOLOGY; BIOASTRONAUTICS; BIOLOGICAL EFFECTS; INDEXES (DOCUMENTATION); PSYCHOLOGICAL EFFECTS; PHARMACOLOGY; PHYSIOLOGICAL EFFECTS; AEROSPACE ENVIRONMENTS; LIFE SUPPORT SYSTEMS; MANNED SPACE FLIGHT...

This supplemental issue of Aerospace Medicine and Biology, A Continuing Bibliography with Indexes (NASA/SP-1999-7011) lists reports, articles, and other documents recently announced in the NASA STI Database. In its subject coverage, Aerospace Medicine and Biology concentrates on the biological, physiological, psychological, and environmental effects to which humans are subjected during and following simulated or actual flight in the Earth's atmosphere or in interplanetary space. References describing similar effects on biological organisms of lower order are also included. Such related topics as sanitary problems, pharmacology, toxicology, safety and survival, life support systems, exobiology, and personnel factors receive appropriate attention. Applied research receives the most emphasis, but references to fundamental studies and theoretical principles related to experimental development also qualify for inclusion. Each entry in the publication consists of a standard bibliographic citation accompanied, in most cases, by an abstract. Two indexes-subject and author are included after the abstract section.Langley Research CenterAEROSPACE MEDICINE; BIBLIOGRAPHIES; EXOBIOLOGY; INDEXES (DOCUMENTATION); BIOLOGICAL EFFECTS; LIFE SUPPORT SYSTEMS; PHARMACOLOGY; PHYSIOLOGICAL EFFECTS; PSYCHOLOGICAL EFFECTS; TOXICOLOGY; AEROSPACE ENVIRONMENTS; BIOASTRONAUTICS