Pediatric Adrenal Diseases

Written by experts and specialized investigators, this book presents a detailed overview of the recent progress in our understanding of the adrenal cortex and its pivotal roles in homeostasis. Genes, molecules and cell compartments directly or indirectly involved in the complex steroidogenesis pathway as well as the resulting end-hormones glucocorticoids, mineralocorticoids and androgens are analyzed. Furthermore, the defects of the genes responsible both for common and rare adrenal disorders are presented. The interactions of the adrenal cortices with the adrenal medulla and their importance in the integration of adrenocortical and adrenomedullary function are discussed. The complex molecular pathophysiology of congenital adrenal hyperplasia is presented; long-term effects of the disorder and the still controversial antenatal therapy are examined. Finally, expert review chapters discuss autoimmune Addison disease and the adrenoleukodystrophy/adrenomyeloneuropathy syndrome. Presenting novel research findings in adrenal gland physiology and pathophysiology, this book is a useful tool not only for pediatric endocrinologists, but also for clinicians and researchers studying human development, organogenesis, mitochondrial biology, nuclear receptors, stress biology and pharmacology.

Adrenal disease in children poses an immensely difficult diagnostic and management problem for the paediatrician in view of the large number of rare pathologies that may present in this way. This volume brings together the expertise of the acknowledged leaders in specific adrenal disorders to provide a readily accessible text that combines a detailed description of the molecular origins of these diseases, as they are currently understood, with a unique account of the clinical features and therapeutic options. Beginning with disorders that primarily affect adrenal development and progressing towards the defects that interfere with steroid production, the reader gains considerable insight into the normal physiology of the adrenal cortex particularly as revealed by clinical disorders. The major contributions of modern biochemistry and molecular genetics in our current understanding are visible throughout, providing a unique overview of adrenocortical biology. This book is of great interest to general pediatricians, paediatric endocrinologists, adult endocrinologists, clinical geneticists and basic scientists working in areas such as developmental biology and molecular steroidogenesis.

This Book Is Meant For Endocrinologists And Pediatricians. It Deals With The Various Hormone Defects That Children May Be Born With (For Example A Child With Growth Hormone Deficiency Will Be Of Short Stature). The Primary Objective Of The Book Is To Provide Useful And Practical Information That Can Be Used In The Indian Context.

This is a series of contemporary techniques and diagnostic advances for adrenal conditions. It covers various pathological alterations of adrenal glands, clarifying the more problematic areas of evaluation. It also focuses on newly-recognized entities, such as macronodular cortical hyperplasia.

Brought to you by the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference, Endocrinology: Adult and Pediatric: The Adrenal Gland is a new eBook that puts all of the latest advances in management of adrenal disorders at your fingertips. Instantly accessible on your favorite eReader, this adrenal endocrinology eBook makes it easy to give your patients the benefit of today's best expertise. Stay abreast of the newest knowledge and advances in adrenal disease, including the molecular genetics of pheochromocytomas and paragangliomas; the newest therapies for adrenocortical carcinoma, written by the organizers of the first major international trials; a survey of adrenal imaging, authored by the world's major diagnostic imaging specialist on cross-sectional CT and MR scanning of the adrenal gland; a comprehensive survey of adrenarche and the adrenopause - topics not adequately covered in most other adrenal endocrinology books; and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.

, Adrenal and Endocrine Tumors in Children' is the third volume in the series, 'Cancer Treatment and Research' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D' Angio and for che motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Child ren's Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

This book is designed to present a comprehensive and state-of the-art approach to the management of adrenal neoplasms that provides a resource to the broad group of providers that will encounter such a patient. Sections address issues that are faced by providers who encounter a patient with an adrenal neoplasm. These areas include an overview of the genetic basis and familial cancer syndrome-associated with adrenal neoplasms, pathobiology, advanced and tumor specific imaging approaches and technologies, biochemical analysis, standard medical and surgical therapies, and emerging technology and treatment approaches to benign and malignant adrenal neoplasms. Written by experts in the field, each of these sections address level of clinical evidence and provide recommendations and treatment algorithms. Extensive illustrations make this an interactive text. Management of Adrenal Masses in Children and Adults will serve as a very useful resource for all providers dealing with, and interested in this common but challenging tumor. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

Brought to you by the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference, Endocrinology: Adult and Pediatric: The Adrenal Gland is a new book that puts all of the latest advances in management of adrenal disorders at your fingertips. Stay abreast of the newest knowledge and advances in adrenal disease, including the molecular genetics of pheochromocytomas and paragangliomas; the newest therapies for adrenocortical carcinoma, written by the organizers of the first major international trials; a survey of adrenal imaging, authored by the world's major diagnostic imaging specialist on cross-sectional CT and MR scanning of the adrenal gland; a comprehensive survey of adrenarche and the adrenopause - topics not adequately covered in most other adrenal endocrinology books; and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide.

The book provides an authoritative source of knowledge about these problematic disorders. It bridges the gap between clinical recognition and the new molecular medicine. The editors, distinguished clinicians and geneticists, assembled an internationally renowned group of collaborators, many of them the experts who first described a particular disorder or established its present accepted definition. They have written a practical, comprehensive guide to the recognition, investigation and management of more than 60 recognised phakomatoses.