Pancreatic Diseases

This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.

Pancreatic diseases are a crucial issue not only because of their epidemiological significance, and their anatomical and metabolic complexity, but also because of the different treatment options available and their implications for surgery. Due to the slow but steady increase in the incidence of pancreatitis and pancreatic cancer, these diseases are today a real challenge for the surgeon. This volume presents the state of the art of surgery in the treatment of inflammatory and neoplastic pancreatic diseases, describing in detail the different approaches and their most relevant technical aspects. Also described are conventional and interventional radiology, operative endoscopy and endoscopic ultrasonography (which has recently acquired a diagnostic role), and adjuvant and neoadjuvant therapy for treatment or palliation: for only a multidisciplinary approach can produce a global vision, a winning strategy for the optimization of results. Along with the texts, all written by experts, the volume includes color images and drawings. It will prove itself a very useful tool in clinical practice.

This book is based on the latest comprehensive data about molecular mechanism of acute pancreatitis, chronic pancreatitis and pancreatic cancer. The diagnostic techniques including histology, radiology, sonography etc. are based on the sensitivity and specificity of the respective methods. Special focus is given to the indication and contraindication to surgical techniques. The book contains specific treatment modality and results for the first time after long-term outcome evaluation. There is detailed description of diagnosis and treatment, and the book is abundantly illustrated with approximately 300 color illustrations.

"This clearly laid out and easily readable encyclopedia is aimed particularly at general practitioners and students in their clinical years, as well as at specialists who desire a more in-depth knowledge of the pancreas, such as internists, gastroenterologists, surgeons, radiologists, oncologists, pathologists and pediatricians. But others will also find this to be a comprehensive reference book on the subject."--BOOK JACKET.

Questions & Answers About Diseases of the Pancreas provides authoritative and practical answers to the most common questions asked by patients and their loved ones. Providing both doctor and patient perspectives, this easy-to-read book is a comprehensive guide to the basics of pancreatic diseases, risk factors and prevention, diagnosis, treatment, survivorship, and life after diagnosis. Written by Dr. Timothy B. Gardner, Director of Pancreatic Disorders at Dartmouth-Hitchcock Medical Center, Questions & Answers About Disease of the Pancreas is an invaluable resource for anyone interested in learning what to expect after being diagnosed with pancreatitis, pancreatic cancer, pancreatic insufficiency, diabetes, cystic fibrosis or other pancreatic diseases.

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

This issue details the latest knowledge of early diagnosis, risk factors, limited surgical treatments, and novel therapies for pancreatic diseases. Clinicians will learn the most prognostic scoring systems for acute pancreatitis, review the basics for early management of the disease, and see how current practice guidelines have evolved. Advances in radiological imaging when applied to the pancreas have resulted in enhanced staging and improved selection for surgical intervention. Endoscopy of the pancreas via both ERCP and endoscopic ultrasound has led to unprecedented access and potential for non-operative intervention. Pancreatic surgery now takes advantage of both minimally invasive approaches and techniques learned from organ transplantation. These latest advances are addressed in this issue by key opinion leaders.

Pancreatic Disease: Basic Science and Clinical Management summarises the state of the art in basic science and clinical management of pancreatic disease. This book provides a clear and up-to-date review of the advancing areas in clinical pancreatology and clinical research related to the pancreas. Written by leading experts in the field, this comprehensive review directs the interested reader towards important and current published source material. Covering all aspects of pancreatic disease, contributions are included from pancreatic surgeons and medical pancreatologists on pancreatic cancer, acute pancreatitis and chronic pancreatitis. Special features include a systematic review of the evidence for the use of gemcitabine in pancreatic cancer prepared for the National Institute of Clinical Excellence (NICE), the UK body charged with evaluating new drug treatment. Gemcitabine has FDA approval. There are several contributions dealing with the management of pancreatic neuroendocrine tumours. This book will be useful to gastroenterologists, internists and surgeons, and specialist clinicians with an interest in pancreatic disease. Trainees in medical and surgical pancreatology will find it a companion to supplement standard textbooks.

Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.

Annotation. This publication presents new and fascinating insights especially into the pathogenesis of both acute and chronic pancreatitis. It starts with a literature review and presentation of the authors¿ own data on laboratory markers of acute pancreatitis such as trypsinogen, serum amyloid A and procalcitonin, paying special attention to their clinical usefulness and test performance for stratifying severity and monitoring disease progression. Also discussed is the still difficult differential diagnosis between pancreatic cancer and chronic pancreatitis, especially the early diagnosis of pancreatic cancer in preexisting chronic pancreatitis: particularly, the high specificity of molecular alterations in pancreatic cancer as found in some pilot studies has the potential of a strong complementary marker of malignancy in patients with a pancreatic mass of uncertain origin. Further topics discussed are acute-phase reactions during early pancreatic cellular injury, tropic pancreatitis, the pathogenesis of pain in chronic pancreatitis and the pathomechanisms of pancreatic fibrogenesis and the role of pancreatic stellate cells in the fibrotic process. Last but not least, endoscopic therapies in chronic pancreatitis are looked into.