New Therapeutic Approaches For Sars Cov 2 Covid 19

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. Covers computational based approaches for designing and repurposing drugs Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design Categorizes information about artificial intelligence-based drug screening and diagnostic tools

This update on SARS-CoV-2 focuses on basic knowledge about the virus and COVID-19 treatment. Chapters present basic information about the disease and its treatment. The virology, epidemiology, etiology, and damage response framework of SARS-CoV-2 are also discussed in detail. The book also covers recent topics of interest to pharmacology scholars such as the immunopathogenesis of SARS-CoV2, nanotechnology, repurposed drug treatments, COVID-19 vaccines, and phytomedicine for COVID-19 therapeutics. Readers in pharmacology, virology and medicine will find the book a simple, yet informative update on SARS-CoV-2 and COVID-19 treatment.

SARS-CoV-2, the coronavirus responsible for COVID-19, wreaked havoc on the world; it could both spread easily and mutate rapidly, leading to the decrease in the effectiveness of newly developed vaccines over time. The detection of these mutated variants and the development of more efficient vaccines requires significant effort and increased knowledge in this field. This new book, SARS-CoV-2 Variants and Global Population Vulnerability: Diagnostic Strategies, Vaccine Development, and Therapeutic Management, provides detailed and systemic information regarding the biology and immunophysiology of SARS-CoV-2 and highlights the global vulnerability of the world population to SARS-CoV-2 infection and COVID-19. The book covers different aspects pertaining to the SARS-CoV-2 variants and their relation to global vulnerability. Chapters discuss the diagnostics, vaccine development, and therapeutic management starting from the zoonotic origin, organization, and transmission of SARS-CoV-2, lifestyle and immunophysiology of the virus, detection and diagnosis techniques, and analytical techniques. The book also observes the global impact of Delta and Omicron SARS-CoV-2 variants. It looks at the drug repurposing and new drug discovery routines for the emerging variants. It presents strategies for fast-track vaccine development, the roles of nasal vaccines and nucleic acid vaccines for COVID-19 management, monoclonal antibody therapy for the diseases management, along with the use of dietary supplements and nutraceuticals, herbal drugs, and other alternative remedies for COVID-19 management. The book also considers the social and environmental impacts of SARS-CoV-2 variants and the current challenges, outlining aspects that can help in developing more efficacious means for controlling SARS-CoV-2 in the future. Key highlights: Discusses SARS-CoV-2 variants, diagnosis strategies, vaccine development, and the therapeutic management of the disease Provides comprehensive coverage of SARS-CoV-2 virus and variants With its unique and thorough take on the subject, this book is an important resource of know-how for investigators working in this area. Professionals from the pharmaceutical industry as well as students, research scholars, doctors, and other healthcare professionals will find this book of particular value.

Since the end of December 2019, the world has been battling with a global health emergency called COVID-19. This ongoing pandemic has claimed millions of lives worldwide and made a serious impact on global healthcare. The information and facts about the virus and the pandemic are constantly evolving, expanding and are present in a scattered manner. Above all, various rumors and false information are also spreading through word of mouth or social media in relation to the pandemic. In situations like this, it becomes hard for a common person as well as professionals to keep track of the fundamental concepts, ongoing scientific advancements and differentiate between the facts and myths. COVID-19 and SARS-CoV-2: The Science and Clinical Application of Conventional and Complementary Treatments covers the fundamental concepts regarding SARS-CoV-2 and COVID–19 as well as common concerns and issues ensuring optimal understanding of the latest basic science and clinical content. The comparative coverage of Conventional Medical Science with Complementary and Alternative Systems of Medicine in relation to the ongoing pandemic makes this book unique compared to other books available on COVID-19. Written in textbook format and in semi-technical style, it provides basic to advanced concepts and multidimensional clinical perspectives keeping in mind the diverse needs of academicians, researchers, students and common people. Key Features: Contains simple, lucid and concise presentation of contents Emphasizes core knowledge and concepts Presents evidence based and up to date information from a multidisciplinary perspective Includes illustrations with good quality diagrams and colored photographs for ease of understanding. COVID-19 and SARS-CoV-2 covers concepts and protocols from holistic perspective relating to core Molecular Biology of SARS-CoV-2, Clinical and Therapeutic Aspects, Multidisciplinary Treatment and Management Strategies like Conventional Pharmacological Treatments, Vaccines, Ayurveda, Homoeopathy, Holistic Nutrition Therapy, Nutraceutical Therapy, Biochemic Medicine, and Issues and Concerns relating to Public Health and Ongoing Advances in Research in relation to COVID-19. Written in semi-technical language easily understandable by readers from all domains, this book provides multidisciplinary perspective, knowledge and understanding regarding COVID-19 in one place, thus bridging the knowledge gap that exists between Conventional Sciences and Complementary and Alternative Medicine Systems.

Drug repurposing is a cost-effective method of discovering new treatments for diseases than traditional drug development methods. It involves virtual screening of chemical candidates with the aid of computational methods like molecular docking. Drug Repurposing against SARS-CoV2 focuses on current trends in drug repurposing against the novel coronavirus strains. The book aims to give readers an overview of drug repurposing against COVID-19 and various techniques involved in the process. The book consolidates available information on the pathophysiology, drug targets, and drug repurposing against COVID-19 into a single, convenient resource. Key features • An up-to-date compilation of the evidence that supports the drug repurposing for COVID-19. • How to use repurposing of available drugs for disease therapy. • Provides an improved understanding of pathophysiology and SARS-CoV2 viral entry pathways. • Provides references for further reading

Target recognition is important for the identification of drugs with a high target specificity and/or for the development of existing drugs that could be replicated for the treatment of SARS-CoV-2 infections. Since SARS-CoV-2 is a pathogen recently discovered, no specific medicines have been identified or are available at present. The scientific community had proposed list of current drugs with therapeutic potential for COVID-19 on the basis of genomic sequence information coupled with protein structure modeling, posing an effective and productive therapeutic approach for repurposing existing drugs. The possible therapeutics for the treatment of COVID-19 involves a wide range of alternatives, encompassing nucleic acid-based treatments directed at the expression of genes of viruses, cytokine therapy, genetic engineered and vectored antibodies, and different formulations of vaccines. The future prospective in the treatment approaches the exploration of antiviral therapy, such as screening of prevailing molecules or libraries, testing of existing broad-spectrum antiviral medications, modern drug discovery focused on genomic knowledge and biochemical properties of various coronaviruses to create new targeted drugs.

Even though knowledge about the impact of the pandemic on mental health is still very limited in all countries and is largely based on experiences only partially comparable to the current epidemic, such as those of the SARS or Ebola epidemics, it is likely that the need for intervention will increase significantly in the coming months and years. Scientific research in neuroscience is a growing field. It offers a novel perspective on the relationship between mind and brain and provides novel scenarios for understanding the long wave of the current pandemic. Furthermore, the pandemic has also led to the possibility of implementing remote monitoring and management interventions. This volume uses multidisciplinary approaches to physiological and cognitive mechanisms, medical treatment, psychosocial interventions, and self-management to help illustrate the complex association among the COVID-19 pandemic, neurological manifestations, mental health, and society.