New Frontiers In Gastroenterology And Hepatology

The branch of medicine concerned with the functioning of the digestive system along with the disorders affecting it, is known as gastroenterology. Hepatology is concerned with the functioning of the liver, pancreas, gallbladder and biliary tree. It studies the diseases and disorders related to them. Hepatology and gastroenterology are closely related fields of medicine. Colonoscopy, endoscopy, endoscopic ultrasound, liver biopsy are some of the common diagnostic and therapeutic procedures performed by gastroenterologists. This book unfolds the innovative aspects of gastroenterology, which will be crucial for the progress of this field in the future. It also unravels the recent studies in the field of hepatology. This book is a vital tool for all researching or studying gastroenterology and hepatology as it gives incredible insights into emerging trends.

The aim of this book is to describe holistic clinical approaches based on current advancements in the field of gastroenterology. The most significant developments in the treatment of gastrointestinal disorders and pathophysiology are elucidated in this bo

Assumptions made about alcohol, and beer in particular, are often based on media coverage, cultural stereotypes and even myths. Both the academic world and the brewing industry agree that ignorance may lead to prejudice. This books reflects their concern.

Rapid advances in stem cell biology have raised exciting possibilities of replacing damaged or lost tissues and cells by activation of in vitro-expanded stem cells or their progeny. This book examines many of the unresolved problems as well as future applications of regenerative medicine. In addition to animal experiments, results of research on human tissues and organs are included.

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

Dietary fibre research is rapidly evolving and is stimulated by the growing attention for intestinal health which is needed for combating major disorders such as diabetes, cardio-vascular diseases and obesity. Current research also explores relationships between fibres, the immune system and stress. The recently agreed EU and CODEX definitions for dietary fibre - including all polymeric carbohydrates not digested in the small intestine - provide both clarity and new challenges regarding adequate analysis and concerning the requirements for added fibre. Added fibre should have 'a physical effect of benefit to health as demonstrated by generally accepted scientific evidence to competent authorities'. Novel research tools from genomics toolboxes and advanced systems simulating the gastro-intestinal tract, are enabling researchers to obtain insights in the wide range of structure function relationships of different types of dietary fibre. These include the impact of dietary fibre on the gut microbiota and relationships between prebiotics and peptides involved in regulation of satiety and other functions. New technologies steadily increase the range of fibres, with and without anti-oxidants and other beneficial co-passengers, which are available to food processors. Dietary fibre - new frontiers for food and health covers the most up-to-date research available on dietary fibre and will be an indispensable tool for all scientists and technologists involved in research and development in this field.

There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.