Molecular And Cellular Approaches To The Control Of Proliferation And Differentiation

Molecular and Cellular Approaches to the Control of Proliferation and Differentiation focuses on molecular and cellular approaches used to control cell proliferation and differentiation. This book discusses the basic mechanisms involved in the regulation of cell growth, emphasizing the coupling of proliferation and the progressive expression of several specific cellular phenotypes. This text is organized into three sections encompassing 12 chapters and begins with an introduction to cell proliferation and how it is regulated by growth factors and nuclear protooncogenes in cell proliferation. The book then discusses mitosis and its investigation by means of the cell biological, genetic, biochemical, and immunological approaches, along with the model for mitotic regulation. The next chapters examine the manner in which cell structure is involved in the selective expression of genes associated with proliferation and differentiation and, how gene expression in response modulates both intracellular (nuclear matrix and cytoskeleton) and extracellular (extracellular matrix) architecture. The extent to which common signaling mechanisms and regulatory events are operative in the control of proliferation and differentiation is also addressed. The book concludes by analyzing the involvement of histone modifications in the condensation of mitotic chromosomes. This book is of interest to advanced undergraduate students, as well as to graduate students and researchers in genetics, cell biology, biological chemistry, microbiology, and immunology.

Stem Cell Proliferation and Differentiation, Volume 138, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on stem cell proliferation and differentiation

Molecular Control of Proliferation and Differentiation documents the proceedings of the 35th symposium of The Society for Developmental Biology entitled "Molecular Control of Proliferation and Differentiation," held at Asilomar, Monterey Peninsula, California, June 8-11, 1976. The contributions made by researchers at the symposium are organized into seven parts. Part I presents a paper on cell communication in embryological development. Part II includes studies on growth factors, including fibroblast growth factor and epidermal growth factor. Part III examines the factors affecting nerve cell differentiation and function. It includes papers on nerve growth factor and peptides as central nervous system neurotransmitters. Part IV focuses on cell interactions in blood cell development. It includes studies on factors affecting the differentiation of blood cells and the proliferation of hemopoietic stem cells in vitro. Part V examines cell interactions in the immune system. Part VI deals with cell interactions in organogenesis. Part VII covers the factors effecting differentiation in lower eukaryotes.

Cell Biology and Biotechnology: Novel Approaches to Increased Cellular Productivity contains the proceedings of the symposium by the same name held in Cambridge, Massachusetts, January 30 - February 2, 1992. State-of-the-art research is presented on: the IGF-1 Receptor and Gene Expression During the Cell Cycle; Attachment Control of Fibroplast Proliferation; Cell Biology and Serum-Free Mouse Embryo Cells; Immunoglobulin Production Stimulating Factors; Erythropoietin Control of Programmed Death in Erythroid Progenitors; Prohormone Processing Enzymes and Protein Production; Control of Translation Initiation by Phosphorylation; Protein Retention in the Endoplasmic Reticulum Mediated by GPR78; Molecular Approaches Towards Manipulating the Expression of the Glucose Related Proteins in Mammalian Cells; Protein Folding in the Endoplasmic Reticulum; Sorting of Membrane Proteins in the Endocytic and Exocytic Pathways; CIS-Acting Elements Which Regulate Immunoglobulin Gene Transcription.

Despite decades of work and financial support to explore the somatic mutation theory of carcinogenesis, we appear no nearer to explaining how cancer arises. This requires researchers to take stock and consider new hypotheses and alternative approaches to the study of control of cell proliferation, and cancer in particular. The Society of Cells is intended to encourage such a revaluation and proposes the adoption of new premises to explore these important subjects.

In 1974 The National Institute on Aging established a somatic cell genetic resource for aging research at the Institute for Medical Research in Camden, New Jersey. Within this program there is a yearly workshop to promote theory and concept develop ment in aging research with the specific purpose of addressing the use of genetically marked cells for aging research and to stimulate interest in aging research by workers in a variety of disciplines. This monograph, The Regulation of Cell Proliferation and Differentiation, is the result of the first workshop held May 15-17, 1975. The concept of the workshop was to consider two main areas: First, a discussion of clinical syndromes expressing as a major manifestation excessive growth, deficient growth or failure to thrive; and second, to present work in cellular and molecular biology on a model system suitable for in vitro study of regulation of cell proliferation and diff2rentiation. The model selected for this was skeletal muscle. It has been widely accepted that normal somatic cells from individual human donors display limited replicative lifespans when cultivated in vitro (1,2). That such "clonal senescence" may be related to in vivo aging is suggested by observations relating the replicative lifespans of cultures to donor age (3-5,13) donor genotype (4-7) and donor's tissue of origin (5,8). A variety of theories have been developed to explain in vitro clonal senescence (9).

Can the electric and magnetic fields (EMF) to which people are routinely exposed cause health effects? This volume assesses the data and draws conclusions about the consequences of human exposure to EMF. The committee examines what is known about three kinds of health effects associated with EMF: cancer, primarily childhood leukemia; reproduction and development; and neurobiological effects. This book provides a detailed discussion of hazard identification, dose-response assessment, exposure assessment, and risk characterization for each. Possible Health Effects of Exposure to Residential Electric and Magnetic Fields also discusses the tools available to measure exposure, common types of exposures, and what is known about the effects of exposure. The committee looks at correlations between EMF exposure and carcinogenesis, mutagenesis, neurobehavioral effects, reproductive and developmental effects, effects on melatonin and other neurochemicals, and effects on bone healing and stimulated cell growth.