Hyperlipidaemia And Atherosclerosis

This book, for physicians and health care workers, has chapters on epidemiology, clinical chemistry, nutrition, pharmacotherapy and behavior management for atherosclerosis in children and youth.

A distinguished team offer views on various controversies surrounding lipids and lipoproteins, including the management of special patient groups and the benefits of lipid lowering in the secondary prevention of heart disease

This book is aimed to accentuate the importance of hypercholesterolemia, since targeting and treating the hypercholesterolemia is increasingly well known as an essential strategy in the prevention of atherosclerosis-induced cardiovascular disease. It is important to look at hypercholesterolemia as it is proved to be crucial as well as the early stage of atherogenesis and can also be managed with appropriate treatment. This book describes the basics of hypercholesterolemia and its causes and various experimental animal models to understand and study the pathophysiology of hypercholesterolemia as well as to present practice-based clinical approaches to treat hypercholesterolemia. Further, the book describes various treatment strategies of hypercholesterolemia in detail, especially the appropriate use of statin. It is well known that the use of statin is an ideal as well as a potent therapy to lower cholesterol level and also has various beneficial pharmacological effects to prevent cardiovascular diseases. However, there exists less awareness about the use of statin. Hence, it is important to understand the appropriate use of statin in terms of doses for different stages of hypercholesterolemia, side effects, resistance of its use, and also interaction of statin with other drugs, which are well described in this book. In short, the major aim of this compendium is to present to the readers comprehensive, updated, and current research perspectives on hypercholesterolemia.

Abstract: This text attempts to summarize and interpret current understanding of the lipoproteins, their relationship to coronary heart disease, and methods of dealing with hyperlipoproteinemia clinically. This volume is intended for the medical practitioner who wants to be aware of recent developments and who wants to know how patients should be diagnosed and managed. Topics include: causes and prevention of atherosclerosis and coronary heart disease, lowering plasma cholesterol levels, classification and diagnosis of hyperlipidemia, and dietary and drug treatment of hyperlipidemia.

This timely, concise title provides an important update on clinical lipid management. Using information from recent clinical trials and in special populations, the book begins by offering an easy-to-read overview of LDL, HDL, and triglyceride metabolism and the genetics of lipid disorders. The link between inflammation and lipids, and how this relates to atherosclerosis development, is also addressed, as are the measures of subclinical atherosclerosis in patients with abnormal lipid levels. Lipid abnormalities in children, with a particular focus on vulnerable populations (with an emphasis on ethnicity and childhood obesity), are covered. The treatment goals and approaches for managing lipids in the clinic are thoroughly discussed, emphasizing the important role of statin use and addressing controversies of lipid management in special populations such as heart failure, end stage kidney disease and fatty liver disease. Of special note, an important update on how new HIV medications impact lipid levels is provided. In all, Lipid Management: From Basics to Clinic, is an invaluable, handy resource for understanding changes in lipids in different populations and for sharpening the clinical approach to managing complicated lipid cases.

The third edition of this well-received text provides a state-of-the-art treatise on modern clinical practice relating to hyperlipidaemia and lipoprotein disorders, conditions responsible for a huge amount of morbidity and mortality in Western countries and, increasingly, the developing world. The clinical evidence underlying the treatment of hyperlipidaemia has burgeoned since the second edition published in 1994, with the publication of the results of several clinical trials on statin drugs, and the subsequent appearance of national and international guidelines for cholesterol lowering in coronary prevention. There has also been considerable development in the definition of cardiovascular risk, and the methodology for identifying high-risk patients. All of these aspects are addressed fully in the new edition. In addition, the book offers helpful summaries of the background biochemistry of lipoprotein metabolism and atherosclerosis where relevant, putting the subject in the context of its pathophysiology and epidemiology. The text relating to clinical aspects has a strong evidence base, reviewing, in particular, areas of uncertainty and controversy. Drawing on the wealth of experience of the author, and representing his widely respected views on the subject, readers will find this comprehensive, well-referenced and accessible book invaluable.

Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.