Handbook Of Statistical Methods For Case Control Studies

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

Covers the fundamentals of case-control studies including important recent developments, with a focus on statistical analysis.

The case-control approach is a powerful method for investigating factors that may explain a particular event. It is extensively used in epidemiology to study disease incidence, one of the best-known examples being Bradford Hill and Doll's investigation of the possible connection between cigarette smoking and lung cancer. More recently, case-control studies have been increasingly used in other fields, including sociology and econometrics. With a particular focus on statistical analysis, this book is ideal for applied and theoretical statisticians wanting an up-to-date introduction to the field. It covers the fundamentals of case-control study design and analysis as well as more recent developments, including two-stage studies, case-only studies and methods for case-control sampling in time. The latter have important applications in large prospective cohorts which require case-control sampling designs to make efficient use of resources. More theoretical background is provided in an appendix for those new to the field.

Handbook of Statistical Analysis and Data Mining Applications, Second Edition, is a comprehensive professional reference book that guides business analysts, scientists, engineers and researchers, both academic and industrial, through all stages of data analysis, model building and implementation. The handbook helps users discern technical and business problems, understand the strengths and weaknesses of modern data mining algorithms and employ the right statistical methods for practical application. This book is an ideal reference for users who want to address massive and complex datasets with novel statistical approaches and be able to objectively evaluate analyses and solutions. It has clear, intuitive explanations of the principles and tools for solving problems using modern analytic techniques and discusses their application to real problems in ways accessible and beneficial to practitioners across several areas—from science and engineering, to medicine, academia and commerce. Includes input by practitioners for practitioners Includes tutorials in numerous fields of study that provide step-by-step instruction on how to use supplied tools to build models Contains practical advice from successful real-world implementations Brings together, in a single resource, all the information a beginner needs to understand the tools and issues in data mining to build successful data mining solutions Features clear, intuitive explanations of novel analytical tools and techniques, and their practical applications

Handbook of Regression Methods concisely covers numerous traditional, contemporary, and nonstandard regression methods. The handbook provides a broad overview of regression models, diagnostic procedures, and inference procedures, with emphasis on how these methods are applied. The organization of the handbook benefits both practitioners and researchers, who seek either to obtain a quick understanding of regression methods for specialized problems or to expand their own breadth of knowledge of regression topics. This handbook covers classic material about simple linear regression and multiple linear regression, including assumptions, effective visualizations, and inference procedures. It presents an overview of advanced diagnostic tests, remedial strategies, and model selection procedures. Finally, many chapters are devoted to a diverse range of topics, including censored regression, nonlinear regression, generalized linear models, and semiparametric regression. Features Presents a concise overview of a wide range of regression topics not usually covered in a single text Includes over 80 examples using nearly 70 real datasets, with results obtained using R Offers a Shiny app containing all examples, thus allowing access to the source code and the ability to interact with the analyses

This is a practical book on how to apply statistical methods successfully. The Authors have deliberately kept formulae to a minimum to enable the reader to concentrate on how to use the methods and to understand what the methods are for. Each method is introduced and used in a real situation from industry or research. Each chapter features situations based on the authors’ experience and looks at statistical methods for analysing data and, where appropriate, discusses the assumptions of these methods. Key features: Provides a practical hands-on manual for workplace applications. Introduces a broad range of statistical methods from confidence intervals to trend analysis. Combines realistic case studies and examples with a practical approach to statistical analysis. Features examples drawn from a wide range of industries including chemicals, petrochemicals, nuclear power, food and pharmaceuticals. Includes a supporting website, providing software to aid tutorials. Scientists and technologists of all levels who are required to design, conduct and analyse experiments will find this book to be essential reading.

Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.

Quantitative Research Methods for Health Professionals: A Practical Interactive Course is a superb introduction to epidemiology, biostatistics, and research methodology for the whole health care community. Drawing examples from a wide range of health research, this practical handbook covers important contemporary health research methods such as survival analysis, Cox regression, and meta-analysis, the understanding of which go beyond introductory concepts. The book includes self-assessment exercises throughout to help students explore and reflect on their understanding and a clear distinction is made between a) knowledge and concepts that all students should ensure they understand and b) those that can be pursued by students who wish to do so. The authors incorporate a program of practical exercises in SPSS using a prepared data set that helps to consolidate the theory and develop skills and confidence in data handling, analysis and interpretation.

1. Provides a comprehensive overview of meta-analysis methods and applications. 2. Divided into four major sub-topics, covering univariate meta-analysis, multivariate, applications and policy. 3. Designed to be suitable for graduate students and researchers new to the field. 4. Includes lots of real examples, with data and software code made available. 5. Chapters written by the leading researchers in the field.