Gene Expression And Its Discontents

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation.

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress. Characterized as friction and the fog-of-war by the Prussian military theorist Carl von Clausewitz, such conditions impair institutional cognition in real-time conflict and pose a real and continuing threat to organizations, such as the US military. In a linked collection of formal essays and a mathematical appendix, the book explores different aspects of cognitive and evolutionary process as conducted under the direction of doctrine that acts as a kind of genome for retention of what is learned through Lamarckian evolutionary selection pressures: armies and corporate entities learn from conflict, and incorporate that learning into their ongoing procedures. The book proposes models and policy solutions for strategic competence. A central feature of the book is a formal description of the famous OODA loop of the US military theorist John Boyd in terms of the Data Rate Theorem that links control and information theories. That description is expanded to cover more fully the impact of stochastic fog-of-war effects on tactical and operational scales of conflict. Subsequent chapters examine in more detail the role of doctrine, and the particular effect of embedding culture on cognitive and Lamarckian evolutionary processes associated with conflict on tactical, operational, and strategic scales and levels of organization. A scientifically sophisticated exercise in applied mathematics, history, evolutionary theory, and ecosystem theory, this book will be appropriate for researchers and students interested in defense, security, and international relations, as well as non-academic career professionals in government and industry.

The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecosystems constructed to maximize food yield and minimize risks of famine. Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur. This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.