From Lab To Market

The topic of this book, the commercialization of public-sector technology, continues to grow in importance in the United States and sirnilarsocieties. The issues involved are relevant to many roles including those of policy makers, managers, patent attorneys, licensing agents, and technical staff members of public technology sources. Institutions increasingly involved in the process include federal and other governmentallaboratories and their related agencies, public universities and their state governments, public and private transfer agents and, of course, all the private recipients of public technology. Scarcely a day goes by without a significant event related to technology transfer and commercialization. The popular business press is regularly carrying articles addressing the issues, explaining new initiatives and describing events of notable success or failure.[l] As an example of current important events, the Technology Reinvestment Project (TRP) is forrnu lating its initiatives totransfer public technology and promote technology-based publiclprivate partnerships as a collaboration between the Advanced Research Projects Agency (ARPA), the National Institute of Standards and Technology (NIST), the National Science Foundation (NSF) the National Aeronautics and Space Administration (NASA), and the Department of Energy, Defense Programs (DOE/DP).

This guide is written for biomedical innovators seeking to improve the lives of patients by translating innovative technologies into medical technologies. The contents are focused primarily on business principles that have been distilled from hundreds of projects as part of the Coulter Foundation's Translational Partners Program and Coulter Translational Reward Awards. To date, the Foundation has funded more than 600 projects, which in the first 11 years have raised close to $6 billion in funding.The course Concept to Clinic: Commercializing Innovation (C3i), offered by the National Institutes of Health (NIH), forms the basis of this Guide. This course has helped hundreds of university innovators, engineers, clinicians, and scientists learn how to commercialize the technologies they have developed in a very demanding market. The C3i program is based on the Coulter commercialization process, an approach to biomedical research translation developed and continuously refined by the Foundation in collaboration with its academic partners across the country.

In this book Part I presents first an overview of the ECHORD++ project, with its mission and vision together with a detailed structure of its functionalities and instruments: Experiments, Robotic Innovation Facilities and Public end-user Driven Technology Innovation PDTI. Chapter 1 explains how the project is born, the partners, the different instruments and the new concept of cascade funding projects. This novelty made ECHORD++ a special project along the huge number of research groups and consortia involved in the whole project. So far, it is the European funded project with more research team and partners involved in the robotic field. In Chapter 2, one of the instruments in ECHORD++ is explained in detail: RIF. Robotic innovation facilities are a set of laboratories across Europe funded with the project with the goal of hosting consortia involved in any experiment that have special needs when testing their robotic research. In the chapter the three different and specific RIFs will be described and analyzed. Chapter 3 explains an important instrument in ECHORD++: the Experiments. In this part, a big number of research groups have been involve in short time funded research projects. The chapter explains the management of such Experiments, from the call for participation, the candidate’s selection, the monitoring, reviews and funding for each of the 36 experiments funded for Echord. Chapter 4 is very special because it presents the innovation of funding public end-user driven technology, in particular, robotic technology. The robotic challenge is the key of such an instruments together with the management of the different consortia that participated competitively in the success of the robotic challenge proposed by a public entity, selected also with a very special and innovative process.

This guide is written for biomedical innovators seeking to improve the lives of patients bytranslating innovative technologies into medical technologies. The contents are focusedprimarily on business principles that have been distilled from hundreds of projects as part ofthe Coulter Foundation's Translational Partners Program and Coulter Translational RewardAwards. To date, the Foundation has funded more than 600 projects, which in the first 11 yearshave raised close to $6 billion in funding.The course Concept to Clinic: Commercializing Innovation (C3i), offered by the NationalInstitutes of Health (NIH), forms the basis of this Guide. This course has helped hundredsof university innovators, engineers, clinicians, and scientists learn how to commercialize thetechnologies they have developed in a very demanding market. The C3i program is basedon the Coulter commercialization process, an approach to biomedical research translationdeveloped and continuously refined by the Foundation in collaboration with its academicpartners across the country.

A complete overview of bioprinting, from fundamentals and essential topics to recent advances and future applications Additive manufacturing, also known as 3D printing, is one of the most transformative technological processes to emerge in recent decades. Its layer-by-layer construction method can create objects to remarkably precise specifications with minimal waste or energy consumption. Bioprinting, a related process that employs cells and biomaterials instead of man-made substances or industrial materials, has a range of biomedical and chemical uses that make it an exciting and fast-growing area of research. 3D Bioprinting from Lab to Industry offers a cutting-edge overview of this topic, its recent advances, and its future applications. Taking an interdisciplinary approach to a flourishing research field, this book exceeds all existing treatments of the subject in its scope and comprehensiveness. Moving from fundamental principles of the technology to its immense future potential, this is a must-own volume for scientists looking to incorporate this process into their research or product development. 3D Bioprinting from Lab to Industry readers will also find: Treatment of printing parameters, surface topography requirements, and much more Detailed discussion of topics including 5D printing in the medical field, dynamic tuning, the multi-material extrusion approach, and many others A complete account of the bioprinting process, from lab requirements to commercialization 3D Bioprinting from Lab to Industry is ideal for researchers—graduate and post-doctoral scholars—in the areas of materials science, biomedical engineering, chemical engineering, biotechnology, and biochemistry.

In terms of becoming a successful bioentrepreneur, there is still much more to learn. There are many ways to learn the essential fundamentals of entrepreneurship, including through the mistakes of previous businesses and models. Increased knowledge and a better understanding of what works can be derived from these previous failures and mistakes. Additionally, learning from other bioentrepreneurs can help businesses run successfully. By looking deeper into business models, product development, the fundamental concepts of bioentrepreneurship, and the essential characteristics of bioentrepreneurs, one can become better equipped to understand the role of biological sciences in entrepreneurship, specifically the role of product development. Bioentrepreneurship and Transferring Technology Into Product Development provides a comprehensive understanding of the role of biological sciences, specifically in transforming technology into commercial product. This book compiles the theoretical and practical aspects of bioentrepreneurship and discusses the various factors, including creating business plans, acquiring funding, and successful business models. The chapters also cover areas such as small-scale product development, intellectual property rights, funding schemes for start-ups, and new prospective biotechnology product development. This book is essential for bioentrepreneurs, entrepreneurs, product developers, scientists, practitioners, researchers, academicians, and students interested in product development from a biological science perspective.

Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications. Contains a comprehensive review of non-parenteral nanomedicines Provides analysis of non-parenteral methods of nanomedicines including regulatory implications and future applications Explores a wide range of promising approaches for non-parenteral drug delivery using the latest advancement in nanomedicine written by experts in industry and academia

This book covers various technological aspects of sustainableenergy ecosystems and processes that improve energy efficiency, andreduce and sequestrate carbon dioxide (CO2) and othergreenhouse emissions. Papers emphasize the need for sustainabletechnologies in extractive metallurgy, materials processing andmanufacturing industries with reduced energy consumption andCO2 emission. Industrial energy efficient technologiesinclude innovative ore beneficiation, smelting technologies,recycling, and waste heat recovery. The book also containscontributions from all areas of non-nuclear and non-traditionalenergy sources, including renewable energy sources such as solar,wind, and biomass. Papers from the following symposia are presented in thebook: Energy Technologiesand Carbon Dioxide Management Recycling andSustainability Update Magnetic Materialsfor Energy Applications V Sustainable Energyand Layered Double Hydroxides High-temperatureSystems for Energy Conversion and Storage Structural Materials,Heat Transport Fluids, and Novel System Designs for High Power andProcess Heat Generation