Freedom Trials

Evelyn Summers is imprisoned for a crime that was wiped from her memory. In order for Evelyn to be released, she—along with other “reformed” prisoners—must pass seven mental, physical, and virtual challenges known as the Freedom Trials. One mistake means execution and, with her history of being a snitch, her fellow inmates will do everything they can to get revenge. When new prisoner Alex Martinez arrives, armed with secrets about Evelyn’s missing memories, she must make a choice. She can follow the rules to win and walk free, or covertly uncover details of the crime that sent her there. But competing in the trials and dredging up her erased past may cost Evelyn the one thing more valuable than freedom: her life.

Evelyn Summers is imprisoned for a crime that was wiped from her memory. In order for Evelyn to be released, she—along with other “reformed” prisoners—must pass seven mental, physical, and virtual challenges known as the Freedom Trials. One mistake means execution and, with her history of being a snitch, her fellow inmates will do everything they can to get revenge. When new prisoner Alex Martinez arrives, armed with secrets about Evelyn’s missing memories, she must make a choice. She can follow the rules to win and walk free, or covertly uncover details of the crime that sent her there. But competing in the trials and dredging up her erased past may cost Evelyn the one thing more valuable than freedom: her life.

Before 1854, most Northerners managed to ignore the distant unpleasantness of slavery. But that year an escaped Virginia slave, Anthony Burns, was captured and brought to trial in Boston--and never again could Northerners look the other way. This is the story of Burns's trial and of how, arising in abolitionist Boston just as the incendiary Kansas-Nebraska Act took effect, it revolutionized the moral and political climate in Massachusetts and sent shock waves through the nation. In a searching cultural analysis, Albert J. von Frank draws us into the drama and the consequences of the case. He introduces the individuals who contended over the fate of the barely literate twenty-year-old runaway slave--figures as famous as Richard Henry Dana Jr., the defense attorney, as colorful as Thomas Wentworth Higginson and Bronson Alcott, who led a mob against the courthouse where Burns was held, and as intriguing as Moncure Conway, the Virginia-born abolitionist who spied on Burns's master. The story is one of desperate acts, even murder--a special deputy slain at the courthouse door--but it is also steeped in ideas. Von Frank links the deeds and rhetoric surrounding the Burns case to New England Transcendentalism, principally that of Ralph Waldo Emerson. His book is thus also a study of how ideas relate to social change, exemplified in the art and expression of Emerson, Henry Thoreau, Theodore Parker, Bronson Alcott, Walt Whitman, and others. Situated at a politically critical moment--with the Whig party collapsing and the Republican arising, with provocations and ever hotter rhetoric intensifying regional tensions--the case of Anthony Burns appears here as the most important fugitive slave case in American history. A stirring work of intellectual and cultural history, this book shows how the Burns affair brought slavery home to the people of Boston and brought the nation that much closer to the Civil War.

The Confederacy lost the Civil War but quickly began to win the peace when a mysterious organization arose called the Ku Klux Klan. The Ku Klux, as it was then called, sought to restore white supremacy by terrorizing the formerly enslaved to prevent them from voting or owning firearms. To support Black resistance to the KKK’s campaign of murder and mayhem, President Ulysses S. Grant suspended the writ of habeas corpus in large portions of South Carolina and sent the famed 7th Cavalry to make mass arrests. Grant’s new attorney general, the first former Confederate to serve in a presidential Cabinet and an ardent advocate for Black equality, Amos T. Akerman, aggressively prosecuted the Ku Klux in a series of sensational trials that shocked the nation and forced a reckoning regarding just how much the Civil War and the recently enacted Fourteenth and Fifteenth amendments to the Constitution had changed America and its notions of citizenship. Highlighting forgotten Black and white civil rights pioneers and weaving in the story of the author’s own great-grandfather’s crimes as a member of the Ku Klux Klan, Freedom on Trial tells a gripping story of a moment pregnant with promise when race relations in the United States might have taken a dramatically different turn. It is a story that also offers a sober lesson for those engaged in the ongoing work of fulfilling the American promise of equality for all.

Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every key aspect of preparing and conducting clinical trials, including: Interdisciplinary topics that have to be coordinated for a successful clinical trialData management (and adverse event reporting systems) Biostatistics, pharmacology, and toxicology Modeling and simulation Regulatory monitoring and ethics Particular issues for given disease areas-cardiology, oncology, cognitive, dementia, dermatology, neuroscience, and more With unique information on such current issues as adverse event reporting (AER) systems, adaptive trial designs, and crossover trial designs, Clinical Trials Handbook will be a ready reference for pharmaceutical scientists, statisticians, researchers, and the many other professionals involved in drug development.

Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.

Community or group-randomized trials, which are usually done to evaluate the effect of health promotion effors. It reviews the underlying issues, describes the most widely used research design, and presents the many approaches to analysis that are now available.

Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.

This illuminating graphic novel biography about Harriet Tubman sheds new light on one of American history's bravest heroes. ​Harriet Tubman did something exceptionally courageous: She escaped slavery. Then she did something impossible: She went back. She underwent some thirteen missions to rescue around seventy enslaved people, using and expanding a network of abolitionists that became known as the Underground Railroad. She spent her life as an activist, speaking out for Black people and women's suffrage. This modern account of her trip to save her brothers is detailed and authentic. Illustrated with care for the historical record, it offers insight into the life and mind of Tubman, displaying her as a woman with an unshakable desire to break the chains of an unjust society. It is a perfect anti-racist narrative for our times and deepens an understanding of just what freedom means to those who must fight for it.