Foundation Of Cellular Neurophysiology

with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.

Molecular and Cellular Physiology of Neurons: Second Edition is a comprehensive, up-to-date introduction to essential concepts of cellular neuroscience. Emphasizing experimental approaches and recent discoveries, it provides an in-depth look at the structure and function of nerve cells, from protein receptors and synapses to the biochemical processes that drive the mammalian nervous system. Starting with the basics of electrical current flow across cell membranes, Gordon Fain covers voltage gating and receptor activation in the context of channel diversity, excitatory and inhibitory synaptic transmission, neuromodulation, and sensory transduction. Emphasizing long-term processes of synaptic potentiation and depression involved in memory, consciousness, and attention, he demonstrates how cells produce neural signals and regulate signal flow to enhance or impede cell-to-cell communication. Fain also addresses the relation of molecular and cellular mechanisms to evolving theories of neurological disease and addiction. Enhanced by more than two hundred illustrations, Molecular and Cellular Physiology of Neurons: Second Edition is intended for anyone who seeks to understand the fundamentals of nerve cell function, including undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries in molecular and cellular neurophysiology.

First published in 1975. Because of its general importance to a number of related disciplines, students of the modern science of neurophysiology have benefited from time to time from an introductory survey presented at a more elementary level than is usually found in advanced textbooks. The dynamism of the field is such, however, that more up-to-date statements incorporating many of the exciting new findings concerning cellular neurophysiology are required periodically. This text is aimed at filling that need. It is an outgrowth of a part of a course on the neurophysiology of sensory processes taught by the author at The University of Michigan during the last ten years. This book is an attempt to present the subject matter at a level appropriate for advanced undergraduate students and first year graduate students whose knowledge of chemistry, physics, and mathematics is limited to introductory courses.

Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes