First Signals

The enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it.

The enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it.

Kicking of a new four-book series by an Air Force Reserve captain and UFO authority, this title explores the future evolution of man and machine, in which the search for intelligent life becomes the catalyst of man's dreams--and the stars, man's destination. Original.

Brian Skyrms offers a fascinating demonstration of how fundamental signals are to our world. He uses various scientific tools to investigate how meaning and communication develop. Signals operate in networks of senders and receivers at all levels of life, transmitting and processing information. That is how humans and animals think and interact.

A widely celebrated novelist gives us a generous collection of exhilarating short stories, proving that he is a master of this genre as well. Once again, "he reminds us," wrote The Miami Herald, "that great writing is a timeless art." After the stunning historical novels The Clearing and The Missing, Tim Gautreaux now ranges freely through contemporary life with twelve new stories and eight from previous collections. Most are set in his beloved Louisiana, many hard by or on the Mississippi River, others in North Carolina and even in midwinter Minnesota. But generally it's heat, humidity, and bugs that beset his people as they wrestle with affairs of the heart, matters of faith, and the pros and cons of tight-knit communities--a remarkable cast of characters, primarily of the working class, proud and knowledgeable about the natural or mechanical world, their lives marked by a prized stereo or a magical sewing machine retrieved from a locked safe, boats and card games and casinos, grandparents and grandchildren and those in between, their experiences leading them to the ridiculous or the scarifying or the sublime; most of them striving for what's right and good, others tearing off in the opposite direction.

In this book the author, an investigative journalist, traces the social history of marijuana from its origins to its emergence in the 1960s as a defining force in an ongoing culture war. He describes how the illicit marijuana subculture overcame government opposition and morphed into a multibillion-dollar industry. In 1996, Californians voted to legalize marijuana for medicinal purposes. Similar laws have followed in several other states, but not without antagonistic responses from federal, state, and local law enforcement. The author draws attention to underreported scientific breakthroughs that are reshaping the therapeutic landscape: medical researchers have developed promising treatments for cancer, heart disease, Alzheimer's, diabetes, chronic pain, and many other conditions that are beyond the reach of conventional cures. This book is an examination of the medical, recreational, scientific, and economic dimensions of the world's most controversial plant.

A unified treatment of the generation and analysis of brain-generated electromagnetic fields. In Brain Signals, Risto Ilmoniemi and Jukka Sarvas present the basic physical and mathematical principles of magnetoencephalography (MEG) and electroencephalography (EEG), describing what kind of information is available in the neuroelectromagnetic field and how the measured MEG and EEG signals can be analyzed. Unlike most previous works on these topics, which have been collections of writings by different authors using different conventions, this book presents the material in a unified manner, providing the reader with a thorough understanding of basic principles and a firm basis for analyzing data generated by MEG and EEG. The book first provides a brief introduction to brain states and the early history of EEG and MEG, describes the generation of electromagnetic fields by neuronal activity, and discusses the electromagnetic forward problem. The authors then turn to EEG and MEG analysis, offering a review of linear and matrix algebra and basic statistics needed for analysis of the data, and presenting several analysis methods: dipole fitting; the minimum norm estimate (MNE); beamforming; the multiple signal classification algorithm (MUSIC), including RAP-MUSIC with the RAP dilemma and TRAP-MUSIC, which removes the RAP dilemma; independent component analysis (ICA); and blind source separation (BSS) with joint diagonalization.

First demonstrated in 1928, color television remained little more than a novelty for decades as the industry struggled with the considerable technical, regulatory, commercial, and cultural complications posed by the medium. Only fully adopted by all three networks in the 1960s, color television was imagined as a new way of seeing that was distinct from both monochrome television and other forms of color media. It also inspired compelling popular, scientific, and industry conversations about the use and meaning of color and its effects on emotions, vision, and desire. In Bright Signals Susan Murray traces these wide-ranging debates within and beyond the television industry, positioning the story of color television, which was replete with false starts, failure, and ingenuity, as central to the broader history of twentieth-century visual culture. In so doing, she shows how color television disrupted and reframed the very idea of television while it simultaneously revealed the tensions about technology's relationship to consumerism, human sight, and the natural world.

"One of the more momentous books of the decade." —The New York Times Book Review Nate Silver built an innovative system for predicting baseball performance, predicted the 2008 election within a hair’s breadth, and became a national sensation as a blogger—all by the time he was thirty. He solidified his standing as the nation's foremost political forecaster with his near perfect prediction of the 2012 election. Silver is the founder and editor in chief of the website FiveThirtyEight. Drawing on his own groundbreaking work, Silver examines the world of prediction, investigating how we can distinguish a true signal from a universe of noisy data. Most predictions fail, often at great cost to society, because most of us have a poor understanding of probability and uncertainty. Both experts and laypeople mistake more confident predictions for more accurate ones. But overconfidence is often the reason for failure. If our appreciation of uncertainty improves, our predictions can get better too. This is the “prediction paradox”: The more humility we have about our ability to make predictions, the more successful we can be in planning for the future. In keeping with his own aim to seek truth from data, Silver visits the most successful forecasters in a range of areas, from hurricanes to baseball to global pandemics, from the poker table to the stock market, from Capitol Hill to the NBA. He explains and evaluates how these forecasters think and what bonds they share. What lies behind their success? Are they good—or just lucky? What patterns have they unraveled? And are their forecasts really right? He explores unanticipated commonalities and exposes unexpected juxtapositions. And sometimes, it is not so much how good a prediction is in an absolute sense that matters but how good it is relative to the competition. In other cases, prediction is still a very rudimentary—and dangerous—science. Silver observes that the most accurate forecasters tend to have a superior command of probability, and they tend to be both humble and hardworking. They distinguish the predictable from the unpredictable, and they notice a thousand little details that lead them closer to the truth. Because of their appreciation of probability, they can distinguish the signal from the noise. With everything from the health of the global economy to our ability to fight terrorism dependent on the quality of our predictions, Nate Silver’s insights are an essential read.