Ethnopharmacology And Omics Advances In Medicinal Plants

The book explores the world of medicinal plants through a groundbreaking and comprehensive book. It delves into high-throughput technologies and multi-omics approaches to unlock the untapped potential of endophytic fungi, revealing novel bioactive compounds. It further talks about the diverse biodiversity and ethnopharmacological knowledge, unravelling the molecular intricacies of secondary metabolites under varying ecological conditions. This gives insights into medicinal plant research, offering cutting-edge insights into genome-based barcoding, nanotechnology, and functional genomics for revolutionary drug discoveries. From proteomic and epigenomic analysis to big data exploration, this book presents a holistic view of medicinal plants' potential and discusses the latest advancements in micropropagation, agronomical approaches, and genome editing, paving the way for transformative medicines and healthcare breakthroughs. It serves as a great resource for academicians, researchers, and pharmacologists.

This book delves into diverse facets and applications of medicinal plants. It discusses the metabolic, transcriptomic, and genomic intricacies of medicinal plants, shedding light on their chemical compositions, genetic makeup, and regulatory mechanisms. It includes a chapter on nanotechnology, investigating the influence of nanoparticles on medicinal plants. Subsequent chapters explore functional genomics and genome editing, showcasing innovative approaches to modifying plant genetics. It also discusses plant-associated microorganisms in the microbiome and endophytic fungi. Furthermore, the book addresses the critical issues of genetic diversity, agrotechnology for sustainable production, intellectual property rights, and the impact of various stresses on medicinal plants. This book serves as a valuable resource for researchers, educators, and students of pharmacology, offering a comprehensive understanding of medicinal plants and their evolving role in science and medicine.

The purpose of this book is to discuss several medicinal plants to find wider application in the domain of medicinal, clinical, and pharmaceutical treatment. Recent Advances in Plant-Based, Traditional, and Natural Medicines serves as a useful source of ideas and an inspiration for further cell and molecular biology research toward developing drugs and treatments from these traditional and plant-based remedies. The book covers a variety of topics and: • Considers the current state of research of traditional and plant-based medicines • Covers the current status of ethnomedicine and medicinal plant discovery • Presents the clinical applications of traditional and plant-based medicines

For hundreds of years, indigenous populations have developed drugs based on medicinal plants. Many practitioners, especially advocates of traditional medicine, continue to support the use of plants and functional foods as methods by which many ailments can be treated. With relevance around the world as a complementary and alternative medicine, advancements for the use of both ethnopharmacology and nutraceuticals in disease must continually be explored, especially as society works to combat chronic illnesses, increasingly resilient infectious diseases, and pain management controversies. The Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals discusses the advancements made in herbal medicines and functional foods that can be used as alternative medical treatments for a variety of illness and chronic diseases. The anthology will further explain the benefits that they provide as well as the possible harm they may do without proper research on the subject. Covering topics such as food additives, dietary supplements, and physiological benefits, this text is an important resource for dieticians, pharmacists, doctors, nurses, medical professionals, medical students, hospital administrators, researchers, and academicians.

Ethnopharmacology and Biodiversity of Medicinal Plants provides a multitude of contemporary views on the diversity of medicinal plants, discussing both their traditional uses and therapeutic claims. This book emphasizes the importance of cataloging ethnomedical information as well as examining and preserving the diversity of traditional medicines. It also discusses the challenges present with limited access to modern medicine and the ways in which research can be conducted to enhance these modern practices. The book also explores the conservation procedures for endangered plant species and discusses their relevance to ethnopharmacology. Each chapter of this book relays the research of experts in the field who conducted research in diverse landscapes of India, providing a detailed account of the basic and applied approaches of ethnobotany and ethnopharmacology. The book reviews multiple processes pertaining to medicinal plants, such as collecting the traditional therapeutic values and validation methods. It also explores developments in the field such as the diversity and medicinal potential of unexplored plant species and applications in drug formulation to fight against anti-microbial resistance (AMR).

Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protection, key analytical approaches, the role of ethnopharmacology in primary/secondary education and links to biodiversity and ecological research. Part two looks at ethnopharmacological contributions to modern therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally. A comprehensive, critical synthesis of the latest developments in ethnopharmacology. Includes a section devoted to ethnopharmacological contributions to modern therapeutics across a range of conditions. Contributions are from leading international experts in the field. This timely book will prove invaluable for researchers and students across a range of subjects including ethnopharmacology, ethnobotany, medicinal plant research and natural products research. Ethnopharmacology- A Reader is part of the ULLA Series in Pharmaceutical Sciences www.ullapharmsci.org

Ethnopharmacology is a multidisciplinary subject and an area of research where tradition and modern science coexists. The progress of this interdisciplinary science is expanding fast with our increasing quest for phytopharmaceuticals and our increasing awareness on traditional and alternative systems of medicines. The book is a compilation of articles written by eminent researchers working on phytomedicine and on various aspects of ethnopharmacology. Many of the articles are modern approaches to ethnopharmacological research. The book will be immensely useful to students, teachers, scientists and pharmaceutical industries interested in plant based medicine and drug development. Contents Chapter 1: Mechanisms of Apoptosis Induced by Garlic-Derived Components by D Karunagaran and Suby Oommen; Chapter 2: Music Therapy: An Introduction by T V Sairam; Chapter 3: Application of Traditional Knowledge of Medicinal Plants by Tribes of Some Part of Rajasthan; Chapter 4: An Experimental Evaluation to the Anticancer Activity of Homeopathic Medicines by Ramadasan Kuttan, Girija Kuttan, E S Sunila, K C Preethi, C Nimita Venugopal and K B Hari Kumar; Chapter 5: Molecular Mechanisms Underlying Immunomodulatory Effects of Viscum album Preparations by Fabienne Prost, Jean-Paul Duong Van Huyen, Sriramulu Elluru, Sandrime Delignat, Jagadeesh Bayry, Michel D Kazatchkine and Srini V Kaveri; Chapter 6: A Rasayana, ICHOR-CR as a Possible Chemoprotectant Againt Doxorubicin-Related Toxicity by Renee Vanessa Gardner, Hernan Correa, Randall Craver, Evangeline Mckinnon, Halina Sadowska-Krowicka and Rajasekharan Warrier; Chapter 7: Ethnomedicinal Potential of Herbal Drugs on Gastric Dysfunction in Experimental Animals by Ch V Rao and P Pushpangadam; Chapter 8: Anti-inflammatory, Anti-inflammatory, Antinociceptive and Diuretic Activities of Amoora cucullata Roxb by A K Das, I Z Shahid, M S K Choudhuri, J A Shilpi and Firoj Ahmed; Chapter 9: The Role of Ethnomedical Leads in Drug Discovery by V George and J Anil John; Chapter 10: Quality of Natural Health Products through Marker Profiling: Promotion and International Coordination by Pulok K Mukherjee, V Kumar, Peter J Houghton; Chapter 11: Potential Use of Some Natural Compounds as Radioprotectors C K K Nair; Chapter 12: Resveratrol Miracle: From Chemoprevention to Cardioprotection by Samarjit Das and Dipak K Das; Chapter 13: Protective Effect of Phytochemicals in Cancer Chemoprevention, Wound Healing and Ischemia-Reperfusion Injury by Rajesh L Thangapazham, Anuj Sharma, and Radha K Maheshwari; Chapter 14: A Brief Review on Phytoconstituents with Potential Antidiabetic Activity by K Rajendran and Annie Shirwaikar; Chapter 15: Scientific Evaluation of Traditional Medicine: Ethnopharmacology, Reverse Pharmacology, System Biology to Metabolmics by Palpu Pushpangadan, R Govindarajan, S K Srivastava, Ch V Rao, K Narayanan Nair, A K S Rawat, Shanta Mehrotra, A K Sharma, S Rajasekharan, V George and P G Latha; Chapter 16: Biological Diversity in Curcuma: A Review by Sharad Srivastava, A K S Rawat and Shanta Mehrotra; Chapter 17: Therapeutic Potential of Medicinal Mushrooms Occurring in South India Amelioration of Oxidative Stress-Induced Hepato-Renal Damages: A Pre-Clinical Evaluation by T A Ajith and K K Janardhanan; Chapter 18: Traditional Medicine and the Intellectual Property Rights (IPR) Regime of 21st Century by Palpu Pushpangadam; Chapter 19: Antimitotic Polysaccharide from Punica granatum by T T Sreelekha, K K Vijayan, Prabha Balaram; Chapter 20: Documentation of Traditional Knowledge and IPR Protection Related to Plants Used for Food and Medicine by S Rajasekharan, P G Latha and P Pushpangadan

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.

This book highlights the latest international research on different aspects of medicinal plants and fungi. Studies over the last decade have demonstrated that bioactive compounds isolated from medicinal fungi have promising antitumor, cardiovascular, immunomodulatory, anti-allergic, anti-diabetic, and hepatoprotective properties. In the light of these studies, the book includes chapters (mostly review articles) by eminent researchers from twelve countries across the globe working in different disciplines of medicinal plants and fungi. It discusses topics such as the prevention of major neurodegenerative and neurotoxic mechanisms by Centella asiatica; the medicinal properties and therapeutic applications of several mushrooms species found in different parts of the world; and fungal endophytes as a source of bioactive metabolites including anticancer and cardioprotective agents. There are also chapters on strategies for identifying bioactive secondary metabolites of fungal origin; the use of genomic information to explore the biotechnological potential of medicinal mushrooms; and solid state fermentation of agro-industrial and forestry residues for the production of medicinal mushrooms. It is a valuable resource for the researchers, professionals and students working in the area of medicinal plants and fungi.

Medicinal Plants: Chemistry, Biology and Omics reviews the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plant tribes and genera, and their relevance to drug efficacy. Medicinal plants provide a myriad of pharmaceutically active components, which have been commonly used in traditional Chinese medicine and worldwide for thousands of years. Increasing interest in plant-based medicinal resources has led to additional discoveries of many novel compounds, in various angiosperm and gymnosperm species, and investigations on their chemotaxonomy, molecular phylogeny and pharmacology. Chapters in this book explore the interrelationship within traditional Chinese medicinal plant groups and between Chinese species and species outside of China. Chapters also discuss the incongruence between chemotaxonomy and molecular phylogeny, concluding with chapters on systems biology and “-omics technologies (genomics, transcriptomics, proteomics, and metabolomics), and how they will play an increasingly important role in future pharmaceutical research. Reviews best practice and essential developments in medicinal plant chemistry and biology Discusses the principles and applications of various techniques used to discover medicinal compounds Explores the analysis and classification of novel plant-based medicinal compounds Includes case studies on pharmaphylogeny Compares and integrates traditional knowledge and current perception of worldwide medicinal plants