Early Trauma As The Origin Of Chronic Inflammation

The aim of the book is to sensitize physicians and researchers to the important long-term health effects of early, persistent, and severe trauma. The author, an internist, rheumatologist, and basic researcher in psychoneuroimmunology, shows connections between adverse childhood experiences and typical adult sequelae. After early traumatic experiences and childhood stress, there is a higher incidence of mental illness, chronic pain, sleep disorders, dental problems, obesity, cardiovascular disease, asthma, diabetes mellitus and chronic inflammation. A selection of diseases unmistakably demonstrate the long-term consequences of early childhood trauma. These childhood experiences create a kind of long-term programming that has a negative effect in adulthood. From his psychoneuroimmunological perspective, Rainer Straub identifies four factors that link the brain to the immune system and are involved in chronic immune activation: direct connectors originating in the brain, indirect connectors functioning through hormonal and neuronal pathways, extracorporeal (the environmental factors) and pleiotropic (genetic factors) connectors. The author Prof. Rainer H. Straub, MD, is Professor of Experimental Medicine and is rheumatologist. He heads the Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine at the University Hospital Regensburg. His nonfiction books "Understanding Aging, Fatigue, and Inflammation" (2018) and "Three Memories for the Body" (2020) have been published by Springer. The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

The aim of the book is to sensitize physicians and researchers to the important long-term health effects of early, persistent, and severe trauma. The author, an internist, rheumatologist, and basic researcher in psychoneuroimmunology, shows connections between adverse childhood experiences and typical adult sequelae. After early traumatic experiences and childhood stress, there is a higher incidence of mental illness, chronic pain, sleep disorders, dental problems, obesity, cardiovascular disease, asthma, diabetes mellitus and chronic inflammation. A selection of diseases unmistakably demonstrate the long-term consequences of early childhood trauma. These childhood experiences create a kind of long-term programming that has a negative effect in adulthood. From his psychoneuroimmunological perspective, Rainer Straub identifies four factors that link the brain to the immune system and are involved in chronic immune activation: direct connectors originating from the brain, indirect connectors functioning through hormonal and neuronal pathways, extracorporeal (the environmental factors) and pleiotropic connectors (genetic factors). The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

A pioneering physician reveals how childhood stress leads to lifelong health problems, and what we can do to break the cycle.

This volume collects the state-of-the-art applications of psychological theory to the interactions among the mind, the nervous system, and the immune system, including applications drawn from affective science, developmental psychology, behavioral neuroscience, and clinical psychology.

Originally published by Viking Penguin, 2014.

Tender Paws takes a deep dive into the practical benefits of applying therapeutic parenting best practices to dogs in our care. When Wendy Lyons Sunshine got her first puppy—abandoned behind a gas station, struggling with worms and anemia—she was in over her head. As puppy training guides failed to help her with the out-of-control, traumatized bundle of teeth and claws rescue pup, she turned to her work helping world-class child development experts. Could strategies for raising happy, well-adjusted kids transfer to a puppy? As it turns out, yes, they can! From the first try, parenting wisdom transformed Sunshine’s relationship with her challenging little one. Soon enough, Sunshine’s view of her puppy shifted from one of adversity to one of compassion and understanding, and she was able to bring patience and therapeutic concepts to meet her dog’s needs. When Sunshine reached out to experts, they affirmed that science-based principles used with at-risk children align well with best practices of holistic, positive, and progressive dog handling. Exploring parallels between human and canine research, attachment styles, history of trauma, parenting styles, and her own “inner child” proved a mindful path for pet parenting. Far from a standard dog training manual, Tender Paws explicitly applies parenting wisdom and best practices used with special needs kids to a cross-section of scenarios, from recognizing developmental trauma and unmet core needs, to making decisions about appropriate equipment, to responding to difficult behavior, to understanding the parenting style from which we approach our dogs. Sunshine empowers you and your dog by offering: A synthesis of the fields of child development, attachment, trauma, sensory integration, neurobiology, learning, animal behavior, and ethology. A problem-solving framework that makes dog training decisions clearer and behavior frustrations easier to resolve. Parenting wisdom to help your dog move beyond trauma and into wellness. Borrowing the principles of parenting for dogs feels obvious to some people: instinctive and ordinary and inevitable. But that’s not true for everyone, especially those of us who had a less than ideal childhood and bear the scars of early harm, loss, trauma, or deprivation. Tender Paws provides an interdisciplinary, comprehensive, evidence-based guide for readers who want to honor the needs of—and improve outcomes for—puppies and dogs they care about.

The instant New York Times bestseller By the acclaimed author of In the Realm of Hungry Ghosts, a groundbreaking investigation into the causes of illness, a bracing critique of how our society breeds disease, and a pathway to health and healing. In this revolutionary book, renowned physician Gabor Maté eloquently dissects how in Western countries that pride themselves on their healthcare systems, chronic illness and general ill health are on the rise. Nearly 70 percent of Americans are on at least one prescription drug; more than half take two. In Canada, every fifth person has high blood pressure. In Europe, hypertension is diagnosed in more than 30 percent of the population. And everywhere, adolescent mental illness is on the rise. So what is really “normal” when it comes to health? Over four decades of clinical experience, Maté has come to recognize the prevailing understanding of “normal” as false, neglecting the roles that trauma and stress, and the pressures of modern-day living, exert on our bodies and our minds at the expense of good health. For all our expertise and technological sophistication, Western medicine often fails to treat the whole person, ignoring how today’s culture stresses the body, burdens the immune system, and undermines emotional balance. Now Maté brings his perspective to the great untangling of common myths about what makes us sick, connects the dots between the maladies of individuals and the declining soundness of society—and offers a compassionate guide for health and healing. Cowritten with his son Daniel, The Myth Of Normal is Maté’s most ambitious and urgent book yet.