Diagnosis And Management Of Polycystic Ovary Syndrome

Diagnosis and Management of Polycystic Ovary Syndrome is a comprehensive clinical reference work for primary care physicians, internists, general endocrinologists, obstetricians, gynecologists and students. PCOS is a common but frequently misdiagnosed disease. Many symptoms can be alleviated by early intervention and effective management. Prominent endocrinologists are gathered to detail current research and treatment in this metabolic disorder, affecting a growing population. The chapters are comprehensive, providing cutting edge knowledge on pathogenesis, manifestations, diagnosis and treatment of PCOS. Each chapter will be concise concluding with cogent practice points. The variety of medical issues presenting in PCOS patients result in late referrals or in- appropriate advice. This title will be a tool in a further understanding of the metabolic and genetic basis of PCOS, while providing management strategies.

Diagnosis and Management of Polycystic Ovary Syndrome is a comprehensive clinical reference work for primary care physicians, internists, general endocrinologists, obstetricians, gynecologists and students. PCOS is a common but frequently misdiagnosed disease. Many symptoms can be alleviated by early intervention and effective management. Prominent endocrinologists are gathered to detail current research and treatment in this metabolic disorder, affecting a growing population. The chapters are comprehensive, providing cutting edge knowledge on pathogenesis, manifestations, diagnosis and treatment of PCOS. Each chapter will be concise concluding with cogent practice points. The variety of medical issues presenting in PCOS patients result in late referrals or in- appropriate advice. This title will be a tool in a further understanding of the metabolic and genetic basis of PCOS, while providing management strategies.

"This work contains three chapters, each examining the hormonal imbalance disease polycystic ovary syndrome (PCOS) from a different perspective. Chapter 1 describes various characteristics of PCOS and reviews recent approaches for treatment strategies, including antioxidant supplementation, anti-inflammatory agents, and lifestyle modification. Chapter 2 reviews possible health risks and complications of PCOS. Finally, Chapter 3 aims to provide an understanding and wider concept of pathogenesis and intricacy of various pathways pertaining to the heterogeneity of this syndrome that can help to comprehend the disease's progression in detail"--

This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.

Women's healthcare regarding polycystic ovarian syndrome remains challenging. Patients often go from one specialist to another trying to fully understand and management the disorder. Women often go years before a diagnosis, seeing three or more doctors before a confirmed diagnosis. Polycystic Ovarian Syndrome: Challenging Issues in the Modern Era of Individualized Medicine brings together multiple medical disciplines to improve the care of women with PCOS. Such a multidisciplinary clinical and scientific approach integrates obstetrics and gynecology, pediatric and medical endocrinology, internal medicine, genetics, psychology and laboratory medicine into relevant translational clinical and scientific discussions that update both the scientific understanding of PCOS and the diagnosis and management of all aspects of the syndrome. The impact of PCO on the onset of puberty is subdivided in sub sections to get a better understanding of this condition and the management at different stages in a woman's life. Represents an unparalleled compilation of chapters from experts in the field relevant to contemporary polycystic ovarian syndrome Covers aspects such as obesity, metabolic changes, and emotional changes associated with PCOS Highlights contemporary management and the current understanding of this unique syndrome with a comprehensive and fresh approach

This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine

Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Clearly presented and thoroughly up to date, this important text provides an overview of current knowledge of the polycystic ovary syndrome (PCOS) - its etiology, pathology, and the implications for effective medical management. In contrast with existing titles, this book focuses on the difficulty in making an accurate diagnosis and the conseq

Purpose: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that afflicts about 4-12% of women of reproductive age. First discovered by Stein and Leventhal in 1935, it is currently defined by the National Institute of Health as oligo- or anovulation with features of hyperandrogenism, when all other possible causes of menstrual irregularity and hyperandrogenism have been ruled out. PCOS can be distressing to women due to infertility issues and hyperandrogenism symptoms. PCOS can be challenging to diagnose by clinicians, and even more difficult to manage due to the large amount of presentations and treatment options. Currently there is no standard or universal course of therapy available. Methods: An exhaustive literature search using the following search engines: Medline, NEJM, PudMed and CINAHL was conducted. Articles related to the topic but published more than 10 years ago were excluded. Results: PCOS therapy should be appropriate for each patient taking into consideration her fertility, health and cosmetic desires. All PCOS patients should first be treated with lifestyle changes as this can yield improvement in all areas of pathogenesis. Diet, exercise and weight loss has proved efficacious in restoring ovulation, improving hyperandrogenism and decreasing insulin resistance. Management of anovulation and infertility will depend on whether or not the patient is attempting to conceive. If not, then oral contraceptives to decrease the risk of endometrial carcinoma will be the appropriate choice. If the individual is trying to conceive, then clomiphene citrate is considered first line in order to restore ovulation and promote fertility. If the patient is clomiphene resistant then, metformin should be tried as it has shown to improve ovulation although not as well as clomiphene. The next options include laparoscopic ovarian diathermy or gonadotropin therapy. When treating symptoms of hyperandrogenism such as: hirsutism, acne, seborrhea and male pattern baldness, anti-androgens should be used in all patients not attempting to conceive in order to reduce the amount of systemic testosterone causing the symptoms. Specifically, hirsutism is generally treated with mechanical methods. Metformin has also been shown to help improve hirsutism. Acne can be treated with topical and oral antibiotics and seborrhea can be managed with steroid creams. Rogaine should be used in women with male pattern baldness. Finally, and most importantly, women with PCOS should always be screened and treated for insulin resistance and syndrome X to prevent and slow the progression of diabetic and cardiovascular complications. If insulin resistance is found, patients should be put on metformin or TZDs to increase insulin sensitization. Also, if other disorders associated with metabolic syndrome are present, such as hyperlipidemia or hypertension, they should be treated appropriately. Conclusion: If women with PCOS are diagnosed and managed properly with lifestyle changes and other pharmacological and surgical therapy, most distressing symptoms can be alleviated and future complications of diabetes and cardiovascular events can be slowed or prevented.

Now in a completely newly revised and expanded second edition, this comprehensive text presents the current state of the art in our understanding and management of polycystic ovary syndrome (PCOS), the most common hormonal disorder of reproductive aged women. The numerous bothersome symptoms of PCOS include menstrual irregularities, hirsutism, acne, scalp hair thinning, weigh excess and infertility; additionally, as they age, women with PCOS are at a higher risk for metabolic abnormalities such as diabetes and dyslipidemias, as well as for cardiovascular disease and even certain cancers. Despite improvements in our understanding of this condition, the exact cause/s of PCOS remain elusive; genetic, hormonal, metabolic and environmental underpinnings are all suggested as relevant. All chapters have been updated, with eight new chapters added across seven thematic sections. Part one discusses the epidemiology of PCOS in both adults and adolescents. Part two covers the pathophysiology of PCOS, including genetics, the hypothalamo-pituitary-ovarian and the hypothalamo-pituitary-adrenal axes, insulin resistance, inflammation, and obesity. The next three sections present the various management strategies, medical and surgical, for harnessing the symptomatology, including PCOS-related infertility; these chapters include added case material to provide real-world examples of the treatments in action and their efficacy. Part six covers the comorbidities that women with PCOS commonly encounter, such as issues of mental health, sleep disturbances, endometrial hyperplasia, and cancer, as well as examines the economic burden of PCOS. The final section discusses emerging concepts surrounding possible mechanisms and potential therapeutic approaches to PCOS, including angiogenic dysfunction, the role of vitamin D, future potential therapies to targeted AMH signaling. The closing chapter, by familiarizing the readers with the intergenerational implications of PCOS and by raising awareness of potential “ripple effects”, aims at alerting the community on a need for vigilance as regards the health of PCOS progeny. With contributions from leaders in the field, Polycystic Ovary Syndrome, Second Edition remains the gold-standard text on this common medical condition and a valuable resource for the wide range of healthcare professionals engaged in caring for the women with PCOS (including but not limited to reproductive endocrinologists, gynecologists, family physicians, dermatologists, mental health professionals), for the aspiring women's health providers of tomorrow, and for the researchers who are striving to unravel the mysteries of the complex entity that PCOS is.