Dendrimer Chemistry

An overview of the latest advances in the synthesis, characterization and applications of dendrimers and other complex dendritic architectures.

The unique structures and properties of dendrimers make them attractive for many applications, from drug delivery and antimicrobial agents to catalysis and as functional materials. Dendrimer Chemistry provides an overview of the latest advances in the synthesis of dendrimers and other complex dendritic architectures. The book focuses on established building block families for generating dendritic macromolecules, capitalizing on the evolution in the synthesis of dendrimers and other complex dendritic architectures. Systems covered range from dendritic polyesters and naturally occurring monomers to novel dendritic families. Each chapter starts with an introduction to the dendrimer family and its important features followed by information on the building blocks used to generate the dendrimers, their synthetic strategies and the resulting architectures. Chapters also cover the characterization and structural analysis, commercial availability and cutting-edge applications. Including forewords from leaders in the field, this will be a useful reference for postgraduate students and researchers in organic chemistry, polymer chemistry, materials science and macromolecular chemistry.

Written by internationally acclaimed authors, this textbook contains everything you need to know about this versatile class of compounds. Starting with a historical overview, definitions and other fundamentals, it goes on to look at characterization, analysis and properties of dendrimers. While the focus is on synthesis and applications, it also contains chapters on analytics and other applications. Essential reading for organic and polymer chemists, undergraduate and graduate students, students and lecturers in chemistry.

The second volume on dendrimers is again written by pioneers in the field. Their contributions illuminate the aspects of dendrimers mentioned in the subtitle, and also touch on areas beyond chemistry, namely material sciences as well as biological, medicinal, analytical, and nano aspects.

Following the first two volumes "Dendrimers" (TCC vol. 197) and "Dendrimers II" (TCC vol. 210), the third volume dealing with this topic is now appearing in print (the "tetralogy" on dendrimers will soon be completed with the fourth volume). The present volume comprises a collection of up-to-date reviews written by renowned pioneers of research in the dendrimer field, three of whom lectured at the 1. International Dendrimer Symposium (IDS-1 1999) in Frankfurt. A focus of this volume is the variety of material properties of soft and shape-persistent dendrimers. As its predecessors did, this volume breaks through the frontiers to neighboring disciplines and, in an interdisciplinary approach, addresses topics such as polydisperse, hyperbranched macromolecules (dendritic polymers), the analysis of shape and density by small-angle scattering techniques, finely dispersed metals (dendrimers as catalysts), and nanotechnology close to potential applications.

With contributions from many of the world's leading scientists in the field of dendritic research and development, Dendrimers and Other Dendritic Polymers provides a comprehensive review of this rapidly expanding and exciting new field of polymer science. Of interest to academia and industry alike, this book covers the synthesis, characterization, unique properties, potential for novel applications and technical challenges associated with these polymers. * Detailed coverage of all known subclasses of dendritic polymers, including their properties and synthesis * Insight into the potential commercial applications of dendritic polymers, including drug delivery, cancer therapy, coatings and adhesives * Identification of the key trends and perspectives in dendrimer research * Essential reference for polymer chemists, materials scientists and plastics engineers working in academia and industry alike

Dendrimers are a class of highly branched molecules that combine the properties of polymers and small discrete molecules. One classified among the exotic molecules of chemistry, dendrimers have attracted considerable attention in recent years, as their unique host/guest properties and their capability of being functionalized in the periphery as well in the core have led to new materials with a great potential for applications. This volume presents the state of art in this blossoming area, written by pioneers in the fields. Covering the synthetic, supramolecular, stereochemical, host/guest and polymer chemistry of dendritic and hyperbranched molecules, this volume explains both theoretical and practical aspects, including chirality reactivity, mechanism, material properties and biological relevance.

Dendrimer science has exploded onto the polymer science scene as the fourth major class of polymer architecture. Capturing the history of dendrimer discovery to the present day, this book addresses all the essential information for newcomers and those experienced in the field, including: • Fundamental theory, chemistry and physics of the 'dendritic state' • Synthetic strategies (click chemistry, self-assembly, and so on) • Dendron/dendrimer characterization techniques • Architecturally driven 'dendritic effects' • Developments in scientific and commercial applications • Convergence with nanotechnology, including dendrimer-based nanodevices, nanomaterials, nanotoxicology and nanomedicine • Dendrimers as a window to a new nano-periodic system. Including first-hand accounts from pre-1995 pioneers, progress in the dendrimer field is brought to life with anticipated developments for the future. This is the ideal book for researchers in both academia and industry who need a complete introduction to the 'dendritic state' with a special focus on dendrimer and dendron polymer science.

The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.

Dendrimers, hyperbranched macromolecules, emerged just few decades ago but show promising potential as drug delivery nanocarriers, theranostic agents and gene vectors; in the pharmaceutical research and innovation area as well as in other healthcare applications. Although tremendous advancements have been made in dendrimer chemistry and their applications since their emergence, the synthesis, development and design of pure and safe dendrimer-based products have been a major challenge in this area. This book, edited by well-known researchers in the area of nanomaterials and drug-based drug delivery applications, exhaustively covers the nanotechnological aspects, concepts, properties, characterisation, application, biofate and regulatory aspects of dendrimers. It includes sixteen vivid chapters by renowned formulators, researchers and academicians from all over the world, highlighting their specialised areas of interest in the fields of chemistry, biology, pharmacy and nanomedicine. Features: • Highlights dendrimers’ advancements in nanomedicine in the development of safe healthcare and biotechnological products • Covers physicochemical aspects, biofate, drug delivery aspects and gene therapy using dendrimers • Covers biomedical application of dendrimers in the field of biological sciences • Gives examples of dendrimer–guest interaction chemistry Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives provides the comprehensive overview of the latest research efforts in designing, optimising, development and scale-up of dendrimer-mediated delivery systems. It analyses the key challenges of synthesis, design, molecular modelling, fundamental concepts, drug delivery aspects, analytical tools and biological fate as well as regulatory consideration to the practical use of dendrimer application. Dr. Neelesh Kumar Mehra Assistant Professor of Pharmaceutics in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He has authored more than sixty peer-reviewed publications in highly reputed international journals, as well as book chapters and contributions on two patents. Dr. Mehra has 11 years of rich research and teaching experience in the formulation and development of complex, innovative biopharmaceutical products including micro- and nanotechnologies for regulated markets. Dr. Keerti Jain Assistant Professor of Pharmaceutics in the Department of Pharmaceutics, NIPER, Raebareli, India. For more than 10 years, she has been actively engaged in formulation and development of nanomedicines. Dr. Jain has supervised masters and doctoral pharmaceutics students in their research works which have been published in high quality, good impact factor journals. She has also authored more than 60 international manuscripts in peer reviewed high impact journals. In 2019, she was awarded the prestigious ICMR-Amir Shakuntala Award.