Data Assimilation And Control Theory And Applications In Life Sciences

The understanding of complex systems is a key element to predict and control the system’s dynamics. To gain deeper insights into the underlying actions of complex systems today, more and more data of diverse types are analyzed that mirror the systems dynamics, whereas system models are still hard to derive. Data assimilation merges both data and model to an optimal description of complex systems’ dynamics. The present eBook brings together both recent theoretical work in data assimilation and control and demonstrates applications in diverse research fields.

Data assimilation is theoretically founded on probability, statistics, control theory, information theory, linear algebra, and functional analysis. At the same time, data assimilation is a very practical subject, given its goal of estimating the posterior probability density function in realistic high-dimensional applications. This puts data assimilation at the intersection between the contrasting requirements of theory and practice. Based on over twenty years of teaching courses in data assimilation, Principles of Data Assimilation introduces a unique perspective that is firmly based on mathematical theories, but also acknowledges practical limitations of the theory. With the inclusion of numerous examples and practical case studies throughout, this new perspective will help students and researchers to competently interpret data assimilation results and to identify critical challenges of developing data assimilation algorithms. The benefit of information theory also introduces new pathways for further development, understanding, and improvement of data assimilation methods.

Data assimilation is an approach that combines observations and model output, with the objective of improving the latter. This book places data assimilation into the broader context of inverse problems and the theory, methods, and algorithms that are used for their solution. It provides a framework for, and insight into, the inverse problem nature of data assimilation, emphasizing why and not just how. Methods and diagnostics are emphasized, enabling readers to readily apply them to their own field of study. Readers will find a comprehensive guide that is accessible to nonexperts; numerous examples and diverse applications from a broad range of domains, including geophysics and geophysical flows, environmental acoustics, medical imaging, mechanical and biomedical engineering, economics and finance, and traffic control and urban planning; and the latest methods for advanced data assimilation, combining variational and statistical approaches.

This book endeavours to give a concise contribution to understanding the data assimilation and related methodologies. The mathematical concepts and related algorithms are fully presented, especially for those facing this theme for the first time. The first chapter gives a wide overview of the data assimilation steps starting from Gauss' first methods to the most recent as those developed under the Monte Carlo methods. The second chapter treats the representation of the physical system as an ontological basis of the problem. The third chapter deals with the classical Kalman filter, while the fourth chapter deals with the advanced methods based on recursive Bayesian Estimation. A special chapter, the fifth, deals with the possible applications, from the first Lorenz model, passing trough the biology and medicine up to planetary assimilation, mainly on Mars. This book serves both teachers and college students, and other interested parties providing the algorithms and formulas to manage the data assimilation everywhere a dynamic system is present.

This monograph addresses the state of the art of reduced order methods for modeling and computational reduction of complex parametrized systems, governed by ordinary and/or partial differential equations, with a special emphasis on real time computing techniques and applications in computational mechanics, bioengineering and computer graphics. Several topics are covered, including: design, optimization, and control theory in real-time with applications in engineering; data assimilation, geometry registration, and parameter estimation with special attention to real-time computing in biomedical engineering and computational physics; real-time visualization of physics-based simulations in computer science; the treatment of high-dimensional problems in state space, physical space, or parameter space; the interactions between different model reduction and dimensionality reduction approaches; the development of general error estimation frameworks which take into account both model and discretization effects. This book is primarily addressed to computational scientists interested in computational reduction techniques for large scale differential problems.

Numerical Control: Part B, Volume 24 in the Handbook of Numerical Analysis series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include Control problems in the coefficients and the domain for linear elliptic equations, Computational approaches for extremal geometric eigenvalue problems, Non-overlapping domain decomposition in space and time for PDE-constrained optimal control problems on networks, Feedback Control of Time-dependent Nonlinear PDEs with Applications in Fluid Dynamics, Stabilization of the Navier-Stokes equations - Theoretical and numerical aspects, Reconstruction algorithms based on Carleman estimates, and more. Other sections cover Discrete time formulations as time discretization strategies in data assimilation, Back and forth iterations/Time reversal methods, Unbalanced Optimal Transport: from Theory to Numerics, An ADMM Approach to the Exact and Approximate Controllability of Parabolic Equations, Nonlocal balance laws -- an overview over recent results, Numerics and control of conservation laws, Numerical approaches for simulation and control of superconducting quantum circuits, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Handbook of Numerical Analysis series Updated release includes the latest information on Numerical Control

Data assimilation methods were largely developed for operational weather forecasting, but in recent years have been applied to an increasing range of earth science disciplines. This book will set out the theoretical basis of data assimilation with contributions by top international experts in the field. Various aspects of data assimilation are discussed including: theory; observations; models; numerical weather prediction; evaluation of observations and models; assessment of future satellite missions; application to components of the Earth System. References are made to recent developments in data assimilation theory (e.g. Ensemble Kalman filter), and to novel applications of the data assimilation method (e.g. ionosphere, Mars data assimilation).

This book is about the dynamics of neural systems and should be suitable for those with a background in mathematics, physics, or engineering who want to see how their knowledge and skill sets can be applied in a neurobiological context. No prior knowledge of neuroscience is assumed, nor is advanced understanding of all aspects of applied mathematics! Rather, models and methods are introduced in the context of a typical neural phenomenon and a narrative developed that will allow the reader to test their understanding by tackling a set of mathematical problems at the end of each chapter. The emphasis is on mathematical- as opposed to computational-neuroscience, though stresses calculation above theorem and proof. The book presents necessary mathematical material in a digestible and compact form when required for specific topics. The book has nine chapters, progressing from the cell to the tissue, and an extensive set of references. It includes Markov chain models for ions, differential equations for single neuron models, idealised phenomenological models, phase oscillator networks, spiking networks, and integro-differential equations for large scale brain activity, with delays and stochasticity thrown in for good measure. One common methodological element that arises throughout the book is the use of techniques from nonsmooth dynamical systems to form tractable models and make explicit progress in calculating solutions for rhythmic neural behaviour, synchrony, waves, patterns, and their stability. This book was written for those with an interest in applied mathematics seeking to expand their horizons to cover the dynamics of neural systems. It is suitable for a Masters level course or for postgraduate researchers starting in the field of mathematical neuroscience.

Data assimilation methods were largely developed for operational weather forecasting, but in recent years have been applied to an increasing range of earth science disciplines. This book will set out the theoretical basis of data assimilation with contributions by top international experts in the field. Various aspects of data assimilation are discussed including: theory; observations; models; numerical weather prediction; evaluation of observations and models; assessment of future satellite missions; application to components of the Earth System. References are made to recent developments in data assimilation theory (e.g. Ensemble Kalman filter), and to novel applications of the data assimilation method (e.g. ionosphere, Mars data assimilation).