Current Trends In Bone Grafting

Bone grafting is an essential technique in bone and joint surgery. This book covers the different types of graft, especially the viable ones created with microvascular anastomoses. Both conventional techniques and newer methods are included, with emphasis on the latter. New approaches are highlighted in the application of vascularised bone grafts in post-resection bony reconstruction and of vascularised composite bone grafts in hand reconstruction. With increased awareness of the advantages of bone grafts, surgeons will more readily recognize indications and identify areas of application.

This valuable book presents clinical experiences and research of bone grafting. Bone grafting is an essential technique practiced by craniofacial, maxillofacial, orthopedic, neuro, reconstructive and oral surgeons. Bone grafting can be used for reconstruction and restoring missing bone in trauma and tumor surgery of the facial bone or in road traffic accidents with multiple injuries and in post-traumatic missile war injuries to the face or limbs. Bone grafts, in the form of Kummoona Chondro-Ossous graft or Costo-Chondral graft, are used for reconstruction of damage TMJ for restoration of growth, function, and repair. Bone grafting is a surgical procedure where the iliac crest or rib or tibia is used to perform grafting. In this book, we examine the experimental studies on rabbits to understand the cellular changes associated with bone grafting. From this, we noticed that mesenchymal stem cells and growth factor are released from platelets and these play an important role in healing the bone graft. We recommend this valuable book to all cranio-maxillofacial, orthopedic, plastic, reconstructive, neuro and oral surgeons and to all postgraduate students studying bone grafting.

This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions.

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

This book describes all methods of bone management currently employed within the field of dental implantology, with the aim of equipping oral surgeons and other practitioners with a sound practical understanding of bone augmentation. The different possibilities for augmentation of the jaw in the vertical and horizontal dimensions are explained, and detailed information provided on the latest techniques of augmentation, including guided bone regeneration, mandibular bone grafting, 3D technique, extraoral bone augmentation, and microvascular bone transplantation. Readers will find clear guidance on diagnosis and treatment planning and helpful discussion of the basic principles of bone augmentation. Individual chapters also address the role of lasers, complications and risks, and emerging trends. The extensive case documentation, with numerous color illustrations and photos, highlights what is possible today in the field of bone regeneration. This book is a “must read” for all implantologists, oral maxillofacial surgeons, periodontists, and dentists with an interest in oral surgery.

Autogenous bone grafting continues to be the gold standard for treating osseous defects and stimulating new bone formation. Harvesting of autogenous bone grafts can be associated with a significant risk of complications. Also, the amount of bone graft that can be harvested is limited. Therefore, efforts have been made to develop different bone graft substitutes such as: allografts, synthetic bone substitutes, platelet-rich plasma, bone marrow aspirate, Bone Morphogenetic Proteins, Vascular Endothelial Growth Factor, Fibroblast Growth Factors, parathyroid hormone and Wnt signalling. Some techniques with the use of bone autografts in orthopaedics and dentistry, complications associated with the harvest of autografts, the use of other alternatives, their biology and clinical applications and a look into research into new materials and technologies aiming to improve this field in medicine will be discussed in this book.

Tissue Engineering and Regeneration in Dentistry: Current Strategies presents a thorough update on the current advances, methods and understanding in tissue engineering in dentistry. It offers invaluable tools, case studies, and methodologies for undertaking research, including important biological and practical considerations to facilitate successful migration of research from the bench to the clinic. Offers detailed coverage of the basic underlying principles and scientific evidence, and includes protocols to highlight practical applications Written by an internationally renowned team of expert contributors A must-have read for researchers and specialist clinicians in tissue engineering, oral biology, dental materials science, periodontology and oral surgery