Contribution Of Pax1 To Pathogenesis Of Adolescent Idiopathic Scoliosis

This book outlines knowledge and hypotheses of the causation of adolescent idiopathic scoliosis (AIS). It begins with Sevastik and Stokes addressing terminology. It includes the epidemiology and demography of adolescent idiopathic scoliosis, the role of genetic factors, hypothesis of causation, osteopenia, Hueter-Votkmann effect, and the role of the intervertebral disc. It analyzes the structure and composition of the cartilage end plate and intervertebral disc, the significance of the sternum, the thoracospinal concept of etiopathogenesis of adolescent scoliosis, and the skeletal growth.

This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. The book is written by leaders in genetic and developmental research on scoliosis and developmental studies of the spine.

Orthopaedic Knowledge Update®: Pediatrics 6 reflects the most recent clinical practice guidelines and appropriate use criteria, as well as the substantial number of high-quality studies in pediatric orthopaedics. This comprehensive multispecialty resource explores the latest advances in pediatric trauma, sports-related injuries, and upper and lower extremity conditions, with brand-new chapters on developmental biology, metabolism, high-energy injury and polytrauma, elbow trauma, knee trauma, and disaster response. Recognized section editors and contributors bring fresh approaches and perspectives, with a focus on delivering a well-rounded update of this rapidly evolving subspecialty. This concentrated guide to new techniques, new approaches, and current controversies is ideal for anyone who treats pediatric musculoskeletal injuries.

OKU: Pediatrics 5 reflects the substantial number of high-quality studies in pediatric orthopaedics, as well as the most recent clinical practice guidelines and appropriate use criteria. This comprehensive multispecialty resource explores the latest advances in pediatric trauma, sports-related injuries, and upper and lower extremity conditions, with a brand-new section on Neuromuscular, Metabolic, and Inflammatory Disorders.

This book provides cutting-edge studies and technologies using small fishes, including zebrafish, medaka, and other fishes as new model animals for molecular biology, developmental biology, and medicine. It also introduces eccentric fish models that are pioneering new frontiers of biology. Zebrafish and medaka have been developed as lower vertebrate model organisms because these small fish are easy to raise in the laboratory and are useful for the live imaging of the morphology and activity of cells and tissues in intact animals. By virtue of those specific advantages, fish studies have demonstrated the common features of vertebrates and raised further questions toward understanding the mystery of life. The book consists of four parts: “Development and Cell Biology”, “Homeostasis and Reproduction”, “Clinical Models”, and “Eccentric Fish”. Together they describes the core area of small fish study – often considered mere zoology but which is actually proving to be the universal basis of life. Written by leading scientists, the book helps readers to understand small fishes, inspires scientists to utilize small fishes in their studies, and encourages anyone who wants to participate in the large and fantastic world of small fish.

It is over 70 years since two orthopedic surgeons invented the Milwaukee brace for the treatment of children with scoliosis. Since then, clinicians and researchers have been inspired to design ever more effective braces to correct 3-D spinal deformities. This book presents papers from the bi-annual meeting of the International Research Society of Spinal Deformities (IRSSD), held as a virtual event on 22 and 23 January 2021. The IRSSD concentrates on research into spinal deformity with clinical applications. In addition to 3D assessment of the spine, researchers also explore spinal biomechanics, etiopathogenesis, and innovative conservative and surgical therapies with the goal of integrating science with clinical care to improve patient care. The 2021 meeting was originally scheduled to take place in Milwaukee, Wisconsin, USA, but was instead held in a virtual format due to the Covid 19 pandemic. Despite this change, the meeting still allowed valuable interaction and open discussion among practitioners from around the world, and keynote speakers and authors contributed the 44 short papers and 47 abstracts included here. The papers are grouped under 17 chapter headings, and cover a wide range of topics, including biologic and biomechanical benchmarks, clinical evaluation, conservative treatments and surgical approaches. Diagnostic assessments and non-surgical treatments of EOS are also emphasized and elucidated. The book will be of interest to all those whose work is related to the treatment and care of patients with spinal deformities.

Spinal disorders in very young children may be caused by a variety of conditions. The treatment of such conditions is often challenging due to the age of the patient and the progressive nature of the deformity. There also may be associated problems such as congenital anomalies, respiratory insufficiency, and neurological problems. Depending on the etiology of the deformity, these children are often cared for by multiple specialists including pediatricians, pediatric orthopaedists or orthopaedic spine surgeons, neurologists, pediatric surgeons, pediatric neurosurgeons, oncologists, and/or pulmonologists. Health professionals in all of the mentioned disciplines are involved in the management of these patients, which is why compiling a comprehensive textbook that is not limited to orthopedic specialists is essential. This textbook will effectively help to standardize the care of these patients. Furthermore, other professionals such as nurses, physical therapists and healthcare professionals in training are usually not familiar with these conditions and are in need of a reference book to consult when caring for children with spinal deformities.

The must-have book for candidates preparing for the oral component of the FRCS (Tr and Orth).