Chiral Catalyst Immobilization And Recycling

Homogeneous asymmetric catalysis offers reliable results and the possibility to 'tune' the catalysis on a rational basis. A pitfall, however, is that the separation of the catalyst from the starting material and products is difficult and often results in the loss of the catalytic material. Immobilization offers a potential solution for the user of enantioselective catalysts in industrial processes and laboratories. Heterogeneous catalysis allows continuous operations, recycling of the catalyst, and an easy separation of the reaction products, reducing both waste and costs. Chemists in academia and industry will welcome this careful selection of topics in this handbook that provides readers with practical and detailed information about the technical requirements for the immobilization of chiral catalysts, their application in synthesis, and methods for recycling.

A comprehensive resource on techniques and applications for immobilizing catalysts Catalyst Immobilization: Methods and Applications covers catalyst immobilization topics including technologies, materials, characterization, chemical activity, and recyclability. The book also presents innovative applications for supported catalysts, such as flow chemistry and machine-assisted organic synthesis. Written by an international panel of expert contributors, this book outlines the general principles of catalyst immobilization and explores different types of supports employed in catalyst heterogenization. The book?s chapters examine the immobilization of chiral organocatalysts, reactions in flow reactors, 3D printed devices for catalytic systems, and more. Catalyst Immobilization offers a modern vision and a broad and critical view of this exciting field. This important book: -Offers a guide to supported and therefore recyclable catalysts, which is one of the most important tools for developing a highly sustainable chemistry -Presents various immobilization techniques and applications -Explores new trends, such as 3D printed devices for catalytic systems -Contains information from a leading international team of authors Written for catalytic chemists, organic chemists, process engineers, biochemists, surface chemists, materials scientists, analytical chemists, Catalyst Immobilization: Methods and Applications presents the latest developments and includes a review of the innovative trends such as flow chemistry, reactions in microreactors, and beyond.

Recoverable and Recyclable Catalysts There is continued pressure on chemical and pharmaceutical industries to reduce chemical waste and improve the selectivity and efficiency of synthetic processes. The need to implement green chemistry principles is a driving force towards the development of recoverable and recyclable catalysts. The design and synthesis of recoverable catalysts is a highly challenging interdisciplinary field combining chemistry, materials science engineering with economic and environmental objectives. Drawing on international research and highlighting recent developments, this book serves as a practical guide for both experts and newcomers to the field. Topics covered include: An introduction to the principles of catalyst recovery and recycling Catalysts on insoluble and soluble support materials Thermomorphic catalysts, self-supported catalysts and perfluorous catalytic systems The development of reusable organic catalysts Continuous flow and membrane reactors Each chapter combines principles with practical information on the synthesis of catalysts and strategies for catalyst recovery. The book concludes with a comparison of different catalytic systems, using case studies to illustrate the key features of each approach. Recoverable and Recyclable Catalysts is a valuable reference source for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those working in catalysis, organic synthesis and sustainable chemistry.

In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.

R. Haag, S. Roller: Polymeric Supports for the Immobilisation of Catalysts .- J. Horn, F. Michalek, C.C. Tzschucke, W. Bannwarth: Non-Covalently Solid-Phase Bound Catalysts for Organic Synthesis .- Y. Uozumi: Recent Progress in Polymeric Palladium Catalysts for Organic Synthesis .- D.E. Bergbreiter, J. Li: Applications of Catalysts on Soluble Supports .- B. Desai, C.O. Kappe: Microwave-Assisted Synthesis Involving Immobilized Catalysts .- A. Kirschning, G. Jas: Applications of Immobilized Catalysts in Continuous Flow Processes .- N. End, K.-U. Schöning: Immobilized Catalysts in Industrial Research and Application .- N. End, K.-U. Schöning: Immobilized Biocatalysts in Industrial Research and Production

Immobilization of chiral catalysts is an important tool for improving overall efficiency of catalytic processes. However, heterogeneous catalysts often suffer from decreased activities and supported but still homogeneous catalysts can help overcome this issue. This book covers the most important concepts of homogeneous supported catalysis with an emphasis on enantioselective processes. It describes the state-of-the-art and latest developments in each area whilst critically evaluating the strengths and weaknesses of this important method. The book encompasses ionically-tagged catalysts, supported organocatalysts, supported ionic liquid phases, catalysis using soluble polymers, catalytic dendrimers, fluorous catalysts, water soluble catalysts and non-covalent immobilization methods. Potential developments and ideas for the future are also highlighted. There is a growing demand for effective and recyclable catalysts so this book, covering all the important methods in the field of supported homogeneous catalysis, will appeal to many researchers in academia and industry.

This book looks at new ways of tackling the problem of separating reaction products from homogeneous catalytic solutions. The new processes involve low leaching supported catalysts, soluble supports such as polymers and dendrimers and unusual solvents such as water, fluorinated organics, ionic liquids and supercritical fluids. The advantages of the different possibilities are discussed alongside suggestions for further research that will be required for commercialisation. Unlike other books, in addition to the chemistry involved, the book looks at the process design that would be required to bring the new approaches to fruition. Comparisons are given with existing processes that have already been successfully applied and examples are given where these approaches are not suitable. The book includes: - New processes for the separation of products from solutions containing homogeneous catalysts - Catalysts on insoluble or soluble supports – fixed bed catalysts - continuous flow or ultrafiltration - Biphasic systems: water - organic, fluorous - organic, ionic liquid – organic, supercritical fluids (monophasic or biphasic with water, organic or ionic liquid) - Comparisons with current processes involving atmospheric or low temperature distillation - Consideration of Chemistry and Process Design - Advantages and disadvantages of each process exposed - Consideration of what else is need for commercialisation

The work embodied in this book comprises of brief introduction of chiral homogeneous and heterogeneous asymmetric catalysis. Research work presented in this book presents synthesis and physicochemical characterization of mesoporous materials MCM-41 and SBA-15 and used them as supports for immobilization of chiral BINOL, immobilization of chiral BINOL on mesoporous materials SBA-15 and MCF of relatively large pore size and used as active catalysts for asymmetric diethylzinc addition to aldehydes, synthesis of chiral recyclable salen based metal complexes, new chiral polymeric Zn(salen) catalyst and used as a heterogeneous catalyst in asymmetric phenylacetylene addition to carbonyls, synthesis of chiral dimeric and polymeric Mn(III) salen complexes respectively. These complexes were used as recyclable catalysts in oxidative kinetic resolution of racemic secondary alcohols.

This book reviews chiral polymer synthesis and its application to asymmetric catalysis. It features the design and use of polymer-immobilized catalysts and methods for their design and synthesis. Chapters cover peptide-catalyzed and enantioselective synthesis, optically-active polymers, and continuous flow processes. It collects recent advances in an important field of polymer and organic chemistry, with leading researchers explaining applications in academic and industry R & D.

In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.