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China has become a leading source of international college students for Western countries, including the USA, the UK, Australia, New Zealand, and Canada. Given Chinese students' increasingly large contribution to the college population and financial import (tuition, travel expenses, other expenses, etc.) to the host countries, their specific needs in community services such as mental health and counseling should be addressed. Studies across different countries have explored the challenges associated with overseas experiences. These studies indicate that international college students, relative to domestic students, face higher levels of stress given the additional acculturative challenges. Research has further shown that Chinese international students reported high levels of psychological distress (depression, anxiety, stress). However, there is little research either investigating the measurement of unique stressors experienced by Chinese International Students or developing culturally sensitive interventions for their stress management. In the current two-part study, we aimed to, first, identify unique stressors of Chinese international students in the United States; and second, further design a culturally relevant Acceptance and Commitment Therapy intervention focused on helping Chinese international students manage the transition from their home country to the United States. Additionally, we ran a pilot study (randomized clinical trial) to examine the effectiveness of this intervention. Focus groups results revealed ten major domains of acculturative stress experienced by Chinese International Students. An acculturative stress measure, the Unique Stress of Chinese International Students (USCIS), was developed from the focus groups. The USCIS contains 103 items and demonstrated excellent internal consistency and convergent validity based on a sample of 30 Chinese International Students. Results of the pilot study based on a sample of 8 participants showed preliminary effectiveness of ACT in reducing depression, anxiety, stress, and acculturative stress reported by Chinese international Students.