Carbon Carbon Bond Formation

Volume 3 covers carbon-to-carbon single bond forming reactions involving sp3, sp2 and sp carbon centers, but only those which do not involve additions to C-X &pgr;-bonds. The volume first compares and contrasts the alkylation reactions of all types of sp3 carbon nucleophiles and also covers vinyl and alkynyl carbanions. Following on from Volume 2, a separate section covers Friedel-Crafts alkylation reactions, which is complemented by discussions of polyene cyclizations and electrophilic transannular cyclizations in synthesis. Coupling reactions leading to &agr;-bond formation, and involving all types of combinations ofsp3, sp2 and sp carbon centers are next covered, including those reactions based on pinacol, acyloin and phenol oxidative coupling reactions, and also the Kolbe reaction. Rearrangement reactions, leading to carbon-to-carbon &agr;-bond formation, are often used in a clever manner in synthesis. The volume includes all those rearrangement reactions based on intermediate carbonium ions and carbanions, and also includes the benzil-benzilic acid and the Wolff rearrangements. The volume closes with coverage of carbonylation reactions, and the use of carbene insertion reactions into the C-H bond in synthesis.

Textbook on modern methods of organic synthesis.

TheprototypicalcatalyticreductiveC-Cbondformations,theFischer-Tropsch reaction [1] and alkene hydroformylation [2], were discovered in 1922 and 1938, respectively [3,4]. These processes, which involve reductive coupling to carbon monoxide, have long been applied to the industrial manufacture of commodity chemicals [5]. Notably, alkene hydroformylation, also known as the oxo-synthesis, has emerged as the largest volume application of homo- neous metal catalysis, accounting for the production of over 7 million metric tons of aldehyde annually. Despite the impact of these prototypical reductive C-C bond formations, this ?eld of research lay fallow for several decades. Eventually, the increased availability of mild terminal reductants, in part- ular silanes, led to a renaissance in the area of catalytic reductive C-C bond formation.Forexample,the'rstcatalyticreductiveC-Ccouplingsbeyond- droformylation, which involve the hydrosilylative dimerization of conjugated dienes [6-12], appeared in 1969 - approximately 16 years after the ?rst - ported metal-catalyzed alkene hydrosilylation [13]. Following these seminal studies, the ?eld of catalytic reductive C-C bond formation underwent exp- sivegrowth,culminatingintheemergenceofanevergrowingbodyofresearch encompassing a powerful set of transformations. To our knowledge, no thematic volumes devoted solely to metal-catalyzed reductive C-C bond formationhave been assembled. For the ?rst time, in this issue of Topics in Current Chemistry,wepresent acompilation ofmonographs from several leaders in this burgeoning area of research. This collection of reviews serves to capture the diversity of catalytic reductive C-C couplings presently available and, in turn, the remarkable range of reactivity embodied by such transformations. There is no indication that this ?eld has reached its zenithanditisthehopeofthepresentauthorthatthisvolumewillfuelfurther progress.

Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.

This is the third volume in the series edited by Frank Hartley on The Chemistry of the Metal Carbon Bond. The series is concerned with organometallic compounds from the point of view of the carbon end of the bond and is, therefore, relevant to Organic Chemists. This particular volume is concerned with Carbon-Carbon bonds and their formation using organometallic compounds.

Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.