Biomatrix

Biomatrix: A Systems Approach to Organisational and Societal Change provides a comprehensive theory of management. It outlines how change in organisations and society needs to be managed in the information age: systemically. It also proposes ideas for new governance models. Part 1 of the book provides an overview of Biomatrix systems theory. Part 2 applies the theory to management, organisation development and transformation. Part 3 applies the theory to dissolving complex societal problems. The book may be regarded as a textbook for management, leadership and governance in the 21st century. Case studies are provided throughout.

The advantages of obtaining a completely defined environment for the growth of cells in vitro were recognized very early in the history of cell culture (Lewis and Lewis, 1911). Continued interest in the nutritional requirements of cells in vitro and in providing an optimal environment for cells led to the development of the complex nutrient mixtures available today in many media (Waymouth, 1972; Ham, 1965). However, serum remained an essential component of medium for the growth of most cell types in culture. The question of what factor (or factors) in serum was essential for cell growth and survival remained unanswered for several decades. Initially, experiments were designed to purify the "active component" of serum for the growth of cells in culture. These experiments identified fetuin (Fisher et at., 1958) and nonsuppressible insulinlike activity (Temin et at., 1972) as important components of serum. However, the complexity of serum and the very low levels of active components in serum hindered progress in identi fying and isolating serum factors.

INTERVENTIONAL CARDIOLOGY The updated guide to understanding and implementing today’s interventional cardiology procedures Minimally invasive methods of cardiovascular intervention are developing apace, propelled by unprecedented advancements in technology and procedural expertise. Bearing exciting implications for a broad range of adjacent fields of surgery and patient care, these innovative techniques are of ever-increasing importance, not only within cardiology, but across medicine as a whole. This third edition of Interventional Cardiology is designed to equip practitioners of all levels with a working knowledge of today’s best and most up-to-date practices, as well as the fundamental principles that underlie their use. Expertly revised to span coronary interventions, interventional pharmacology, structural heart interventions, endovascular therapy, and more, its modular sections are accompanied by multiple-choice questions to help aid learning and self-assessment. The new edition of Interventional Cardiology features: A thorough survey of the field, including atherogenesis and inflammation, vascular access controversies, radiation protection concepts, acute and chronic interventional pharmacology recommendations for high risk subjects/procedures Evaluations with imaging and physiology, including physiologic assessment in the cardiac catheterization lab, intravascular ultrasound, and optical coherence tomography Discussions of revascularization in various clinical settings, including stable coronary heart disease, acute myocardial infarction, he management of cardiogenic shock, and hemodynamic support devices and techniques Examinations of coronary interventions in various lesion types, including complex lesions, left main, bifurcations, CTO Heart valve disease and relevant percutaneous interventions, including preop imaging and clinical evaluations and outcomes assessment in great depth and with technical details; left atrial interventions are an expanding frontier Peripheral vascular, carotid and aorta/branch diseases are covered in greater detail than previous editions; venous disease treatments have become well established Accompanied by a companion website featuring videos illustrating key procedures and interactive multiple choice questions Whether studying for certification or already working in advanced practice, medical professionals of all kinds will benefit greatly from the practical instruction and cutting-edge knowledge found within this vital third edition.

From Gene to Protein: Translation into Biotechnology is the 15th volume in the continuing series under the title ""Miami Winter Symposia"". The theme of the symposium is the translation of the basic research findings into the practical application of biotechnology. This book summarizes methodology and its applications that lie behind the practical innovations. The book starts with reviews of techniques of eukaryotic cell culture, hybridoma technology and uses, and the in vitro synthesis of DNA and its use in the generation of protein analogs. Considerable space is devoted to development of monoclonal antibodies that promises to be the dominating tool of medical technology, both for diagnosis and therapy. Cloning into eukaryotic cells and methods of increasing the levels of gene expression are included. These topics reflect areas of intensive research that have important commercial and clinical value. Core chapters describe biological activities of cloned gene products, including reports on trials with human subjects of interferon, human insulin, and growth hormone. A panel session on horizons in biotechnology is also provided, looking forward to the directions of future research and its applications. Biotechnologists, cell biologists, scientists, researchers, teachers, and students will greatly benefit from this book.

This textbook is a readily accessible educational tool for all fellows undertaking subspecialty training in interventional cardiology, while also serving as a refresher to early career interventional cardiologists. The key objective is to equip the reader with an evidence-based expert-led resource focussed primarily on pre-procedural planning, peri-procedural decision-making, and the salient technical aspects of performing safe and effective coronary intervention, the intention being to support the therapeutic decision-making process in the emergency room, coronary care unit or cath lab in order to optimize patient outcome. The Interventional Cardiology Training Manual provides readers with a step-by-step guide to the basic principles underpinning coronary intervention and facilitates rapid access to best practice from the experts, presented in a pragmatic, digestible and concise format. Uniquely, each chapter has been written in a heart center-specific manner, affording the reader an opportunity to learn how individual institutions perform a specific procedure, which algorithms and guidelines they follow and what evidence they draw on to instigate the best possible care for their patients.

Myocardial tissue engineering (MTE), a concept that intends to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.

Now available as revised edition: The successful title on integrated ecological landscape planning Infrastructure, as we know it, no longer belongs in the exclusive realm of engineers and transportation planners. In the context of rapidly changing cities and towns, infrastructure is experiencing a paradigm shift where multiple-use programming and the integration of latent ecologies is a primary consideration. Defining contemporary infrastructure requires a multi-disciplinary team of landscape architects, engineers, architects and planners to fully realize the benefits to our cultural and natural systems. This book examines the potential of landscape as infrastructure via essays by notable authors and supporting case studies by SWA landscape architects and urban designers, among them the technologically innovative roof domes for Renzo Piano’s California Academy of Science in San Francisco, the restoration of the Buffalo Bayou in Houston, and several master plans for ecological corridors in China and Korea. Other projects develop smart re-use concepts for railroad tracks that no longer serve their original purpose, such as Kyung-Chun railway in Seoul or Katy Trail in Dallas. All case studies are described extensively with technical diagrams and plans for repositioning infrastructure as a viable medium for addressing issues of ecology, transit, urbanism, performance, and habitat.

This series was conceived with the idea of integrating current aspects of ongoing research in the collagen field. The book consists of a spectrum of papers which discus divers aspects such as X-ray structure, the thermodynamics and mechanism of fibrillogenesis, and the use of collagen as a biomaterial for the manufacturing of many implantable, sometimes lifesaving, devises.