Biological Diagnostic And Therapeutic Advances In Alzheimers Disease

This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.

Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the ‘amyloid’ or ‘tau’ hypotheses.This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Alzheimer's disease (AD) refers to a type of neurologic condition, which causes the brain to shrink and brain cells to die over time. AD is the most frequent form of dementia in which a progressive loss in social, cognitive and behavioral abilities occurs that impairs a person's capacity to operate independently. The primary symptom of AD is forgetting recent events or discussions. A person with AD will have severe memory impairment, while losing the capacity to perform daily tasks, as the disease progress. Drug development for AD relies heavily on biomarkers and they can also be used to facilitate diagnosis, safety monitoring, demonstrating target engagement and supporting the modification of disease. AD is incurable due to its multifactorial and complex nature. Biomarkers aid in characterizing the baseline state, a therapy response or a disease process. This book is compiled in such a manner, that it will provide in-depth knowledge about the assessment and management of Alzheimer's disease. It presents researches and studies performed by experts across the globe.

Handbook on Alzheimer's disease from aetiology and neurochemistry to diagnostic and therapeutic approaches. Intended to provide an introduction to all aspects of the disease.

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

The past 15 years have witnessed a remarkable increase in our knowledge of the neurobiology of Alzheimer?s disease, and as new findings occur, the need for sharing and evaluating the information becomes even more important. An indispensable and detailed volume, this book is a nucleus of the latest information, covering all aspects of the neurobiology of Alzheimer?s disease, its treatment and psychosocial aspects. Over the past two years, since the publication of the last volume, major advances have been made towards understanding the aetiology and the pathogenesis of this disease. These include the discoveries of the genes whose mutations associate with Alzheimer?s disease in familial cases; the mechanisms of neuronal degeneration and identification of specific steps in the neurodegenerative process that provide targets for therapeutic intervention. This volume also presents advances in the generation of cellular and animal models of ß-amyloid and tau pathology, the two hallmark lesions of Alzheimer?s disease. The chapters in this book are at the cutting edge of Alzheimer?s disease research and will be of enormous value not only to Alzheimer?s disease researchers, but also to neurobiologists, clinicians and caregivers.

This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.