Basic Science Of Pet Imaging

This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)

Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)

This reference on the basics of PET and PET/CT imaging has been revised with concise chapters on PET fundamentals. The chapters include pertinent basic science plus equations along with sample problems and practice questions.

This book provides a contemporary reference to the science, technology and clinical applications of PET and PET/CT. The book is designed to be used by residents and fellows training in medical imaging specialties as well as imaging experts in private or academic practice who need to become familiar with this technology and its applications. It is also for use by those whose specialties carry over to PET and PET/CT, referring physicians such as oncologists, cardiologists, neurologists and surgeons. Developed as an offshoot/update of the "clinical practice" portion of the main book, edited by PE Valk et al, published in 2003 (Positron Emission Tomography: basic science and clinical practice), this offshoot covers the second half of the main book only, dealing with mainly the clinical research and practice. Most of the book comprises chapters updated from the "Clinical practice" portion of the main Valk book. It contains 6 brand new chapters and 22 completely revised and updated chapters from the main Valk book.

This book provides comprehensive and detailed information on the scientific bases of nuclear medicine, addressing a wide variety of topics and explaining the concepts that underlie many of the investigations and procedures performed in the field. The book is divided into six sections that cover the physics and chemistry of nuclear medicine besides associated quality assurance/quality control procedures; dosimetry and radiation biology; SPECT and PET imaging instrumentation plus CT imaging technology in hybrid modalities; data analysis including image processing, reconstruction, radiomics, image degrading correction techniques, along with image quantitation and kinetic modeling. Within these sections, particular attention is paid to recent developments and the advances in knowledge that have taken place since release of the first edition in 2011. Several entirely new chapters have been included and the remaining chapters, thoroughly updated. Innovations in the ever-expanding field of nuclear medicine are predominantly due to integration of the basic sciences with complex technological advances. This excellently illustrated book on the subject will be of interest to not only nuclear medicine physicists and physicians but also clinical scientists, radiologists, radiopharmacists, medical students and technologists.

The Third Edition of this classic text presents the basic concepts of PET imaging technology. Topics include basic physics of PET imaging; detectors, scanners and data collection; storage, display, and PACS; PET radionuclides and radiopharmaceuticals; reimbursement for PET procedures; and performance of PET studies. This revised edition is thoroughly updated and includes information on new PET scanning detectors and PET/MRI scanners; PET/MRI data acquisition; software packages; recently developed PET radiopharmaceuticals; and new procedures for PET studies. To maximize understanding, the book includes pertinent basic science principles, equations, sample problems and practice questions. Basics of PET Imaging, Third Edition, is an ideal resource for nuclear medicine physicians, residents and technologists.

PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging. *Contains thorough tutorial treatments, coupled with coverage of advanced topics *Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors *Include color artwork

A comprehensive guide to procedures and technologies, Nuclear Medicine and PET/CT: Technology and Techniques provides a single source for state-of-the-art information on all aspects of nuclear medicine. Coverage includes relevant anatomy and physiology and discusses each procedure in relation to the specific use of radiopharmaceuticals and the instruments required. Edited by experts in nuclear imaging and PET/CT, Paul E. Christian and Kristen M. Waterstram-Rich, this edition has a new chapter on MRI as it relates to nuclear medicine and includes practical, step-by-step instructions for procedures. PET/CT focus with hybrid PET/CT studies in several chapters provides cutting-edge information that is especially beneficial to working technologists. CT Physics and Instrumentation chapter introduces CT as it is applied to PET imaging for combined PET/CT studies. Authoritative, comprehensive resource conveys state-of-the-art information, eliminating the need to search for information in other sources. Foundation chapters cover basic math, statistics, physics, instrumentation, computers, lab science, radiochemistry, and pharmacology, allowing you to understand how and why procedures are performed. Accessible writing style and approach to basic science subjects simplifies topics, progressing from fundamentals to more complex concepts. More than 50 practice problems in the math and statistics chapter let you brush up on basic math skills, with answers provided in the back of the book. Key terms, chapter outlines, learning objectives, and suggested readings help you organize your study. A table of radionuclides used in nuclear medicine and PET is provided in the appendix for quick reference. A glossary provides definitions of key terms and important concepts. High-profile editors and contributors come from a variety of educational and clinical settings, providing a broad philosophic and geographic perspective. New MRI Physics, Instrumentation and Clinical Introduction chapter provides important background on MRI and its relationship with nuclear medicine. Procedures boxes in body systems chapters provide step-by-step descriptions of clinical procedures. Updates and revisions keep you current with the latest advances. Expanded 16-page color insert includes more diagnostic images demonstrating realistic scans found in practice.

Praise for this book:Sure to be a hit -- just like the first edition...All the chapters are well written and the accuracy of information is impressive...[we] cannot recommend the book strongly enough.--RAD MagazineReturning in a second edition, this practical book presents oncological and nononcological applications for PET and PET/CT for the full range of scenarios frequently encountered in the professional setting. Placing special emphasis on PET/CT correlation and FDG oncological imaging, it opens with a thorough introduction to fundamental science and clinical basics. Each chapter in the Oncological Applications section of the book describes the role of PET and PET/CT in the management of specific diseases, providing succinct descriptions of indications and comparisons with other imaging modalities. Highlights: New chapters covering PET/CT for pediatric patients; the use of FDG PET in the evaluation of infection and inflammation; and the role of PET and PET/CT in radiation therapy planning; and FDG biology More than 500 high-quality images, including state-of-the-art color PET/CT images Pearls and pitfalls that emphasize critical concepts Discussion of normal variations and benign findings Thorough review of the current literature on PET/CT This compact book provides readers with the tools to sharpen their assessment and decision-making skills. Organized efficiently to enable rapid reference to key concepts, this concise text is ideal for residents and practitioners in radiology, nuclear medicine, oncology, radiation oncology, and nuclear medicine technology.