Avermectins

The future of insect control looked very bright in the 1950s and 1960s with new insecticides constantly coming onto the market. Today, however, whole classes of pesticide chemistry have fallen by the wayside due to misuse which generated resistance problems reaching crisis proportions, severe adverse effects on the environment, and public outcry that has led to increasingly stricter regulation and legislation. It is with this background, demanding the need for safer, environmentally friendly pesticides and new strategies to reduce resistance problems, that this book was written. The authors of the various chapters have a wealth of experience in pesticide chemistry, biochemical modes of action, mechanism of resistance and application, and have presented concise reviews. Each is actively involved in thedevelopment of new groups of pesticide chemistry which led to the development of novel insecticides with special impact in controlling agricultural pests. Emphasis has been given to insecticides with selective properties, such as insect growth regulators hormone mimics, ecdysone agonists), (chitin synthesis inhibitors, juvenile chloronicotinyl insecticides (imidacloprid, acetamiprid), botanical insecticides (neem, plant oils), pymetrozine, diafenthiuron, pyrrole insecticides, and others. The importance of these compounds, as components in integrated pest management programs and in insecticide resistance management strategies, is discussed. The data presented are essential in establishing new technologies and developing novel groups of compounds which will have impact on our future agricultural practices.

Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated 3e carries on the book’s tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions All major classes of pesticide considered Different routes of exposure critically evaluated

This volume, with contributions from leading international experts, reports on the need to produce high quality food whilst satisfying environmental concerns. Including material on natural products, modes of action and metabolism, it covers all the key areas in pesticide chemistry and related activities. The contents outline the developments that have taken place in approaches to crop protection and our ability to develop complex, environmentally acceptable strategies for weed, pest and disease control.

The revised Third Edition of The Prokaryotes, acclaimed as a classic reference in the field, offers new and updated articles by experts from around the world on taxa of relevance to medicine, ecology and industry. Entries combine phylogenetic and systematic data with insights into genetics, physiology and application. Existing entries have been revised to incorporate rapid progress and technological innovation. The new edition improves on the lucid presentation, logical layout and abundance of illustrations that readers rely on, adding color illustration throughout. Expanded to seven volumes in its print form, the new edition adds a new, searchable online version.

The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.

A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.

This book discusses various aspects of bioactive natural products employed in the agrochemical and agriculture sectors. It covers the use of plants, microorganisms, and microbial metabolites as eco-friendly, cost-effective, and sustainable alternatives to chemicals in the field of agriculture. Written by active researchers and academics, the book highlights state-of-art products in the field, as well as the gaps, challenges, and obstacles associated with the use of plants, microbes and their products. Given its scope, it is a valuable resource for the scientific community and professionals in enterprises wanting insights into the latest developments and advances in the context of biological products, including their applications, traditional uses, modern practices, and strategies to harness their full potential.