Applied Categorical Data Analysis And Translational Research

An updated treatment of categorical data analysis in the biomedical sciences that now explores applications to translational research Thoroughly updated with the latest advances in the field, Applied Categorical Data Analysis and Translational Research, Second Edition maintains the accessible style of its predecessor while also exploring the importance of translational research as it relates to basic scientific findings within clinical practice. With its easy-to-follow style, updated coverage of major methodologies, and broadened scope of coverage, this new edition provides an accessible guide to statistical methods involving categorical data and the steps to their application in problem solving in the biomedical sciences. Delving even further into the applied direction, this update offers many real-world examples from biomedicine, epidemiology, and public health along with detailed case studies taken straight from modern research in these fields. Additional features of the Second Edition include: A new chapter on the relationship between translational research and categorical data, focusing on design study, bioassay, and Phase I and Phase II clinical trials A new chapter on categorical data and diagnostic medicine, with coverage of the diagnostic process, prevalence surveys, the ROC function and ROC curve, and important statistical considerations A revised chapter on logistic regression models featuring an updated treatment of simple and multiple regression analysis An added section on quantal bioassays Each chapter features updated and new exercise sets along with numerous graphs that demonstrate the highly visual nature of the topic. A related Web site features the book's examples as well as additional data sets that can be worked with using SAS® software. The only book of its kind to provide balanced coverage of methods for both categorical data and translational research, Applied Categorical Data Analysis and Translational Research, Second Edition is an excellent book for courses on applied statistics and biostatistics at the upper-undergraduate and graduate levels. It is also a valuable reference for researchers and practitioners in the biomedical and public health fields.

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The nonstatistician's quick reference to applied categorical data analysis With a succinct, unified approach to applied categorical data analysis and an emphasis on applications, this book is immensely useful to researchers and students in the biomedical disciplines and to anyone concerned with statistical analysis. This self-contained volume provides up-to-date coverage of all major methodologies in this area of applied statistics and acquaints the reader with statistical thinking as expressed through a variety of modern-day topics and techniques. Applied Categorical Data Analysis introduces a number of new research areas, including the Mantel-Haenszel method, Kappa statistics, ordinal risks, odds ratio estimates, goodness-of-fit, and various regression models for categorical data. Chap T. Le, author of Health and Numbers and Applied Survival Analysis, presents his information in a user-friendly format and an accessible style while purposefully keeping the mathematics to a level appropriate for students in applied fields. Well supplemented with helpful graphs and tables, Applied Categorical Data Analysis: * Covers both basic and advanced topics * Employs many real-life examples from biomedicine, epidemiology, and public health * Presents case studies in meticulous detail * Provides end-of-chapter exercise sets and solutions * Incorporates samples of computer programs (most notably in SAS). Applied Categorical Data Analysis is an important resource for graduate students and professionals who need a compact reference and guide to both the fundamentals and applications of the major methods in the field.

Developed from the authors’ graduate-level biostatistics course, Applied Categorical and Count Data Analysis, Second Edition explains how to perform the statistical analysis of discrete data, including categorical and count outcomes. The authors have been teaching categorical data analysis courses at the University of Rochester and Tulane University for more than a decade. This book embodies their decade-long experience and insight in teaching and applying statistical models for categorical and count data. The authors describe the basic ideas underlying each concept, model, and approach to give readers a good grasp of the fundamentals of the methodology without relying on rigorous mathematical arguments. The second edition covers classic concepts and popular topics, such as contingency tables, logistic regression models, and Poisson regression models, along with modern areas that include models for zero-modified count outcomes, parametric and semiparametric longitudinal data analysis, reliability analysis, and methods for dealing with missing values. As in the first edition, R, SAS, SPSS, and Stata programming codes are provided for all the examples, enabling readers to immediately experiment with the data in the examples and even adapt or extend the codes to fit data from their own studies. Designed for a one-semester course for graduate and senior undergraduate students in biostatistics, this self-contained text is also suitable as a self-learning guide for biomedical and psychosocial researchers. It will help readers analyze data with discrete variables in a wide range of biomedical and psychosocial research fields. Features: Describes the basic ideas underlying each concept and model Includes R, SAS, SPSS and Stata programming codes for all the examples Features significantly expanded Chapters 4, 5, and 8 (Chapters 4-6, and 9 in the second edition Expands discussion for subtle issues in longitudinal and clustered data analysis such as time varying covariates and comparison of generalized linear mixed-effect models with GEE

A valuable new edition of a standard reference The use of statistical methods for categorical data has increased dramatically, particularly for applications in the biomedical and social sciences. An Introduction to Categorical Data Analysis, Third Edition summarizes these methods and shows readers how to use them using software. Readers will find a unified generalized linear models approach that connects logistic regression and loglinear models for discrete data with normal regression for continuous data. Adding to the value in the new edition is: • Illustrations of the use of R software to perform all the analyses in the book • A new chapter on alternative methods for categorical data, including smoothing and regularization methods (such as the lasso), classification methods such as linear discriminant analysis and classification trees, and cluster analysis • New sections in many chapters introducing the Bayesian approach for the methods of that chapter • More than 70 analyses of data sets to illustrate application of the methods, and about 200 exercises, many containing other data sets • An appendix showing how to use SAS, Stata, and SPSS, and an appendix with short solutions to most odd-numbered exercises Written in an applied, nontechnical style, this book illustrates the methods using a wide variety of real data, including medical clinical trials, environmental questions, drug use by teenagers, horseshoe crab mating, basketball shooting, correlates of happiness, and much more. An Introduction to Categorical Data Analysis, Third Edition is an invaluable tool for statisticians and biostatisticians as well as methodologists in the social and behavioral sciences, medicine and public health, marketing, education, and the biological and agricultural sciences.

Introduces the key concepts in the analysis of categoricaldata with illustrative examples and accompanying R code This book is aimed at all those who wish to discover how to analyze categorical data without getting immersed in complicated mathematics and without needing to wade through a large amount of prose. It is aimed at researchers with their own data ready to be analyzed and at students who would like an approachable alternative view of the subject. Each new topic in categorical data analysis is illustrated with an example that readers can apply to their own sets of data. In many cases, R code is given and excerpts from the resulting output are presented. In the context of log-linear models for cross-tabulations, two specialties of the house have been included: the use of cobweb diagrams to get visual information concerning significant interactions, and a procedure for detecting outlier category combinations. The R code used for these is available and may be freely adapted. In addition, this book: Uses an example to illustrate each new topic in categorical data Provides a clear explanation of an important subject Is understandable to most readers with minimal statistical and mathematical backgrounds Contains examples that are accompanied by R code and resulting output Includes starred sections that provide more background details for interested readers Categorical Data Analysis by Example is a reference for students in statistics and researchers in other disciplines, especially the social sciences, who use categorical data. This book is also a reference for practitioners in market research, medicine, and other fields.

This book offers a relatively self-contained presentation of the fundamental results in categorical data analysis, which plays a central role among the statistical techniques applied in the social, political and behavioral sciences, as well as in marketing and medical and biological research. The methods applied are mainly aimed at understanding the structure of associations among variables and the effects of other variables on these interactions. A great advantage of studying categorical data analysis is that many concepts in statistics become transparent when discussed in a categorical data context, and, in many places, the book takes this opportunity to comment on general principles and methods in statistics, addressing not only the “how” but also the “why.” Assuming minimal background in calculus, linear algebra, probability theory and statistics, the book is designed to be used in upper-undergraduate and graduate-level courses in the field and in more general statistical methodology courses, as well as a self-study resource for researchers and professionals. The book covers such key issues as: higher order interactions among categorical variables; the use of the delta-method to correctly determine asymptotic standard errors for complex quantities reported in surveys; the fundamentals of the main theories of causal analysis based on observational data; the usefulness of the odds ratio as a measure of association; and a detailed discussion of log-linear models, including graphical models. The book contains over 200 problems, many of which may also be used as starting points for undergraduate research projects. The material can be used by students toward a variety of goals, depending on the degree of theory or application desired.

Praise for the Second Edition "A must-have book for anyone expecting to do research and/or applications in categorical data analysis." —Statistics in Medicine "It is a total delight reading this book." —Pharmaceutical Research "If you do any analysis of categorical data, this is an essential desktop reference." —Technometrics The use of statistical methods for analyzing categorical data has increased dramatically, particularly in the biomedical, social sciences, and financial industries. Responding to new developments, this book offers a comprehensive treatment of the most important methods for categorical data analysis. Categorical Data Analysis, Third Edition summarizes the latest methods for univariate and correlated multivariate categorical responses. Readers will find a unified generalized linear models approach that connects logistic regression and Poisson and negative binomial loglinear models for discrete data with normal regression for continuous data. This edition also features: An emphasis on logistic and probit regression methods for binary, ordinal, and nominal responses for independent observations and for clustered data with marginal models and random effects models Two new chapters on alternative methods for binary response data, including smoothing and regularization methods, classification methods such as linear discriminant analysis and classification trees, and cluster analysis New sections introducing the Bayesian approach for methods in that chapter More than 100 analyses of data sets and over 600 exercises Notes at the end of each chapter that provide references to recent research and topics not covered in the text, linked to a bibliography of more than 1,200 sources A supplementary website showing how to use R and SAS; for all examples in the text, with information also about SPSS and Stata and with exercise solutions Categorical Data Analysis, Third Edition is an invaluable tool for statisticians and methodologists, such as biostatisticians and researchers in the social and behavioral sciences, medicine and public health, marketing, education, finance, biological and agricultural sciences, and industrial quality control.

Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Fourth Edition focuses on the statistical aspects ofmedicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. This edition includes more topics in order to fill gaps in the previous edition. Various topics have been enlarged and modified as per the new understanding of the subject.

Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Third Edition focuses on the statistical aspects of medicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. The author concludes "Just as results of medical tests, statistical results can be false negative or false positive". This edition provides expanded coverage of topics and includes software illustrations. The author presents step-by-step explanations of statistical methods with the help of numerous real-world examples. Guide charts at the beginning of the book enable quick access to the relevant statistical procedure, and the comprehensive index makes it easier to locate terms of interest.