Adrenal And Endocrine Tumors In Children

, Adrenal and Endocrine Tumors in Children' is the third volume in the series, 'Cancer Treatment and Research' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D' Angio and for che motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Child ren's Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

This book provides in-depth practical advice on how to manage children with endocrine conditions that may benefit from surgery. It is more detailed than general pediatric surgery texts and more surgically oriented than endocrinology texts. The first section is devoted to the thyroid and parathyroid, with detailed discussion of thyroid nodules, thyroid cancer, hyperthyroidism, hyperparathyroidism, and multiple endocrine neoplasia. The second section on the pancreas focuses on nesidioblastosis, islet cell transplantation, the surgical treatment of diabetes, and surgical complications of diabetes. Adrenal disorders are then discussed, followed by a section on the evaluation and management of ovarian and testicular torsion and tumors. The closing section addresses miscellaneous topics such as gynecomastia in boys and growth restriction surgery. This book will serve as an invaluable reference for all practitioners and trainees who care for children with endocrine problems for which surgery is considered.

This book is designed to present a comprehensive and state-of the-art approach to the management of adrenal neoplasms that provides a resource to the broad group of providers that will encounter such a patient. Sections address issues that are faced by providers who encounter a patient with an adrenal neoplasm. These areas include an overview of the genetic basis and familial cancer syndrome-associated with adrenal neoplasms, pathobiology, advanced and tumor specific imaging approaches and technologies, biochemical analysis, standard medical and surgical therapies, and emerging technology and treatment approaches to benign and malignant adrenal neoplasms. Written by experts in the field, each of these sections address level of clinical evidence and provide recommendations and treatment algorithms. Extensive illustrations make this an interactive text. Management of Adrenal Masses in Children and Adults will serve as a very useful resource for all providers dealing with, and interested in this common but challenging tumor. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

Andrew Arnold The past several years have been a time of intense excitement and have brought major advances in the understanding and treatment of endocrine neoplasms. This is therefore an excellent point at which to undertake a broad based overview of the state of the art in endocrine neoplasia for the Cancer Treatment and Research series. Because of the wide and interdisciplinary readership of this series, our aim for each chapter has been to provide ample background for those not highly familiar with the topic, while emphasizing the most recent advances. Furthermore, the chapters have been written with the clinician in mind, whether she or he is an oncologist, endocrinologist, surgeon, generalist, pathologist, or radiologist. As such, the authors' mission has been to focus on clinically relevant issues and to present the scientific basis of current or potential future advances in a manner easily digestible to the nonexpert. Endocrine tumors often cause problems for the patient by virtue of their hormonal activity, which may frequently (but certainly not always) over shadow the adverse consequences related to their mass per se. In fact, it is important to keep in mind that endocrine tumors can manifest two biologically separable but often intertwined properties, namely, increased cell mass and abnormal hormonal function. These need not go hand in hand, and their distinction has definite clinical relevance in, for example, the increasingly recognized problem of incidentally discovered adrenal or pituitary masses.

Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals Focuses on the impact upon costs and patient deaths due to complications of these tumors Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors Provides review questions with an answer key and detailed glossary

Adrenal Cortical Carcinoma is classically associated with a dismal prognosis. Yet its clinical presentation is changing (more and more classified as “incidentaloma”). New insights have emerged on its pathophysiological mechanisms (through the genetic elucidation of familial syndromes), and Reference Centers within National and European Networks are now offering more standardized and efficient multidisciplinary clinical management of these difficult patients. All these important aspects are described by experts in nine chapters dealing with epidemiology, prognosis, and clinical management, pathology, molecular pathophysiological mechanisms, modern imaging approaches, surgical and chemotherapeutical approaches of primary and secondary lesions, and the particular aspects of adrenal cortical carcinoma in children. This book, with its many figures and photographs, will be of major interest to endocrinologists, radiologists and nuclear medicine experts, pathologists, surgeons, oncologists, pediatricians. After a thorough reading, one will better recognize a suspicious adrenal “incidentaloma”, diagnose steroid hypersecretion, suspect a familial disease, consult with the pathologist and surgeon, manipulate difficult drugs like O,p'DDD, participate in multidisciplinary discussions with oncologists, radiotherapeutists, molecular biologists… Modern medicine in action!

Cancer is diagnosed in about 140 per million children in Britain each year. There is a 1 in 500 chance that a child will be affected in the first 15 years of life, the most frequently occurring types of cancer being leukaemia and brain tumours. This book covers the descriptive epidemiology of childhood cancer in Britain, based on the unique work of the National Registry of Childhood Tumours, the largest population-based specialist childhood cancer registry in the world. The book provides a detailed account of national incidence and survival rates for childhood cancer in Britain during 1991-2000, and trends during 1966-2000. There is also an account of childhood mortality for the period 1965-2004. The diagnoses are classified throughout according to the International Classification of Childhood Cancer, the first time the third edition of this standard classification has been used for prevalence of incidence, survival and mortality data. The chapter on incidence rates is relevant to planning of health service provision and design of research studies on aetiology, whilst the chapter on trends in incidence is relevant to the possible effects of changes in environmental and other risk factors. In addition to comprehensive tables of rates, age-incidence graphs are provided for all the major types of childhood cancer, and possible artefacts are also discussed. The survival data demonstrates how clinical progress over the past 40 years has led to a major increase in the number of cancer survivors. The role of the Registry, covering history, methodology, current and future uses, is also discussed. This definitive work is the culmination of decades of epidemiological research and is essential reading for anyone involved in paediatric oncology or cancer epidemiology.